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Daniel Cazares

@danielcazares.bsky.social

Research associate at The Department of Biology, University of Oxford. Microbial Ecology and Evolution. Obsessed with Phages and Plasmids

8 Posts59 Follower71 Folgt
Craig MacLean@craigmaclean.bsky.social · last mo.

Projects working with Helen Alexander www.pnas.org/doi/10.1073/... and Raf www.nature.com/articles/s41... inspired me to think about this problem and I look forward to hearing your thoughts #microsky PS: I also don't think that heteroresistance is real

Stochastic bacterial population dynamics restrict the establishment of antibiotic resistance from single cells | PNAS

A better understanding of how antibiotic exposure impacts the evolution of resistance in bacterial populations is crucial for designing more sustai...

pnas.org

Craig MacLean@craigmaclean.bsky.social · last mo.

New #microsky#AMR Perspective paper with @penamiller.bsky.social rdcu.be/fqBJo ANTIBIOTIC RESISTANCE (IE MIC) AND TOLERANCE ARE NOT BACTERIAL TRAITS! Please read on if you want an explanation for this provocative claim.

Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells

Nature Communications - Beyond resistance and tolerance: rethinking evolutionary responses to antibiotics from the perspective of individual bacterial cells

rdcu.be

Sofya Garushyants@garushyants.bsky.social · 2mo ago

Our paper on the YprA family of helicases and their roles in bacterial defence is now out! We describe ARMADA, a defence system synergise with Druantia and show that both systems spread horizontally on a novel type of mobile genetic element that we call SPIDERs www.sciencedirect.com/science/arti...

YprA-family helicases provide the missing link between diverse prokaryotic immune systems

Bacteria and archaea possess an enormous variety of antiviral immune systems that often share homologous proteins and domains. YprA-family helicases a…

sciencedirect.com

Caro Kobras 🐍@carokobras.bsky.social · 2mo ago

New paper 🧪🧬🧫GeneScanner is our new tool to profile genetic variation in bacterial populations. Use via GitHub or @pubmlst.org. Thanks to Ko and Pri @sheppardlab.bsky.social @broncio.bsky.social @kjolley.bsky.social @microbiologysociety.org @imibirmingham.bsky.social @ineosoxford.bsky.social

GeneScanner: profiling genetic variation across bacterial populations

Rapid, low-cost genome sequencing has transformed microbiology, advancing efforts to link genetic and phenotypic variation across diverse bacterial systems. Laboratory functional screens now uncover c...

microbiologyresearch.org

Julia Frunzke@frunzkelab.bsky.social · 2mo ago

Now out in @pnas.org 🥳 "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" --> bad timing can kill you, even as a virus. www.pnas.org/doi/10.1073/... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de

PNAS

Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...

pnas.org

Julia Frunzke@frunzkelab.bsky.social · 7mo ago

Happy to share our recent preprint: "DNA-intercalating antiphage molecules trigger abortive infection through mutual destruction and synergize with bacterial immunity" www.biorxiv.org/content/10.6... @spp2330.bsky.social, @mibinet.bsky.social, @dfg.de @hhu.de @fzj.bsky.social

Daniel Cazares@danielcazares.bsky.social · 2mo ago

Phage constrain multidrug resistance spread #Phage #Plasmid #AMR #EvolutionaryBiology #CraigMacLeanLab The final version of our paper is out in @isme-microbes.bsky.social academic.oup.com/ismej/articl... bsky.app/profile/dani... More exciting phage and plasmid research coming soon!

Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug-resistance plasmids

Abstract. Phage therapy offers an alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are promising the

academic.oup.com

Daniel Cazares@danielcazares.bsky.social · 3mo ago

Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme... Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance

Daniel Cazares@danielcazares.bsky.social · 3mo ago

Happy to share that our latest research on the eco-evolutionary dynamics of MDR plasmids and PDPs is now out (open access vAuthor) in The ISME Journal doi.org/10.1093/isme... Here, we explored how plasmid-dependent phages (PDPs) act as a selective pressure against the spread of multidrug resistance

Eco-evolutionary responses to plasmid-dependent phage constrain the spread of multidrug resistance plasmids

Abstract. Phage therapy offers a promising alternative to antibiotics for treating multidrug-resistant infections. Plasmid-dependent phages (PDPs) are part

doi.org