Denis Karcher

@deniskarcher.bsky.social

Postdoc with Anthropocene Laboratory at the Swedish Royal Academy of Science 🏛️🔬 Science-policy-society interfaces 🌊🐠 Marine social science 🪸💡 Transdisciplinary research 📈🌐Perceptions of change in the Anthropocene

🚀 Our Nature paper on EPI-Clone is live I loved analyzing the human data - we discovered that after age 50, blood production shifts to an oligoclonal pattern, and these expansions aren’t driven by CH mutations! Dive into @larsplus.bsky.social thread for the full story & visuals.

Lars Velten@larsplus.bsky.social · last yr.

Out @nature.com: Clonal tracing with somatic epimutations 🧬 Single cell methylome encodes cell state & clonal identity 🔨 EPI-Clone reads out both (+mutations, +RNA) at scale 🩸 Clonal expansions of HSCs are universal from age 50, not driven by CH mutations doi.org/10.1038/s415... 🧵