🚀 #CRC1752 #DYNAMO is preparing for its launch in October 2026! The new website is online, and the first positions are open. Join an interdisciplinary team to target the earliest mechanisms of melanoma therapy resistance. Explore & apply: www.uni-due.de/crc1752/

Over the past few weeks, several members of the #ZMB community and @crc1430.bsky.social have successfully defended their doctoral theses. Congratulations!🎓 We wish you every success in the next stage of your scientific careers and hope to stay in touch!

🧬 🔬 How do cells coordinate the forces required for successful division? A new preprint from the Nalbant lab and @icce-unidue.bsky.social colleagues provides insights by identifying a key role for Ect2 in regulating cortical contractility during cytokinesis. www.biorxiv.org/content/10.6...

Constitutive plasma membrane interaction of active Rho GEF Ect2 inhibits cortex contraction pulses

During cell division, multiple guanine nucleotide exchange factors (GEFs), including the mitotic regulator Ect2 and Lbc-type GEFs, regulate the dynamics of RhoA activity and actomyosin contractility. ...

biorxiv.org

Brilliant PhD thesis defense by Daniella Munro concluding a tour de force analysis of Ufd1-Npl4 substrates using induced-degradation. Watch out for her paper…

Our opinion article is out now on: Disentangling the response to lysosomal damage journals.biologists.com/jcs/article-... It discusses the concept of lysosome regeneration and the tools and reporters for diverse branches of the pathway. Great to work with coauthors Akiko and Shuhei.

Our evil ORFeome paper is out! In collaboration with @alex-stark.bsky.social, we screened ~4,000 viral proteins and secreted effectors from bacteria and parasites, covering hundreds of diverse pathogens, for phenotypes in human cells.

I am thrilled to share our paper out in @cp-cell.bsky.social : "Systematic Discovery of Pathogen Effector Functions across Human Pathogens and Pathways." (1/4) www.cell.com/cell/fulltex...

Systematic discovery of pathogen effector functions across human pathogens and pathways

The eORFeome, a large-scale collection of open reading frames encoding viral proteins and secreted bacterial and parasite effectors, enables functional genomics across diverse pathways and pathogens. ...

cell.com

Gina Simon, Doris Hellerschmied @hellerschmiedlab.bsky.social and colleagues @unidue-zmb.bsky.social dissect stress-induced proteome remodelling at the Golgi–endosome interface. Highlight: journals.biologists.com/jcs/article/... Article: journals.biologists.com/jcs/article/...

The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A journals.biologists.com/jcs/article/...

The Golgi vesicle tether p115/USO1 can bind directly to the ER exit site organiser Sec16A

Newly made secretory and membrane proteins exit the endoplasmic reticulum (ER) in COPII vesicles that form at specialised ER exit sites. These exit sites are typically near to the early Golgi compartm...

journals.biologists.com

After so many #notthecover one of @probablycarmen.bsky.social of a CAR T cell engaging with a cancer cell made it to the front of @embojournal.org! Want to know more about the function of protrusions in early #Tcell activation? Check out how we became accidental immunologists!

The EMBO Journal@embojournal.org · 3mo ago

In issue 10: Convergent evolution of aerobic fermentation CIN promotes migration & invasion via EFEMP1 secretion SenSet resource defines cell-type specific senescence signatures ... Cover: @franbottanelli.bsky.social and colleagues link.springer.com/journal/4431...

Great opportunity for the #ubiquitin community and fantastic speaker line-up! #ZMB member @hemmo-lab.bsky.social included, alongside many other outstanding colleagues. #EMBOubiquitin #EMBOevents 🧪

EMBO@embo.org · 3mo ago

Don't miss out! Registration is still open for the EMBO Workshop "#Ubiquitin and ubiquitin-like proteins in health and disease" in Monopoli, Italy, 28 Sep–2 Oct 2026. Registration by 31 May Abstract submission by 15 Jun https://meetings.embo.org/event/26-ubiquitin #EMBOubiquitin #EMBOevents 🧪

Gain #training on correlative #LightElectronMicroscopy techniques in the eponymous EMBO Practical Course "Correlative light electron microscopy" in Utrecht, Netherlands, 13–18 September 2026. Deadline: 3 July 2026 https://meetings.embo.org/event/26-clem #EMBOCorrelativeLight #EMBOevents 🧪

Save the date, next DGZ lunch meeting DGZ Focus Workshop Workgroup Cell Adhesion and Mechanobiology May 19, 2026 12:00 – 13:45 CEST Zoom-ID: 961 7810 6979 Passcode: DGZ_FW

Cdc48/p97 nibbling on #ubiquitin! Cool single molecule analysis study by the Tans group (with us) out now. rdcu.be/firGK

Looking forward to it!

