Sendoel Lab
@sendoellab.bsky.social
Sendoel lab at the University of Zurich, alumnus of the The Rockefeller University, NYC. We are excited about mRNA translation, stem cells and cancer. www.sendoellab.org
Wow what a blockbuster PhD paper by @claradure.bsky.social with @sendoellab.bsky.social . It is a must read! 👇
Clara Duré@claradure.bsky.social · 2mo agoWhat perfect timing - exactly one year after my PhD defense, I’m very happy to see my PhD work published in @cp-molcell.bsky.social. Huge thanks to @sendoellab.bsky.social and all co-authors. This would not have been possible without you 🎉
What perfect timing - exactly one year after my PhD defense, I’m very happy to see my PhD work published in @cp-molcell.bsky.social. Huge thanks to @sendoellab.bsky.social and all co-authors. This would not have been possible without you 🎉
Sendoel Lab@sendoellab.bsky.social · 3mo agoVery happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @cp-molcell.bsky.social. Fantastic work by @claradure.bsky.social and all co-authors involved. www.cell.com/molecular-ce...
Very happy to see our study on the development of an in vivo single-cell ribosome profiling strategy for the epidermis now online at @cp-molcell.bsky.social. Fantastic work by @claradure.bsky.social and all co-authors involved. www.cell.com/molecular-ce...
In vivo single-cell ribosome profiling reveals cell-type-specific translational programs during aging
In vivo single-cell ribosome profiling reveals cell-type-specific translational landscapes across the epidermis and uncovers selective reprogramming of AP-1 subunit translation in aged stem cells, lin...
cell.com
Major new work by the #TransCODE Consortium out today in @nature.com. Read all about our efforts to shed light onto the forgotten areas of the human proteome. #Microproteins #Peptideins #DarkProteome This was a huge global collaboration, in part funded via #NIH www.nature.com/articles/s41... 1/
Expanding the human proteome with microproteins and peptideins - Nature
A large-scale proteomics analysis of the dark proteome by the TransCODE Consortium reveals many translated non-canonical open reading frames to encode microproteins and peptideins.
nature.com
Excited about translational control and RNA biology? We have an open postdoc position to advance single-cell ribosome profiling, come join us. jobs.uzh.ch/job-vacancie...
UZH: Postdoctoral Researcher in translational control
The Sendoel lab studies the role of translational control in health and disease. Our lab employs a variety of in vivo techniques to investigate stem cell behavior in homeostasis, clonal expansions and...
jobs.uzh.ch
Time for some fun! A lovely paper on mathematical oncology. 🧪 #Math #Cancer #CANsky www.biorxiv.org/content/10.6...
75 Years of Mathematical Oncology
Mathematics has long provided a quantitative framework to interpret cancer biology and treatment. Driven by richer biological and clinical data, the field has evolved into a multidisciplinary and translational endeavor - giving rise to Mathematical Oncology. Yet, the field's strong interdisciplinarity obscures a comprehensive view of its evolution, as well as the boundaries between Mathematical Oncology and adjacent domains. Here, we address this gap through a comprehensive bibliometric analysis spanning 75 years of mathematical research in oncology. Using a manually curated corpus (~1,500 papers) and a large query-based dataset (~19,000 papers), we map the field's conceptual and collaborative development over time. Independent analyses reveal sustained growth, high impact, and pronounced interdisciplinarity, together with a gradual shift from fundamental cancer biology toward therapeutic modeling. This reorientation underpins the emergence of Mathematical Oncology as a distinct field, separate from Systems Biology and Pharmacokinetics / Pharmacodynamics. We show how diverse concepts interlace within Mathematical Oncology, bridging applied mathematics, optimal control, evolutionary theory, and imaging. Collectively, we demonstrate that Mathematical Oncology is not merely the application of mathematics to cancer, but the use of interpretable models integrating clinical, biological, and physical knowledge to improve screening, understand disease evolution, guide therapy, and strengthen forecasting. ### Competing Interest Statement The authors have declared no competing interest. NCI, U54CA274507 Wenner-Gren Stiftelserna/the Wenner-Gren Foundations, WGF2022-0044 Cancer Prevention Research Institute of Texas, RP220225 National Science Foundation, DMS 2436499 MICIU/AEI/10.13039/501100011033 and ERDF/EU, PID2023-146347OA-I00 MICIU/AEI/10.13039/501100011033 and ESF+, RYC2022-036010-I
biorxiv.org
Interested in gene expression analysis, single-cell biology or CRISPR screenings? We are looking for a skilled bioinformatician to join our collaborative and fun team. If interested, get in touch here: jobs.uzh.ch/job-vacancie...
UZH: Postdoc in Bioinformatics or Bioinformatician
Our lab at the University of Zurich studies the regulation of gene expression in stem cells and cancer. We are seeking a highly motivated and independent bioinformatician or postdoctoral researcher to...
jobs.uzh.ch
I go away for a short walk and come back to this.
Bill Grueskin@bgrueskin.bsky.social · 7mo agoPowell, showing more guts than almost any GOP legislators: "The threat of criminal charges is a consequence of the Fed setting interest rates based on our best assessment of what will serve the public, rather than following the preferences of the President." www.federalreserve.gov/newsevents/s...
