🚀 BIH is recruiting for its PhD Program! Work on cutting-edge translational projects spanning immunotherapy, genomics, AI, hematopoiesis, precision medicine & more. Apply by Jan 19, 2026. 🔗 Join us in turning research into health! www.bihealth.org/en/career/wo...

Current Job Offers - BIH at Charité

Current Job Offers - Berliner Institut für Gesundheitsforschung - Charité und Max-Delbrück-Centrum

bihealth.org

🚨 New preprints from our lab!
First, we introduce Cryo-mtscATAC-seq, led by Maren (@ms-maren.bsky.social ), enabling high-throughput clonal tracing from frozen human samples by isolating nuclei with their mitochondria (“CryoCells”).
👉 www.biorxiv.org/content/10.1...

Cryo-mtscATAC-seq for single-cell mitochondrial DNA genotyping and clonal tracing in archived human tissues

High-throughput clonal tracing of primary human samples relies on naturally occurring barcodes, such as somatic mitochondrial DNA (mtDNA) mutations detected via single-cell ATAC-seq (mtscATAC-seq). Fr...

biorxiv.org

Exciting new method to decellularize human brain tissue - opening up ways to study stem cell differentiation or how the ECM shapes immune responses. Great work by Roemel Jeusep Bueno and team! www.frontiersin.org/journals/bio...

Frontiers | Generation of decellularized human brain tissue for investigating cell-matrix interactions: a proof-of-concept study

The brain extracellular matrix (ECM) regulates myelin repair and regeneration following a demyelinating event by interacting with neuronal progenitors and im...

frontiersin.org

We had two great 'Night Science' workshops on the creative scientific process in Heidelberg yesterday (at EMBL and at the EMBO PhD Course). Here are the slides if you're interested in running something like this at your place! docs.google.com/presentation...

Check out our CRISPR/Cas9 methods paper, online on arxiv! 🚀🧬

Fran Bottanelli@franbottanelli.bsky.social · 2y ago

Long in the making but our protocol for gene editing is online! FAB CRISPR is super easy and allows the generation of N and C terminal fusions with TurboID, SNAP, Halo and mStayGold. A single cloninf step to generate HDR templates! arxiv.org/abs/2502.12675 1/n

Interested in 'Mitochondrial single cell-multi-omics for lineage tracing and genetics'? Apply for our free workshop in Berlin following our #ISCO2025 conference! www.isco-conference.eu www.mdc-berlin.de/news/events/...

Mitochondrial single cell-multi-omics for lineage tracing and genetics

mdc-berlin.de

Join us to connect with the vibrant #singlecell community. 📢Register for the #ISCO'25 Conference "Innovations in #SingleCell #OMICS" in Berlin! 🗓️ 12-13 May 2025 🎤 Fantastic Keynote and Invited Speakers 🫵🏿 Many slots for talks: submit your abstract 🔗http://isco-conference.eu Please spread the word!

Spatial multi-omics has just gone to the next level! www.nature.com/articles/s41... www.nature.com/articles/s41... —Integration of 5 omic modalities w/ spatial resolution at 20 -50 μm —"a new era for characterizing tissue & cellular heterogeneity that single-modality studies alone could not reveal"

#savebraincity Science, Education, and Culture is worth spending Money on!

A Review in Nature Reviews Genetics discusses how biobanks facilitate genetics research towards advancing precision medicine and overviews potential solutions to their current limitations. https://go.nature.com/3OLSnw1 🔒

The December issue of Nature Neuroscience is now live, featuring our Focus on Single-Cell Genomics! We hope that these consensus reviews from experts in the field will serve as a useful guide for neuroscientists regarding best practices for these approaches. www.nature.com/neuro/volume...