Ribosomal RNA is modified at key locations. Not much happens when you remove them one by one, but what about removing them en masse around the catalytic center? The catalytic efficiency drops and the RNA forms misfolded conformations. Collaboration with the Remme Lab. @narjournal.bsky.social
23S rRNA modifications stimulate catalytic activity and prevent the formation of alternative structures
Abstract. Ribosomal RNA (rRNA) modifications cluster around the peptidyl transferase centre (PTC), the catalytic centre of the ribosome, yet their collecti
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