Daniela C. Soto

@dcsoto.bsky.social

Postdoctoral scholar at UCSB. HHMI Hanna Gray Fellow. Human brain evolution. Long-read sequencing enthusiast. dcsoto.github.io

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The Cech Fellows Program is a paid, nine-week summer research experience empowering the next generation of scientific leaders.

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Outstanding work by @dcsoto.bsky.social @jmuribescr.bsky.social @mydennis.bsky.social (and other collaborators) that massively advances identification of human gene duplicates, with links to important traits and our evolution. So happy to have contributed a bit to this fantastic paper.

Megan Dennis@mydennis.bsky.social · last yr.

Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...

Landmark study using #PacBio #HiFiSequencing reveals human-specific genetic variation not detectable with short reads. Researchers uncover new insights into brain evolution and potential links to cognition and autism. Read the full paper: bit.ly/3IxQtPR #BrainResearch

Human-specific gene expansions contribute to brain evolution

A complete human genome and functional modeling in zebrafish pinpoint gene expansions that may underlie the evolutionary innovations of the human brain.

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Thrilled that our study on human gene duplications and brain evolution is out! It was a true labor of love, with special shout-outs to my co-first author @jmuribescr.bsky.social and my PhD mentor @mydennis.bsky.social. Huge thanks as well to @aidaandres.bsky.social for all the popgen wisdom!

Megan Dennis@mydennis.bsky.social · last yr.

Check out our latest work co-led by @dcsoto.bsky.social and @jmuribescr.bsky.social identifying hundreds of human duplicated gene families using the new T2T-CHM13 assembly, with a focus on those potentially contributing to brain evolution 🧪: authors.elsevier.com/a/1lTQtL7PXu...

Check out our new preprint describing CiFi - a method that couples 3C and PacBio HiFi sequencing with low input requirements. We apply it to human GM12878 to better characterize chromatin across repetitive regions, as well as single insect samples (a mosquito and a Mediterranean fruit fly).

bioRxiv Genomics@biorxiv-genomic.bsky.social · last yr.

CiFi: Accurate long-read chromatin conformation capture with low-input requirements https://www.biorxiv.org/content/10.1101/2025.01.31.635566v1

The biggest congrats to former Dennis lab grad student Daniela Soto being named an HHMI Hanna Gray fellow!!! Soooooooo freaking proud and beyond-the-moon happy for her to have received this super well-deserved honor 🤩 www.hhmi.org/news/hhmi-na...

HHMI Names the 2024 Hanna Gray Fellows | HHMI

The cohort includes early career scientists working in research areas ranging from treatment-resistant cancers to how animals evolved to live on land. The HHMI Hanna H. Gray Fellows Program provides e...

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Thrilled to have been a part of this study led by @aidaandres.bsky.social that finds evidence of genetic adaptation in chimpanzees to different habitats. Most notably signatures of positive selection in chimpanzees underlie resistance to malaria in humans (GYPA and HBB).

UCL News@uclnews.bsky.social · 2y ago

Chimpanzees bear genetic adaptations that help them thrive in their forest and savannah habitats, some of which may protect against malaria: new @science.org paper led by Prof @aidaandres.bsky.social & Harrison Ostridge @ugiatucl.bsky.social @ucllifesciences.bsky.social www.ucl.ac.uk/news/2025/ja...