The therapeutic approach to cardiovascular–kidney–metabolic syndrome - Nature - goo.gl/alerts/wJh5c5 #GoogleAlerts
The therapeutic approach to cardiovascular–kidney–metabolic syndrome - Nature Reviews Nephrology
Here the authors discuss the therapeutic approach to cardiovascular–kidney–metabolic syndrome, including screening across the lifespan, lifestyle interventions and guideline-directed medical therapies...
goo.gl
Agree TTE is the new fashion (like regression and propensity score matching before) And the black box of methods makes review and critical appraisal very difficult
Isn’t this just a set up for selection bias by indication? How do you retrospectively “target trial” emulate a contrast CT? Patients who got contrast post AKI could have unmeasurable illness. Patients who didn’t get it were obviously doing ok. @kidneyboy.bsky.social @hswapnil.medsky.social
American Journal of Kidney Diseases@ajkd.bsky.social · 21h agoKidney Outcomes After Contrast Exposure in Patients Recovering From Dialysis-Requiring Acute Kidney Injury: A Target Trial Emulation Study bit.ly/4wsFue2
Urinary #CXCL9 Across the Spectrum of #Kidney #Allograft #Inflammation #VisualAbstract by Husam Alzayer https://www.kireports.org/article/S2468-0249(26)02934-7/fulltext
Randomized Controlled Trial of Corticosteroid Tapering in Steroid-Sensitive Podocytopathy #nephsky #nephrology www.kireports.org/article/S246...
Randomized Controlled Trial of Corticosteroid Tapering in Steroid-Sensitive Podocytopathy
Corticosteroids remain the cornerstone of therapy for podocytopathies, including minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS), in both adults and children. However, the o...
kireports.org
Kidney failure risk equation and early renal risk in adults with sickle cell disease: comparison with KDIGO classification using measured GFR #nephsky #nephrology www.tandfonline.com/doi/full/10....
Kidney failure risk equation and early renal risk in adults with sickle cell disease: comparison with KDIGO classification using measured GFR
Chronic kidney disease is a major complication of sickle cell disease (SCD), but early kidney injury frequently occurs despite preserved or increased glomerular filtration rate (GFR), potentially l...
tandfonline.com
IL-33 as a component of neutrophil extracellular traps mediates contrast-induced acute kidney injury by promoting ferroptosis in tubular epithelial cells doi.org/10.1016/j.kint.2026.06.039 #NephSky #MedSky
HBV-associated cryoglobulinemic glomerulonephritis misdiagnosed as lupus nephritis: the value of clinicopathologic integration - Kidney International Reports www.kireports.org/article/S246...
HBV-associated cryoglobulinemic glomerulonephritis misdiagnosed as lupus nephritis: the value of clinicopathologic integration
Hepatitis B virus (HBV)–associated cryoglobulinemic glomerulonephritis (CryoGN) is an uncommon immune complex–mediated kidney disease that frequently presents with a membranoproliferative glomerulonep...
kireports.org
GLP-1 medicines act beyond weight loss, engaging neural, immune, vascular and organ-specific pathways that improve glucose control, inflammation, blood pressure, heart, liver, kidney and mobility. www.cell.com/cell-metabol...
Weight-loss-independent actions of GLP-1 medicines
The unprecedented broad efficacy of GLP-1 medicines reflects mechanisms beyond weight loss. GLP-1R agonism recruits neural and immune circuits, inter-organ communication, and engages local GLP-1Rs to ...
cell.com
Does HCO₃ really not work in #AKI, or are we comparing different strategies? @nephjc.bsky.social A hypertonic HCO₃ bolus differs physiologically from continuous HCO₃-based balanced crystalloids. How HCO₃ is given may matter as much as whether it is used. www.cureus.com/articles/168...
Bicarbonate-Based Solution for the Management of Established Acute Kidney Injury: A Pilot Open-Label Observation Study
Background Administration of intravenous (IV) solutions constitutes a key component of acute kidney injury (AKI) management. However, the optimal IV fluid solution in the setting of AKI remains uncer...
cureus.com
Clinicopathological features and outcomes of glomerular microangiopathy: a retrospective cohort study #nephsky #nephrology www.tandfonline.com/doi/full/10....
Clinicopathological features and outcomes of glomerular microangiopathy: a retrospective cohort study
Glomerular microangiopathy (GMA) is a group of diseases characterized pathologically by thrombotic microangiopathy (TMA) changes in the glomerulus without detectable microthrombi or intima edema of...
tandfonline.com
Neutrophils in Kidney Disease: Linking Neutrophil Function and Microenvironment to Therapeutic Targets
Neutrophils in Kidney Disease: Linking Neutrophil Function and Microenvironment to Therapeutic Targets - PubMed
Neutrophils are central mediators of kidney immunity and injury, exerting both protective and pathogenic functions on tissue compartment, inflammatory response, and disease state. During urinary tract...
pubmed.ncbi.nlm.nih.gov
🏥While SGLT2 inhibitors are known to benefit kidney health in type 2 diabetes, evidence in type 1 diabetes remains limited. This study investigates the renal outcomes associated with ipragliflozin use in T1D. 📎 mdpi.com/2227-9059/13... #Diabetes #SGLT2 #T1D #Kidney
Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic–ischemic encephalopathy @ped-neph.bsky.social #nephsky link.springer.com/article/10.1...