On this national day of mourning across Switzerland for the victims of the Crans-Montana tragedy, we remember all those who were lost, all who are gravely injured, their families and loved ones, the rescuers, and medical teams caring for them Such a heartbreaking loss of young lives in our region 💔
Nanopore sequencing of peptides, exciting possibilities ahead also for the microprotein field.
Cees Dekker@ceesdekker.bsky.social · 7mo agoLatest #CDlab paper on nanopore protein sequencing now published in JACS: pubs.acs.org/doi/full/10.... Here, Justas Ritmejeris, Xiuqi Chen, collaborator Bauke Albada, and me developed a conjugation chemistry strategy for nanopore sequencing of natural peptides!
Multidisciplinary training, over time, produces the highest impact people www.science.org/doi/10.1126/...
Recent discoveries on the acquisition of the highest levels of human performance
Scientists have long debated the origins of exceptional human achievements. This literature review summarizes recent evidence from multiple domains on the acquisition of world-class performance. We re...
science.org
"This promise of an AI future, is really just a collective anxiety that wealthy people have about how well they're gonna be able to control us in the future." - @tressiemcphd.bsky.social with an absolute mic drop moment about AI bullshit. Incredible words. Listen to all of it!
We wrote two reviews on cell migration, published today in Nature Methods. They provides practical guidelines how to select a cell-migration assay and how to analyze cell-migration data Review 1: nature.com/articles/s41... Review 2: nature.com/articles/s41...
Thank you @erc.europa.eu and the panel for supporting our project RIBOSCOPE! Above all, thank you to all past & present lab members whose dedication made this possible. We are excited to push single-cell technologies to map the translational landscape of cancer. #ERCCoG
European Research Council (ERC)@erc.europa.eu · 8mo agoThe results of the ERC Consolidator Grant call have been announced! 📣 349 researchers have been selected for funding. Congratulations to all! #ERCCogG! 👉 buff.ly/uu62uFV #FrontierResearch #EUfunded #HorizonEurope @scienceinnovation.ec.europa.eu
The summer of defenses comes to an end! Huge congratulations to David (@dadita.bsky.social ) on a brillant PhD and thank you for everything you have done to shape our lab community from day 1 on. We’re thrilled you’re staying in Zurich and wish you all the best in your next chapter!
Our first PhD generation is flying out of the nest. Thank you Merve and Clara for shaping our lab from day one on. Wishing you all the best in your next chapters, we’re excited to see what comes next for you!
🔬✨ Join us this Saturday (September 6) | 16:00-23:00 at Nacht der Forschung 2025 at the University of Bern ✨ Come and check out our booth "RNA – Master of Versatility" 👩🔬 Meet our researchers & enjoy pipetted cocktails at the reproduzierBAR! www.nachtderforschung.unibe.ch #ndfunibern @unibe.ch
If you are interested in #DevBio, #organoids, #gastruloids or #CRISPR, check out the tweetorial to our new preprint on uncovering novel regulators of body plan formation in gastruloids using single cell CRISPR screens! A big thank you to all co-authors that made this paper possible!
Sendoel Lab@sendoellab.bsky.social · 12mo agoThe establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan. www.biorxiv.org/content/10.1...
The authors report that all seven tested deep learning models failed to outperform simple baselines in predicting transcriptome changes after single or double perturbations. I will duck for cover.
Genome-wide chromatin recording resolves dynamic cell state changes https://www.biorxiv.org/content/10.1101/2025.08.05.668773v1
The establishment of the body plan during gastrulation is a hallmark of animal life, yet much of its regulation remains unclear. Here, we combine gastruloids and single-cell CRISPR screenings to uncover new regulators of the body plan. www.biorxiv.org/content/10.1...
Third defense this summer officially in the books. Huge congrats to Fabiola for a brilliant presentation and defense! #Summerofdefenses
….and more #gastruloid preprint with proof of how to use their robustness and scalabiliy in high throughput screens to learn about #posttranscriptional regulation of gene expression @ Sendoel and Lutolf labs www.biorxiv.org/content/10.1...
Preprint by the @sendoellab.bsky.social in collab w/ the Lutolf & Zavolan labs w/1st author David Taborsky "Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids" @biorxivpreprint.bsky.social buff.ly/mL3a71T @dadita.bsky.socia @mihaelazavolan.bsky.social
How can we identify novel regulators of germ layer differentiation and body patterning? I am happy to announce that my preprint using single-cell CRISPR screens in gastruloids to answer this question is now online! Thank you to the rest of the @sendoellab.bsky.social and all coauthors!
bioRxiv Developmental Biology@biorxiv-devbio.bsky.social · last yr.Regulation of mRNA polyadenylation governs mammalian body plan formation in gastruloids https://www.biorxiv.org/content/10.1101/2025.07.22.666114v1
PhDone 🥳🎓 The last few years was full of successes, failures, ups and downs, but also full of amazing people, countless talks, great conferences, incredible science and endless support from my supervisor and my thesis committee. Thanks to all people who helped me in this amazing journey! #eIF2A
Sendoel Lab@sendoellab.bsky.social · last yr.The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
The summer of defenses continues, huge congratulations Dr. Yigit for a superbly delivered talk and an excellent defense!
