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Ale Mongera

@mongeralab.bsky.social

Developmental biologist at UCL Multicellular Morphogenesis Lab http://zebrafishucl.org/mongera-lab

22 Posts440 Follower593 Folgt
Oded Rechavi@odedrechavi.bsky.social · 2mo ago

I won't pay $4,000 for a ticket to see my Knicks play in the NBA Finals for the first time in 27 years, but for some reason I routinely pay three times that much for open access to papers that I wrote myself.

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Manning Research Group@manningresearch.bsky.social · 2mo ago

The proposed new government rules for politics-based decision making on federal scientific grants will materially impact my ability to due science in the US: www.federalregister.gov/documents/20... Please reach out to your congress representatives on this: www.linkedin.com/posts/lisa-m...

Regulation for Federal Financial Assistance

The Office of Management and Budget (OMB) proposes to revise the Guidance for Federal Financial Assistance to improve government- wide policies and requirements related to the management of grants, co...

federalregister.gov

Cells & Development@cellsdev.bsky.social · 2mo ago

Massive congratulations to our Editor-in-Chief for being elected as a Fellow of the Royal Society @royalsociety.org. This is an incredible honour for our journal. @ucl.ac.uk @ucl-cdb.bsky.social

International Society of Developmental Biology@isdb.bsky.social · 2mo ago

‼️MASSIVE‼️ congratulations to Professor Roberto Mayor @mayorlab.bsky.social from UCL, who has been elected as a fellow of The Royal Society @royalsociety.org. Professor Mayor is a Professor of Developmental and Cellular Neurobiology and one of our board of directors. royalsociety.org/news/2026/05...

Amy Beedle@amybeedle.bsky.social · 3mo ago

My postdoc work with @pcusachs.bsky.social is finally out! We find that fibrillar adhesions play an important role regulating the timescales of nuclear mechanotransduction. You can read all about it here : www.nature.com/articles/s41563-026-02590-x Huge thanks to everyone involved!!

Fibrillar adhesion dynamics govern the timescales of nuclear mechano-response via the vimentin cytoskeleton - Nature Materials

Nuclear deformation and mechano-signalling are regulated by the coupling of vimentin cytoskeleton to the extracellular matrix through fibrillar adhesions, modulating the timescale of mechanotransducti...

nature.com

Alex Grigas@agrigas.bsky.social · 4mo ago

How much information does it take to fold a protein? Not much, if you use the right information! We find that residue burial, a binary label of core vs surface, encodes a protein's fold highly efficiently and even improves ESM2's structure representation. 1/8 www.biorxiv.org/content/10.6...

Residue burial encodes a protein's fold

Protein structure is controlled by a high-dimensional energy landscape, which is a function of all of the atomic coordinates of the protein. Can this landscape be accurately described by a low-dimensional representation? We find that residue core identity, a binary N-dimensional encoding indicating whether each of the N amino acids in a protein is buried in the core or not, can predict the protein's backbone conformation more efficiently than all other representations that we tested. Core identity is 4 times more efficient than previous estimates of the bits per residue needed to encode a protein's native fold, 2 times more efficient than the Cα contact map, and 1.5 times more efficient than the machine-learned embeddings from FoldSeek's 3Di. Even when the folded structure is unavailable, predicting each residue's burial from sequence yields a more accurate estimate of fold quality than predicting pairwise contacts from the same sequence information. Thus, this work emphasizes that the problem of determining a protein's native fold can be re-framed as predicting each residue's core identity. ### Competing Interest Statement The authors have declared no competing interest. Chan Zuckerberg Initiative (United States), 2023-329572 NIH, T32GM145452

biorxiv.org

Priti Agarwal@pritiagarwal.bsky.social · 7mo ago

🎉 The Developmental Mechanics Seminar Series is back! 🗓️ Thurs, Jan 22 🎙️ Opening talks: 🧬Guy Tanentzapf (UBC) — How cell adhesion molecules wire into the cytoskeleton 🌀Juan Manuel Gomez Elliff (EMBL) @gomezjm-devmech.bsky.social — Mapping tissue mechanics with Brillouin microscopy

International Developmental Mechanics Seminar Series

Please fill out the following survey if you are interested in the 2025-2026 International Zoom Seminars on Developmental Mechanics.

tinyurl.com

Ale Mongera@mongeralab.bsky.social · 8mo ago

Super cool work spearheaded by the amazing @agrigas.bsky.social! Excited for this collaboration with @manningresearch.bsky.social and for everything still to come! 🎉 Also thank you to @emaniou.bsky.social and @glgalea.bsky.social for your help!

Alex Grigas@agrigas.bsky.social · 8mo ago

How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...

Manning Research Group@manningresearch.bsky.social · 8mo ago

Very excited about this new paper out on bioRxiv, spearheaded by the fantastic Dr. Grigas in collaboration with @mongeralab.bsky.social and Galea labs.

Alex Grigas@agrigas.bsky.social · 8mo ago

How do sparse mesenchymal cells, with unique stellate arms spanning large gaps between cells, maintain their network while still flowing during development? In our new preprint we describe the avian PSM as a fluid under tension and develop new theory to explain it: www.biorxiv.org/content/10.6...