Notable study. Safety profiling of CAR-T cells using an organotypic human tissue platform #science #immunology #tumor #immunotherapy www.biorxiv.org/content/10.6...

As I’ve pointed out many times before immunologically relevant mutations cannot be viewed in isolation since mutation-driven changes in the microbiota can indirectly influence the phenotype. Mutation → altered microbiota → phenotype #immunology www.biorxiv.org/content/10.1...

The Weekend Tunes Qorali & Shina - So Many Times (🇬🇪 Georgia 🇹🇷 Türkiye 🇳🇬 Nigeria) What a great collaboration! A beautiful blend of Georgian ballad and Nigerian gospel music. Shared for educational/commentary purposes only. #WorldMusic 🌍🎧 #MusicUnites ❤️🎵 youtu.be/3WP9WszKA7M?...

"White Slaves: The Last Voices" by Elbruz Aksoy is a remarkable book about "white slaves" in the Ottoman Empire. It explores the Caucasus slave trade where many enslaved people were labeled "Circassians" and the lasting legacy of slavery in Turkey into the mid-20th century.

If bile acid metabolites are the mechanism by which the microbiota affects allergy, then administer those metabolites directly and see if they reproduce the phenotype. Why bother with fecal microbiota transplantation (FMT)? #science #immunology #allergy www.science.org/doi/10.1126/...

Fecal microbiome transplant in food allergy in humans and mice identifies a role for bile acid metabolites in oral tolerance

Fecal microbiome transplant up-regulates immune tolerance pathways in food allergy.

buff.ly

The Weekend Tunes Luk3, Cristina Lora - MELODRAMMATICA (🇮🇹 Italy 🇪🇸 Spain) Why does Luk3 sound like an Eastern European speaking Italian at the beginning? Style, local accent, or just me? Shared for educational/commentary purposes only. #WorldMusic 🌍🎧 #MusicUnites ❤️🎵

Was this in effect a private bailout to prevent a panic sell-off in AI stocks? #AI www.ft.com/content/5fb4...

1/ (1-17) In this thread I give my take on the new Immunity paper from the Benoist & Mathis lab on the role of TCR specificity in pTreg induction. #science #immunology #Treg #Foxp3 cell.com/immunity/ful...

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation

Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation. ...

cell.com

After a long paper drought, this article is worth reading and could be a good candidate for a Twitter/X thread explaining the key findings. #science #immunology #tolerance #Foxp3 #microbiota #antigen www.cell.com/immunity/ful...

TCR origin and specificity to environmental or self-antigens on distinct antigen-presenting cells determine peripheral Treg cell differentiation

Using CRISPR-based TCR editing, Chi et al. systematically compare gut TCRs recognizing dietary, microbial, and self-antigens to define the principles that govern peripheral Treg cell differentiation.…

cell.com

The Weekend Tunes Edward Sanda - Una Ca Ea (🇷🇴 Romania) Her shy and unsure moves and poses make this video incredibly charming considering she's his wife and a singer herself. Shared for educational/commentary purposes only. #WorldMusic 🌍🎧 #MusicUnites ❤️🎵 www.youtube.com/watch?v=oqEt...

The Weekend Tunes უსასრულო გზა — შენამდე (Endless Road to You) (🇬🇪 Georgia) It's AI-synthesized, but it's pretty good. Credited to Gocha Mumladze. Shared for educational/commentary purposes only. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 www.youtube.com/watch?v=14X1...

I find the authors' argument a bit strange. They say immunotherapy increases pro-tumorigenic PGE2 production via ATP. If this is generalizable, then how is an anti-tumor effect still observed? Not a single word about it. Poor discussion. #immunology www.cell.com/immunity/ful...

Extracellular ATP-P2RY2 signaling drives intratumoral prostaglandin E2 accumulation and adaptive resistance to immunotherapy in solid tumors

Extracellular ATP (eATP) is associated with immune suppression in the tumor microenvironment (TME) via its metabolite adenosine. Hu et al. find that immunotherapy increases eATP within the TME and…

buff.ly

Look what X is saying in the right sidebar under today's news: 'England defeats Argentina.' #FIFAWorldCup2026

It's really something to watch Argentina do nothing for 75 minutes, then suddenly find a way to win in the last 15 minutes, and every team keeps falling for it again and again. #FIFAWolrdcup2026

The Weekend Tunes manifest X Ajda Pekkan - Hileli (🇹🇷 Türkiye) finally Türkiye has a girl group that could take the world by storm. This video even has its own Diva from The Fifth Element. Shared for educational/commentary purposes only. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 youtu.be/kXKhNI4DLHM?...

