Chris Deppmann
@deppmann.bsky.social
Neuroscientist 🧠 | Professor 📚 | Biochemistry Enthusiast 🧪 | 🔍 Mission: Train future giants in science while standing on the shoulders of those before me. 🌱 www.deppmannlab.com
Born 90 years ago today: Ferid Murad, son of an Albanian teenager who sold candy across the Balkans, spoke seven languages on under a year of schooling, and was renamed at Ellis Island. At UVA in the 1970s the son worked out why nitroglycerin stops angina: it releases nitric oxide. Nobel, 1998.
The Molecule Hunters is now a podcast — We Are Biochemistry season 2, new episode every 2 days: open.spotify.com/show/6gUAeZTYYRPzdAc84Lj4Gt The Kindle edition is now free: amazon.com/dp/B0HF9MWSHK Also: audiobook open.spotify.com/show/76t8SyjmvJWec5fTjT3mYd · textbook biochemistrypedia.com
We Are Biochemistry: The Science That Connects Us
Podcast · 1233414575 · "We Are Biochemistry: The Science That Connects Us" explores life's molecular world. This 3000-level equivalent podcast covers key topics: biomolecules, metabolism, genetic engi...
open.spotify.com
Follow up to the book post: there is a companion textbook, and it is free too. Biochemistrypedia comes out of years of teaching a large biochem course at UVA. Thirty lessons, no account, nothing to install. Drag Vmax and Km and watch the curve move. biochemistrypedia.com
We self-published a history of biochemistry book. The Molecule Hunters is 133 profiles of the people who decoded life, from a physician weighing a willow tree in the 1640s to structural biologists predicting protein folds with AI. 190 scientists, eleven parts, four centuries.
Hot off the press from my lab & @zunderlab: extrinsic apoptosis & necroptosis play tag-team in brain dev! Jiachen Shi crushed it with single-cell mass cytometry. www.biorxiv.org/content/10.1...
Extrinsic Apoptosis and Necroptosis in Telencephalic Development: A Single-Cell Mass Cytometry Study
Regulated cell death is integral to sculpting the developing brain, yet the relative contributions of extrinsic apoptosis and necroptosis remain unclear. Here, we leverage single-cell mass cytometry (...
biorxiv.org
Congrats to Sushanth Kumar on his first corresponding author paper in Glia! 🎉👏 Using single-cell mass cytometry—like doing Western blots for every individual cell—this study maps the unique signaling signatures of microglia during viral and bacterial infections. doi.org/10.1002/glia...
Characterizing Microglial Signaling Dynamics During Inflammation Using Single‐Cell Mass Cytometry
Microglia play a critical role in maintaining central nervous system (CNS) homeostasis and display remarkable plasticity in their response to inflammatory stimuli. However, the specific signaling pro....
doi.org
GLP-1 receptor agonists (GLP-1RAs) are transforming the treatment of obesity and diabetes (and more). Our recent pre-print examined next-gen small molecules mimicking GLP-1, using humanized mouse models to uncover how they interact with brain circuits driving food consumption. 1/15
Huge congrats to Lizzy et al for showing how next-gen GLP1R drugs hack your amygdala to make your dopamine neurons say 'nah' to that second slice! 🧠🍰❌ Another great collab with @aguler.bsky.social 🔥"https://www.biorxiv.org/content/10.1101/2024.12.12.628169v1
Exciting news from our lab! Amy, Eli, and the team just published a single-cell mass cytometry atlas of the developing mouse brain! 🧠 24M cells profiled, 85 unique clusters identified—shedding light on protein-level cell state dynamics. Congrats, team! rdcu.be/d30MN
A single-cell mass cytometry-based atlas of the developing mouse brain
Nature Neuroscience - In recent years, valuable mRNA-based developmental atlases of the mouse brain have been made available. Here, the authors use single-cell mass cytometry to build a...
rdcu.be
Excited to share our latest findings, now published @NatureNeuro www.nature.com/articles/s41... We found unmyelinated axons exhibit pearls-on-a-string morphology's due to their membrane mechanical properties. Threads will follow!
