CRC 1430
@crc1430.bsky.social
DFG funded Collaborative Research Centre 1430 "Molecular Mechanisms of Cell State Transitions" @unidue.bsky.social @unidue-zmb.bsky.social
Over the past few weeks, several members of the #ZMB community and @crc1430.bsky.social have successfully defended their doctoral theses. Congratulations!🎓 We wish you every success in the next stage of your scientific careers and hope to stay in touch!
🧬 🔬 How do cells coordinate the forces required for successful division? A new preprint from the Nalbant lab and @icce-unidue.bsky.social colleagues provides insights by identifying a key role for Ect2 in regulating cortical contractility during cytokinesis. www.biorxiv.org/content/10.6...
Constitutive plasma membrane interaction of active Rho GEF Ect2 inhibits cortex contraction pulses
During cell division, multiple guanine nucleotide exchange factors (GEFs), including the mitotic regulator Ect2 and Lbc-type GEFs, regulate the dynamics of RhoA activity and actomyosin contractility. ...
biorxiv.org
Great PhD Retreat at Unperfekthaus Essen! Connected across projects, presented science in talks & Chalk Talks and discussed career paths in a panel with both industry & academia backgrounds. Thanks for inspiring discussions, exchange and new connections! 🧪 #CRC1430 #Networking @leokiss.bsky.social
What a great evening at this years' company run in Essen! 🏃♀️🏃♂️🎉 Several CRC 1430 groups, including @hemmo-lab.bsky.social and @icce-unidue.bsky.social, joined the race. Great teamwork, great spirit, and lots of fun—both on and off the course! 💙 #CRC1430 #TeamScience @unidue-zmb.bsky.social
Congratulations to @vcmentowski.bsky.social on receiving the Otto Hahn Medal! We are delighted to celebrate this outstanding achievement by a former PhD student from @andrea-musacchio.bsky.social's lab within CRC 1430. Wishing you continued success in your scientific career!
Verena Cmentowski@vcmentowski.bsky.social · 2mo agoFeeling truly honored to receive the Otto Hahn Medal from the @maxplanck.de ! Huge thanks to my mentor @andrea-musacchio.bsky.social for his continuous guidance and support over the years. It has been a pleasure working with you.
New collaborative work from @crc1430.bsky.social now published in @natcomms.nature.com: Targeted degradation of #USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors. ➡️ www.nature.com/articles/s41...
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors - Nature Communications
DUBs regulate key cellular processes, but selective tools are scarce. Here, the authors developed PROTACs for the DUB USP7, comparing degraders with inhibitors. The study provides a valuable toolbox f...
nature.com
Next #ZMB and @crc1430.bsky.social seminar at @unidue.bsky.social around the corner! On May 19, we’re happy to welcome @joostholthuis.bsky.social, Osnabrück University, who will present on "Lipid dynamics and function in membrane repair". See you May 19, 4.15pm, S05V01E69, Campus Essen! #CellNanOs
Next up: Katerina Naydenova, Group Leader at the Max Planck Institute of Molecular Physiology, will present "Molecular mechanisms of #ubiquitin ligases with activity towards non-protein substrates". 📅 22 April 2026 ⏰ 12:30 📍 S05 V01 E69 ➡️ www.mpi-dortmund.mpg.de/forschungsgr...