Comparison of KDIGO and nRIFLE criteria for acute kidney injury in neonates with hypoxic–ischemic encephalopathy - Pediatric Nephrology
Background Acute kidney injury (AKI) is a common complication in neonates with hypoxic–ischemic encephalopathy (HIE), however, its diagnosis remains challenging due to the unique physiology of the neo...
link.springer.com
Natural History and Post-transplant Outcomes Among Patients with Kidney #LECT2 #amyloidosis. This is our internal data about kidney function before diagnosis and after transplant in those #ALECT2 #orphandisease #kidneydisease www.medrxiv.org/content/10.6...
Natural History and Post-transplant Outcomes Among Patients with Kidney Leukocyte Cell- Derived
Background: ALECT2 is the third most common cause of renal amyloidosis in the United States, with a strong predilection for Hispanic patients in the Southwest. (PMID:24522497) Despite its regional…
medrxiv.org
VISIONARY: Sibeprenlimab in IgA nephropathy #IgAN ✅ Proteinuria reduction ✅ Preservation of kidney function #Nephpearls #GlomConHawaii 🌊 #NephSky #VisualAbstract by @alexgr23.bsky.social
#HotOffThePress academic.oup.com/ajh/advance-... #OpenAccess Increased Excitability of Renal Sensory Neurons by Vasopressin in Male and Female Sprague Dawley Rats
Value of pronase IF in renal path. MN pattern with dominant C3 staining becomes membranous like glomerulopathy with IgG kappa deposits on pronase IF. SAP + confirms diagnosis. #renalpath #nephsky #pathsky
ZEUS thunderbolt does not land uk.finance.yahoo.com/news/novo-no... Need to see full data at #KidneyWk - treating just inflammation likely doesn’t make sense
Novo Nordisk provides update on the ZEUS phase 3 trial in people with ASCVD, CKD and inflammation
Bagsværd, Denmark, 31 July 2026 – Novo Nordisk today announced headline results from the ZEUS cardiovascular outcomes phase 3 trial. While ziltivekimab demonstrated target engagement and inhibition of...
uk.finance.yahoo.com
I was a site PI for the Zeus #ziltivekimab RCT and I am glad to see the top line summary so soon after database lock. After Zeus we should ? the inflammation - CVD link in a fundamental manner: perhaps it is the proximal cause of inflammation, rather than inflammation per se the driver of CVD
PTH signaling through the ciliary receptor Pth1r promotes cyst growth in ADPKD. Pth1r is upregulated early in disease, and its deletion or PTH lowering with cinacalcet reduces cyst burden, highlighting the PTH-Pth1r-cilia pathway as a potential therapeutic target. kidney.pub/JASN1170?... #ASNJASN
Mediators of cell fate decisions in human fetal kidney development identified using spatial transcriptomics @natgenet.nature.com @ksusztak.bsky.social @pennmedicine.bsky.social www.nature.com/articles/s41... www.nature.com/articles/s41...
Uromodulin T62P variant causes kidney tubular stress and injury modulated by age and polygenic risk https://www.medrxiv.org/content/10.64898/2026.07.29.26359269v1
Fibrin extravasating into Bowman's capsule in this case of MPO-ANCA associated pauci immune GN. Destructive necrotizing cellular crescent. Prominent necrotizing arteritis as well. #renalpath #pathsky #nephsky
Another interesting case with crescents but this time due to amyloid. A few small cellular crescents in this case of AL-amyloidosis. Massive capillary wall amyloid infiltration. #renalpath #pathsky #nephsky
Guidance on nutrition supplementation in dialysis www.kireports.org/article/S246... In @kireports.bsky.social Increasing protein intake once dialysis begins is important!
NHS seeks more south Asian organ donors as waiting list grows #NHS #OrganDonation #SaveLives #SouthAsian #Healthcare #Transplant #KidneyHealth #DonateLife #HealthAwareness #PatientCare www.easterneye.biz/nhs-seeks-mo...
NHS Warns of Organ Donor Gap as South Asian Patients Face Longer Waits
More than 550 people are waiting for a transplant, while only 26 deceased South Asian donors were recorded in the past year
easterneye.biz
A patient with zero calculated chance of finding a compatible donor kidney received a successful transplant after 31 weeks of teclistamab. The antibody reduction reached levels not possible with current methods. doi.org/hcc5qp
Cancer drug enables kidney transplant despite severe immune incompatibility
An international research team led by the Medical University of Vienna reports on a new treatment strategy that has made kidney transplantation possible for a patient with no realistic chance of receiving a suitable donor organ.
medicalxpress.com
In #T2D on insulin and #hemodialysis, %TBR was low & not affected by #rtCGM. Compared to capillary glucose testing, %TIR, mean glucose and %TAR improved during the #rtCGM intervention. Read here ➡️ doi.org/10.2337/dc26-0404
