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Ali D. Güler

@aguler.bsky.social

Dad, husband, member of the Güler circadian neurometabolism lab at UVA 🧪 ☘️

67 Posts287 Follower399 Folgt
Andrew Hardaway@andrewhardaway.bsky.social · 2mo ago

Our CeA GLP-1 story is now online. We've got a lot more cooking in this area and I think this will inform future circuit-guided GLP-1 therapeutics: www.sciencedirect.com/science/arti... Great job to my first PhD student, Miguel Duran, who has had a hell of a week.

The central amygdala gates exogenous glucagon-like peptide 1 signals

Nuclei within the limbic system like the central amygdala (CeA) play a critical role in mediating fear, motivation, reward, and appetitive behavior. A…

sciencedirect.com

Andrew Hardaway@andrewhardaway.bsky.social · 4mo ago

Really thrilled to share my lab's latest work where we characterize the role of the CeA in integrating exogenous GLP-1 signals. www.biorxiv.org/content/10.6...

Andrew Hardaway@andrewhardaway.bsky.social · 3mo ago

Awesome work by @aguler.bsky.social and team providing critical new insights into the mechanisms of next-gen (small molecule) GLP-1R agonists!!!! Turns out the CeA is important :) www.nature.com/articles/s41...

A brain reward circuit inhibited by next-generation weight-loss drugs in mice - Nature

Humanized glucagon-like peptide 1 receptor (GLP1R) mouse models are used to investigate the neural circuitry through which small-molecule GLP1R agonists modulate feeding, with implicati...

nature.com

Ali D. Güler@aguler.bsky.social · 4mo ago

Congratulations! Exciting work; it seems like CeA is critical for hedonic food consumption, who would have guessed 😉

Andrew Hardaway@andrewhardaway.bsky.social · 4mo ago

Chemogenetic inhibition of CeA GLP-1R neurons resulted in a strong rescue of Ex-4-mediated reductions in high fat diet intake using a hedonic intermittent access paradigm. This suggests that this cell type is playing a pivotal role in the neural circuitry mediating reductions in appetite by GLP-1s.

Andrew Hardaway@andrewhardaway.bsky.social · 4mo ago

Chemogenetic inhibition of CeA GLP-1R neurons resulted in a strong rescue of Ex-4-mediated reductions in high fat diet intake using a hedonic intermittent access paradigm. This suggests that this cell type is playing a pivotal role in the neural circuitry mediating reductions in appetite by GLP-1s.

Andrew Hardaway@andrewhardaway.bsky.social · 4mo ago

But what about the target of these drugs? Those that express the GLP-1 receptor. Turns out the CeA has many cells that express GLP-1R, enriched in the medial portion. Our initial characterization here: pubmed.ncbi.nlm.nih.gov/35002645/

Anatomical and Functional Characterization of Central Amygdala Glucagon-Like Peptide 1 Receptor Expressing Neurons - PubMed

Glucagon-like peptide 1 receptors (GLP-1Rs) are highly expressed in the brain and are responsible for mediating the acute anorexigenic actions of widely prescribed GLP-1R agonists. Neurobiological efforts to localize the hypophagic effects of GLP-1R agonists in the brain have mainly focused on the h …

pubmed.ncbi.nlm.nih.gov

Omg. WTF is Happening?@lalahaenzy.bsky.social · 6mo ago

Sir Ian McKellen performing a monologue from Shakespeare’s Sir Thomas More on the Stephen Colbert show. Never have I heard this monologue performed with such a keen sense of prescience. Nor have I ever been in this exact historical moment.TY Sir Ian, for reaching us once again. #Pinks #ProudBlue

Erik Herzog@erikherzog.bsky.social · 9mo ago

Dosing on the way down improves outcomes for glioblastoma. Thanks Maddy Frank for covering this collaboration with @oliviawalch.bsky.social and WashU grad student @mariafelicita.bsky.social. #chronotherapy #circadian #medicine source.washu.edu/2025/11/timi...

Timing may be key to effective cancer treatments

Researchers at Washington University in St. Louis find the timing of biopsy can affect how doctors diagnose tumors and when those cancers may be more sensitive to chemotherapy.

source.washu.edu

Erik Herzog@erikherzog.bsky.social · 10mo ago

#Circadian #medicine tests if treatment timing can improve patient outcomes. This paper by @mariafelicita.bsky.social @oliviawalch.bsky.social et al considers #chronodiagnostics ...how the outcome of a standard test for glioblastoma differs with time of biopsy. link.springer.com/article/10.1...

Circadian variation in MGMT promoter methylation and expression predicts sensitivity to temozolomide in glioblastoma - Journal of Neuro-Oncology

Purpose Recent studies show that glioblastoma (GBM) is more sensitive to temozolomide (TMZ) in the morning. In cells, inhibiting O6-Methylguanine-DNA-Methyltransferase (MGMT) abolished time-dependent ...

link.springer.com

Nicholas Landry@nwlandry.bsky.social · 11mo ago

Come be my colleague! Happy to answer any questions about what it's like living in Charlottesville and being in the department.

Ali D. Güler@aguler.bsky.social · 11mo ago

🚨 We’re hiring! 🧪 @uvabio.bsky.social UVA Biology is recruiting multiple tenure-track Assistant Professors in neuroscience as part of a $75M Brain & Neuroscience Initiative. 🧠 Apply by Oct 15, 2025. Start Aug 2026. 👉 apply.interfolio.com/172892 #Neuroscience #FacultyJobs #NeuroJobs #Biology #UVA

Ali D. Güler@aguler.bsky.social · 11mo ago

We welcome applicants working on: • Neural circuits & plasticity • Glia & brain interactions • Behavioral genetics & genomics …and more! Join a highly interdisciplinary department with access to state-of-the-art imaging, genomics, metabolomics, and computing resources.

Drug Monkey@drugmonkey.bsky.social · 12mo ago

It is impossible to explain to civilians how it feels to finally, FINALLY, land a clearly within-payline NIH grant score and then have it go unfunded because of all this regime bullshit. You all have my sympathies. Unfair doesn’t even begin to describe it.