8 teams remain in the World Cup. Chinese astrology says 2026 is a Fire Horse year, just like 1966, the year England won their first World Cup. If the pattern continues, we could see another first time champion this year. 👀 🏆 #FIFAWorldCup

Chinese labs got so rich that they started doing what Western labs have been doing for a long time: running experiments with zero translational relevance simply because the experiments seemed "smart." #science #immunology www.science.org/doi/10.1126/...

Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy @nature.com @mcgilluniversity.bsky.social www.nature.com/articles/s41...

A surprising and counterintuitive observation: a diet that promotes obesity enhances tumor control during immune checkpoint inhibitor therapy. #science #immunology #tumor #immunotherapy #gut #microbiota www.nature.com/articles/s41...

Diet–microbiome synergy underlies obesity-associated immunotherapy efficacy - Nature

Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models and…

nature.com

The other day I cited a paper arguing that LEF1 determines exhausted T-cell fate. Now this paper proposes a different marker. Immunology has become so fragmented that everyone seems to have their own marker. #science #immunology www.nature.com/articles/s41...

Mapping self-associating chromatin hubs identifies Id proteins as key determinants of exhausted CD8+ T cell fate - Nature Immunology

Xue et al. describe the dynamics of chromatin architecture during exhausted CD8+ T cell fate decisions and identify Id proteins as key regulators.

nature.com

🎵 OC Reviews: Originally from Beslan, North Ossetia, singer Karina Kushtati has embraced Georgia, often performing traditional songs from across the Caucasus. https://oc-media.org/review-an-ossetian-georgian-musical-evening-with-karina-kushati/

Review | An Ossetian–Georgian musical evening with Karina Kushati

Originally from Beslan, North Ossetia, singer Karina Kushtati has embraced Georgia, often performing traditional songs from across the Caucasus.

oc-media.org

Bravo, Cape Verde! They almost beat Messi's Argentina.

The Weekend Tunes Lilit Hovhannisyan & Karo Ayrumyan - Indz Tvum A (🇦🇲 Armenia) The Armenian music industry is booming, producing some real gems. Shared for educational/commentary purposes only. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 youtu.be/1HMbcoVE4ss?...

In my view, from the perspective of adaptive immunity, responses to self and to chronic infection are fundamentally indistinguishable. Autoimmunity is an obvious failure of tolerance, and chronic infection should be viewed similarly. #immunology 1/5 www.cell.com/cell/abstrac...

The transcription factor LEF1 defines the true self-renewing stem T-cell pool: LEF1⁺TCF1hi T cells. #science #immunology www.cell.com/cell/abstrac...

LEF1 and niche factors determine T cell stemness across chronic diseases

In settings of persistent antigen, such as autoimmunity and chronic infection, stem-like CD8 T cells sustain antigen-specific immune responses. Here, LEF1 and niche-derived factors are identified as…

buff.ly

Although the article is framed around the origins of adaptive immunity, its primary focus on γδ T cells makes that premise questionable. While γδ T cells can recognize conserved molecular patterns, their receptor repertoire is relatively limited.. #science #immunology 1/2

in my view, the focus on the T-cell exhaustion program itself is misplaced. As long as there is a continuous supply of naïve T cells that recognize the same antigenic pool, why should exhaustion of earlier T-cell waves matter? 1/2 #science #immunology www.pnas.org/doi/10.1073/...

Ford hired 350 experienced workers after their AI quality control systems didn’t work out. Their job ironically — train younger staff and AI tools, per Bloomberg. Ford CEO says new and improved “human system” is cutting down costs on warranty coverage and recalls, saving hundreds of millions of $$.

Grok says Germany defeated Paraguay on penalties 🤣 #FIFAWorldCup2026

The Weekend Tunes GROSU - Мій рай (🇺🇦 Ukraine) The music is authentic, but the video seems to combine real images with AI-generated ones. Shared for educational/commentary purposes only. #WorldMusic 🌍 🎧 #MusicUnites ❤️🎵 youtu.be/mrFzeMmZFUs?...