Katerina Naydenova
Katerina Naydenova
mpi-dortmund.mpg.de
Looking forward to the talk of Jelger Risselada @tu-dortmund.de today ! Join us in the #ZMBLunchSeminar and learn about Molecular Dynamics and #MembraneProperties @unidue-zmb.bsky.social
Center of Medical Biotechnology@unidue-zmb.bsky.social · 4mo agoHappening today! Jelger Risselada @tu-dortmund.de speaks on "From Explanation to Prediction and Back: Theory and Evolutionary #MolecularDynamics of Membrane Property Sensing and Biocondensate Formation/Aging". 📅 15 April 2026 ⏰ 12:30 📍 S05 V01 E69
Looking forward to the talk of Jelger Risselada @tu-dortmund.de today ! Join us in the #ZMBLunchSeminar and learn about Molecular Dynamics and #MembraneProperties @unidue-zmb.bsky.social
Center of Medical Biotechnology@unidue-zmb.bsky.social · 4mo agoHappening today! Jelger Risselada @tu-dortmund.de speaks on "From Explanation to Prediction and Back: Theory and Evolutionary #MolecularDynamics of Membrane Property Sensing and Biocondensate Formation/Aging". 📅 15 April 2026 ⏰ 12:30 📍 S05 V01 E69
Congratulations @vcmentowski.bsky.social! Well-deserved award for an excellent PhD work performed in the @andrea-musacchio.bsky.social lab. @imprs-lm.bsky.social @crc1430.bsky.social
GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 4mo agoThe Bayer Pharmaceuticals #PhDAward of the #GBM is presented to Verena Cmentowski for her PhD thesis on the „Assembly principles of the kinetochore corona and their relevance for mitotic checkpoint signaling“. Congratulations, Verena! #MK2026
Big congrats to our SFB alumna @vcmentowski.bsky.social on receiving the Bayer Pharmaceuticals PhD Award! Her work (previously also conducted in @andrea-musacchio.bsky.social's lab) reveals how CENP-E orchestrates kinetochore corona assembly and links it to mitotic checkpoint signaling. 🎉
GBM (Gesellschaft für Biochemie und Molekularbiologie)@gbmev.bsky.social · 4mo agoThe Bayer Pharmaceuticals #PhDAward of the #GBM is presented to Verena Cmentowski for her PhD thesis on the „Assembly principles of the kinetochore corona and their relevance for mitotic checkpoint signaling“. Congratulations, Verena! #MK2026
Looking forward to the talk of Olaf Stemmann @unibayreuth.bsky.social as part of the #ZMBCRC1430 Guest Speaker Series! Join us and @unidue-zmb.bsky.social next Tuesday, 4.15 pm. 🧪
Center of Medical Biotechnology@unidue-zmb.bsky.social · 5mo agoNext up in the ZMB/@crc1430.bsky.social Speaker Series: Olaf Stemmann @unibayreuth.bsky.social on "The #p53 -dependent mitotic surveillance pathway: Insights into an anti-cancer cellular clock". 📅 24 March 2026 ⏰ 4.15 pm 📍 S05 V01 E69 #genetics #cellbiology #mitosis
Great opportunity to join @hellerschmiedlab.bsky.social @unidue.bsky.social @imprs-lm.bsky.social
IMPRS for Living Matter@imprs-lm.bsky.social · 5mo agoInterested in uncovering how the #Golgi reacts to stress? Apply NOW to the @hellerschmiedlab.bsky.social @imprs-lm.bsky.social #chembio #cellbio #biochemistry
Join us today for an exciting @crc1430.bsky.social seminar at @unidue.bsky.social! We’re happy to welcome Christian Ungermann, who will be presenting “Insights into endolysosomal membrane homeostasis.” 🔬✨ #Endosomes #Lysosomes #MembraneTrafficking #CellBiology #MembraneFusion
Our @crc1430.bsky.social PhDs organized a wonderful retrospection and farewell event for their fellow PhD candidates 🎓✨ Thank you for the engaging discussions and the positive atmosphere. A successful gathering to close this chapter together 🤝 #PhDLife #Networking #Science
CRC 1430@crc1430.bsky.social · 9mo agoExcited about today’s @crc1430.bsky.social @unidue.bsky.social talk by Roland Schwarz from the ICCB Cologne, hosted jointly with WTZ! He will present on: "Inferring clonal evolution in chromosomally unstable tumours." #ComputationalBiology #CancerGenomics #CancerEvolution
Excited about today’s @crc1430.bsky.social @unidue.bsky.social talk by Roland Schwarz from the ICCB Cologne, hosted jointly with WTZ! He will present on: "Inferring clonal evolution in chromosomally unstable tumours." #ComputationalBiology #CancerGenomics #CancerEvolution
Looking forward to tomorrow’s @crc1430.bsky.social seminar @unidue.bsky.social! We are excited to welcome Viktor Korolchuk @korolchuklab.bsky.social, who will present on: "Selective autophagy in ageing: mechanisms and functions" #Autophagy #CellBiology #Collaboration
Great news from our recent @crc1430.bsky.social Female Scientist Get-Together 🎉👩🔬☕ Participants shared experiences on balancing scientific careers and personal life - a topic many want to explore further in a future workshop 💪✨ #EquityInScience #CareerDevelopment
A new exciting paper by the @hemmo-lab.bsky.social in @embojournal.org highlights the role of ATXN3 in lysosome regeneration after damage. Especially proud of our @crc1430.bsky.social PhD student who is first author on this paper! 🎉✨
Center of Medical Biotechnology@unidue-zmb.bsky.social · last yr.New work out by @hemmo-lab.bsky.social @icce-unidue.bsky.social @kulathu.bsky.social and others on how ATXN3 restores lysosome integrity after damage by targeting K48- and K63-branched ubiquitin chains. Full story: www.embopress.org/doi/full/10.... @unidue.bsky.social @crc1430.bsky.social @dfg.de
@hellerschmiedlab.bsky.social and partners reveal 'Conformational plasticity of a BiP–GRP94 chaperone complex', a study made possible through funding by @crc1430.bsky.social @dfg.de Find out more: www.nature.com/articles/s41...
