After almost 6 years my PhD journey came to an end! It has been a wild ride and I’m incredibly grateful for all the things I learned and the people I have met, especially the other members of the @sendoellab.bsky.social. I am also looking forward to my next chapter at the FGCZ!

Sendoel Lab@sendoellab.bsky.social · 9mo ago

The summer of defenses comes to an end! Huge congratulations to David (@dadita.bsky.social ) on a brillant PhD and thank you for everything you have done to shape our lab community from day 1 on. We’re thrilled you’re staying in Zurich and wish you all the best in your next chapter!

Our latest monthly #preprint list is out! Have a look at the #DevBio and stem cell biology preprints that came out in July. Congrats to all authors 🎉 thenode.biologists.com/july-in-prep...

July in preprints - the Node

Welcome to our monthly trawl for developmental and stem cell biology (and related) preprints. The preprints this month are hosted on bioRxiv.

thenode.biologists.com

If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens! A big thank you to all co-authors that made this paper possible!

Sendoel Lab@sendoellab.bsky.social · last yr.

The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan. www.biorxiv.org/content/10.1...

How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!

bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last yr.

Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1

Check out this cool new preprint from our lab! Congratulations to @merveyigit.bsky.social, the hard work paid off! 🥳

Sendoel Lab@sendoellab.bsky.social · last yr.

Identified in the 1970s, the precise molecular function of the alternative initiation factor eIF2A has remained unclear. Here, we map its interactome and uncover a surprising role in ribosome-associated quality control (RQC) upon ribosome stalling. 1/x www.biorxiv.org/content/10.1...

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9

I'm thrilled to share the latest pre-print from our lab. An in vivo single-cell ribosome profiling study investigating the translational landscape of aging skin. #aging #single-cell #Ribo-sea

Sendoel Lab@sendoellab.bsky.social · 2y ago

How does aging alter the translational landscape of stem cells and how do these changes impact their regenerative capacity? Here we developed an in vivo single-cell ribosome profiling strategy to monitor translational landscapes of the mouse epidermis 1/6 www.biorxiv.org/content/10.1...