Center of Medical Biotechnology@unidue-zmb.bsky.social · 3mo ago

Next #ZMB and @crc1430.bsky.social seminar at @unidue.bsky.social around the corner! On May 19, we’re happy to welcome @joostholthuis.bsky.social, Osnabrück University, who will present on "Lipid dynamics and function in membrane repair". See you May 19, 4.15pm, S05V01E69, Campus Essen! #CellNanOs

On June 30 at noon, the next #DGZ Focus Workshop on #MembraneOrganization & #ContactSites will take place, organized by Sabrine Buettner & Katja Zieske. Speakers: André Nadler @nadlerlab.bsky.social, Suzan Kors, Zexi Xu and Emma Fenech. Join us!

🤝 #UDE4future joins forces with the lecture series Sex and Gender in the Life Sciences 🗓 June 11, 2026, 16:00 Sex and Gender in Governance: Transformation, Megatrends and Public Health 🎤 Ricarda Schmithausen (NLGA) Further Information: lnkd.in/eZtPAkr @elh-institute.bsky.social #EKfG #SexGenderUDE

Universität Duisburg-Essen@unidue.bsky.social · 3mo ago

Die Welt wandelt sich – auch das Ruhrgebiet. Ob wir das als gemeinsames Gestaltungspotenzial wahrnehmen, ist Thema der Ringvorlesung „Resonanzräume für Transformation“ der Klimanitiative #UDE4future. Mit einer öffentlichen Diskusson am 21. Mai startet das Programm. www.uni-due.de/2026-05-05-n...

First PROTAC gains FDA approval, bolstering targeted protein degradation and induced proximity ambitions www.nature.com/articles/d41...

📢 Next Proteostasis Consortium Seminar – Wednesday 6 May 2026 at 4:00 pm GMT (10:00 am CT) 👉Link & Updates here: www.proteostasisconsortium.com/seminars/ Speaker: Adrien Rousseau (University of Dundee) Title: ‘New tools to map and manipulate proteasome assembly in cells’ #proteostasis #proteasome

Join scientists working on #ProteinHomeostasis in the EMBO Workshop "Proteostasis shaping health span: From protein folding to failure" in #Ericeira, #Portugal, 9–13 November 2026. Deadline: 1 September 2026 https://meetings.embo.org/event/26-proteostasis #EMBOproteostasis #EMBOevents 🧪

Join us tomorrow, May 5, for an exciting joint seminar with @crc1430.bsky.social at @unidue.bsky.social. We’re happy to welcome Florian Wilfling @mpibp.bsky.social, who will present on "Characterization of lysosomal damage by cryo-electron tomography." #CryoET #Lysosome

💥 New publication from the Demetriades and Nüchel groups– final version now online in EMBO reports! This Tour de force wouldn’t have worked out without the amazing support from our collaborators and core facilities!

GRASP55 maintains lysosome function by controlling sorting of lysosomal enzymes at the Golgi - EMBO Reports

Lysosomes are multifunctional organelles that play important roles in cellular recycling, signaling, and homeostasis, relying on precise trafficking and activation of lysosomal enzymes. While the Golg...

link.springer.com

It was fun writing this with David @dgershlick.bsky.social! Check it our if you want to hear our view on small #GTPases networks in endosomal trafficking :) part of the themed issue on Membrane trafficking edited by @fromme-lab.bsky.social and Philippe Chavrier www.sciencedirect.com/science/arti...

Dynamic GTPase networks reshaping endosomal organelle identities

Endosomal GTPases, while often used as markers for specific endosomal organelles, functionalize the surface of endosomal compartments into biochemical…

sciencedirect.com

Next up: Katerina Naydenova, Group Leader at the Max Planck Institute of Molecular Physiology, will present "Molecular mechanisms of #ubiquitin ligases with activity towards non-protein substrates". 📅 22 April 2026 ⏰ 12:30 📍 S05 V01 E69 ➡️ www.mpi-dortmund.mpg.de/forschungsgr...

Katerina Naydenova

Katerina Naydenova

mpi-dortmund.mpg.de

Happy Golgi Day

Why choose JCS? - FREE to publish (with OA options available) - Fast-track option for papers with reports - Submissions handled by Academic Editors - Published by a not-for-profit publisher - A tree planted for every peer-reviewed article🌳 Find out more at: journals.biologists.com/jcs/pages/re...

We offer a PostDoc position for a fully funded project on lipid-encoded #lipidtime protein quality-control checkpoints at the Golgi: great collaborators, excellent working & living conditions & benchspace with a view ;) Please share and repost!

🔬 April Webinar - Chaperones Galore! Protein folding can fail—chaperones help fix it. Learn how cells maintain protein quality from leading experts. 🗓 April 27 | ⏰ 10 AM–12 PM EDT ✨ Free + live Q&A Free registration here: us06web.zoom.us/webinar/regi...

We are accepting submissions for our upcoming special issue - Imaging Cell Architecture and Dynamics. This issue will be coordinated by @franbottanelli.bsky.social & Giulia Zanetti alongside our Editor @guijacquemet.bsky.social. Extended deadline: 1 May 2026 journals.biologists.com/jcs/pages/im...

Another talk from Berlin! Our great @franbottanelli.bsky.social 🤩 on the stage! Such beautiful live STED revealing hidden mechanisms of membrane trafficking #mk2026 @gbmev.bsky.social