Conformational plasticity of a BiP–GRP94 chaperone complex - Nature Structural & Molecular Biology
BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mecha...
nature.com
Universität Duisburg-Essen@unidue.bsky.social · last yr.It’s crucial to our health how #proteins in the #cells attain their correct structure. Errors in this process can lead to serious diseases. @unidue-zmb.bsky.social, together with partners, have now deciphered a central mechanism of this essential cellular process. www.uni-due.de/2025-07-21-n...
We’re proud to see five @crc1430.bsky.social subprojects come together in this joint publication in @natsmb.nature.com! 💥 Huge congratulations to @hellerschmiedlab.bsky.social, @poepsel-lab.bsky.social, and the labs of Sánchez-García, Kaiser & Kaschani. 🔗 www.nature.com/articles/s41...
Conformational plasticity of a BiP–GRP94 chaperone complex - Nature Structural & Molecular Biology
BiP–glucose-regulated protein 94 chaperones are critical to the proper folding of secretory and transmembrane proteins. Brenner et al. provide biochemical and structural insight into a conserved mecha...
nature.com
Hellerschmied Lab@hellerschmiedlab.bsky.social · last yr.Very happy to see our contribution to a better understanding of Hsp70/90 #chaperones online! Congrats and a big thank you to all co-authors, collaborators and reviewers! #proteostasis @poepsel-lab.bsky.social @crc1430.bsky.social @unidue-zmb.bsky.social
Great news from yesterday’s @crc1430.bsky.social Female Scientists Get-Together 🎉👩🔬☕ We are now planning and preparing the negotiations workshop for women 💪✨ After the summer break ☀️, we’ll focus on publications 📚 to get ready for the workshop. #EquityInScience #CareerDevelopment
A fantastic example of what strong collaborations can achieve! Congrats 🎉 to our @crc1430.bsky.social members from @maltegersch.bsky.social, Grüner, Paschen, Knapp, Kaiser labs, and our core facilities ACE & @icce-unidue.bsky.social Especially proud of our PhD students for their excellent teamwork!
Niko Klink@nikolasklink.bsky.social · last yr.Really excited to share the first chapter of my PhD as a preprint titled: Targeted degradation of USP7 in solid cancer cells reveals disparate effects of deubiquitinase inhibition vs. acute protein depletion: www.biorxiv.org/content/10.1.... If that sounds interesting to you, small tweetorial below👇
🧭 What are my further career movements? PhDs & Postdocs of @crc1430.bsky.social explored this key question in a career planning workshop. Through interactive exercises, they gained clarity on their skills, values, and future paths - inside or outside academia. #PhDCareer #PostdocLife #CareerPlanning
Great exchange at today´s @crc1430.bsky.social Female Scientists Get-Together! 👩🔬☕ Strong interest in the “Negotiations for Women” workshop - a small but important step toward closing the gender pay gap 💪🎯 and strengthening career paths for women in science 🧠🚀 #EquityInScience #CareerDevelopment
Looking forward to tomorrow’s @crc1430.bsky.social seminar @unidue.bsky.social! We are excited to welcome Thorben Cordes @tu-dortmund.bsky.social, who will present on: "Novel optical spectroscopy methods for mechanistic biochemical and biophysical studies of active membrane transporters" #Biophysics
A successful @crc1430.bsky.social PhD Career Day is behind us! Thank you to all participants for the lively discussions and to our six guest speakers for their valuable insights. We enjoyed a day full of career advice, inspiring talks, and great networking over dinner. #PhDCareers #JobsAfterPhD
CRC 1430@crc1430.bsky.social · last yr.We’re excited for tomorrow’s @crc1430.bsky.social PhD Career Day! PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals. Looking forward to a day full of exchange, ideas, and networking! #FuturePhDs #PhDNetworking
We’re excited for tomorrow’s @crc1430.bsky.social PhD Career Day! PhD students will explore career paths in and beyond academia — from an application workshop to talks and a panel with professionals. Looking forward to a day full of exchange, ideas, and networking! #FuturePhDs #PhDNetworking