🚨Proud to share the preprint from my postdoc in Yves Gaudin’s lab, in collab with Frédéric Rieux-Laucat’s lab. 🧠Our key finding?
 NAP1 plays a dual role in regulating innate immunity. 📌This work highlights how phase separation modulates antiviral responses and explains some interferonopathies. 🔗⬇️
NAP1 switches from an activator to a limiter of interferon induction by trapping TBK1 in condensates
TBK1 kinase is a central regulator of type I IFN production. Upon activation of the IFN-β induction pathway, TBK1-adaptor proteins (NAP1, SINTBAD, TANK) form condensates with liquid properties. We sho...
biorxiv.org
