When the best decision is no decision: the rise of randomization in grant funding

If reviewers can’t reliably tell the difference between top grant proposals, why should they pretend they can? A new wave of funders is turning to lotteries to break the tie.

nature.com

LDL Cholesterol Targeting in Cardiovascular Disease | NEJM

To the Editor: In the Ez-PAVE trial conducted in South Korea, Lee and colleagues (April 9 issue)1 report that intensive lowering of the low-density lipoprotein (LDL) cholesterol level to a target o...

nejm.org

Could this mysterious disappearing organ hold the key to longevity?

Researchers are racing to regrow the thymus, an ephemeral immune organ, in the hope that it will slow ageing.

nature.com

The F.D.A. Approves a New Pill to Slash Cholesterol Levels

The new pills can lower cholesterol levels far below what can be achieved with statins, clinical trials have shown.

nyti.ms

A Proposed Rule Would Politicize Medical Research. Scientists Are Not Happy.

nytimes.com

Combined anti-CD20/anti-CD38 therapy in recurrent FSGS: Results Before Reasons

Recurrent focal segmental glomerulosclerosis (rFSGS) remains one of the most feared complications after kidney transplantation. Recurrence occurs in approximately one-third of patients with primary FS...

kireports.org

Frontiers | Echocardiography-guided assessment of mouse cardiac transplant rejection improves model reproducibility

BackgroundThe mouse heterotopic heart transplant model is a widely used system for dissecting mechanisms of graft rejection and identifying new therapeutic t...

frontiersin.org

Frontiers Publishing Partnerships | Not all antibodies are created equal: total IgG glycosylation and severity of antibody-mediated rejection in kidney transplantation

Antibody-mediated rejection (AMR) is a leading cause of kidney transplant failure and is primarily driven by donor-specific anti-HLA antibodies (DSA), althou...

frontierspartnerships.org

Circulating IgM does not target common chemical adducts in recurrent FSGS

Recurrent primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation remains a major cause of early graft dysfunction and loss.1 Increasing evidence implicates natural IgM antibodi...

kireports.org

Circulating IgM does not target common chemical adducts in recurrent FSGS

Recurrent primary focal segmental glomerulosclerosis (FSGS) after kidney transplantation remains a major cause of early graft dysfunction and loss.1 Increasing evidence implicates natural IgM antibodi...

kireports.org

Dual anti-CD20/anti-CD38 therapy for severe recurrent FSGS with longitudinal anti-nephrin assessment

To the Editor,

academic.oup.com

journals.lww.com

I felt confined by my disciplinary training. Making art freed my scientific ideas

“I am now forging a more creative path,” this professor writes

science.org

Urinary Single-Cell Transcriptomics in Kidney Transplantation: Elucidation of Donor–Recipient Cellular Dynamics and Fibrogenic Stress

Urinary single-cell RNA sequencing (scRNA-seq) provides a noninvasive and mechanistically informative approach for studying kidney allograft biology. We established a high-quality urinary scRNA-seq wo...

amjtransplant.org

Beyond traditional roles: vitamin D and erythropoietin as immune modulators in kidney diseases

ABSTRACT. Vitamin D and erythropoietin (EPO) are kidney-derived hormones classically known for their roles in mineral metabolism and erythropoiesis, respec

academic.oup.com

The Impact of Initial Kidney Graft Function on Long-term... : Transplantation

An abstract is unavailable.

journals.lww.com

CDER proposes to withdraw approval of TAVNEOS

CDER proposes to withdraw approval of TAVNEOS

fda.gov

CKD remission and even regression: a vision reaffirmed

sciencedirect.com

Mechanisms and Treatment of Immune Complex GN and C3 GN

YouTube video by American Society of Transplantation

youtube.com

B-cell-targeting therapies in podocytopathies - Pediatric Nephrology

Podocytopathies, including minimal change disease and focal segmental glomerulosclerosis, represent the leading causes of nephrotic syndrome in children and adolescents. Although traditionally conside...

link.springer.com

‘Science needs defending’: record number of researchers run for office in US mid-terms

Many Democrats making the switch to politics are motivated by the Trump administration’s cuts to science — whereas energy and AI are a pull for some Republicans.

nature.com

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Dual Anti-CD20/Anti-CD38 Therapy for Severe Recurrent FSGS with Longitudinal Anti-Nephrin Assessment

Xhuliana Kajana, Agnese Spennacchio, Francesca Chiara Viazzi, Carolina Bigatti, Pasquale Esposito, Angelica Parodi, Gianluca Caridi, Daniela Picciotto, Mar

academic.oup.com

Autosomal dominant polycystic kidney disease

Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic cause of chronic kidney disease, resulting in substantial morbidity and mortality globally. Advances in molecular geneti...

thelancet.com

Iptacopan in IgA Nephropathy — Final 24-Month Data | NEJM

Overactivation of the alternative complement pathway contributes to IgA nephropathy and glomerular inflammation. In the 9-month interim analysis of this phase 3 trial, iptacopan, a complement facto...

nejm.org

Preclinical and clinical studies on kidney allograft tolerance via hematopoietic chimerism

In current clinical practice, successful kidney transplantation requires lifelong immunosuppression to prevent graft rejection, which is unfortunately associated with significant morbidity, mortality,...

amjtransplant.org