Tessera
Folgen

Aiswarya Sajeevan

@aiswaryasajeevan.bsky.social

PhD student @sophiemartinlab.bsky.social at UniGe. I like watching fission yeast cells fuse!🔬

0 Posts89 Follower222 Folgt
Sophie G Martin@sophiemartinlab.bsky.social · 5mo ago

Distinct #Cdc42 protein levels differentially regulate polarized growth and cell fusion in Schizosaccharomyces pombe The work of @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social, with Laura Merlini and Vincent Vincenzetti, now out in @plosbiology.org ! @biology-unige.bsky.social

PLOS Biology@plosbiology.org · 5mo ago

Polarized growth in #Spombe needs Cdc42, but what role does it play in cell fusion? @sajjitasaha.bsky.social @sophiemartinlab.bsky.social &co show that mitotic polarized growth responds linearly to Cdc42 levels, but mating involves a sharp switch-like response @plosbiology.org 🧪 plos.io/4bvGIhb

Mating fission yeast cells expressing Myo52-GFP (green), Cdc42-mCherrySW (Magenta) and mTagBFP2 expressed in P-cells (cyan). The cells fail to fuse, as shown by the cyan fusion marker confined to one of cell compartment. Image credit: Sajjita Saha.
Sajjita Saha@sajjitasaha.bsky.social · 5mo ago

Happy to see our work out in PLOS Biology. Thanks to @sophiemartinlab.bsky.social @aiswaryasajeevan.bsky.social Laura Merlini & Vincent Vincenzetti. 😊

PLOS Biology@plosbiology.org · 5mo ago

Polarized growth in #Spombe needs Cdc42, but what role does it play in cell fusion? @sajjitasaha.bsky.social @sophiemartinlab.bsky.social &co show that mitotic polarized growth responds linearly to Cdc42 levels, but mating involves a sharp switch-like response @plosbiology.org 🧪 plos.io/4bvGIhb

Mating fission yeast cells expressing Myo52-GFP (green), Cdc42-mCherrySW (Magenta) and mTagBFP2 expressed in P-cells (cyan). The cells fail to fuse, as shown by the cyan fusion marker confined to one of cell compartment. Image credit: Sajjita Saha.
Sophie G Martin@sophiemartinlab.bsky.social · last yr.

The lab is on a roll. 2nd preprint in as many weeks! High levels of Cdc42 GTPase underlie an all-or-none decision to fuse. Great team effort led by PhD students @sajjitasaha.bsky.social and @aiswaryasajeevan.bsky.social www.biorxiv.org/content/10.1... @biology-unige.bsky.social

High levels of Cdc42 GTPase underlie an all-or-none decision to fuse

Cdc42 is a Rho-family GTPase conserved across eukaryotes, where it plays essential roles in cell polarization. In single-celled yeast systems, Cdc42 is a key driver of symmetry breaking and polarized ...

biorxiv.org