Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich: Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits. doi.org/10.1007/s002...

Exploring the origins of frequent tau-PET signal in vermal and adjacent regions - European Journal of Nuclear Medicine and Molecular Imaging

Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...

doi.org

Happy to share our new preprint led by Johannes Gnörich and @matthiasbrendel.bsky.social, showcasing a full ATN staging approach using a single dynamic PI-2620 scan, leveraging advanced kinetic modelling techniques www.medrxiv.org/content/10.1...

New paper alert: A two-cutoff CSF Aβ42/40 approach improves Aβ detection in real world clinical settings. CSF Aβ42/40≥7.1 rules out amyloid, while ratios~5.5–7.1 benefit from Aβ PET. Key for Lecanemab stratification. #Alzheimers #Biomarkers 📄read more: doi.org/10.1002/dad2...

Happy to share our new work led by Johannes Gnörich and Matthias Brendel, suggesting a visual read algorithm for PI-2620 in 4R taupathies. Early imaging windows, kinetic modelling and basal ganglia are key! doi.org/10.1016/j.ne...

Happy to share Davina Biels newest work in @embomolmed.bsky.social, showing stronger Aβ-dependent p-tau increases in women, potentially driven by elevated sTREM2-related microglial activation and stronger effects of ApoE4 carriership in women Many thanks also to co-senior Matthias Brendel!

Female sex is linked to a stronger association between sTREM2 and CSF p-tau in Alzheimer’s disease | EMBO Molecular Medicine

imageimageThis study examined whether sex, age, microglial activation or ApoE4 modulates the Aβ to p-tau axis, a critical event in the amyloid cascade that triggers the progression of Alzheimer’s disease (AD) from amyloidosis towards tauopathy. ...

doi.org

Massive paper alert: We performed extensive profiling of PI-2620 for 4R tauopathies. PI-2620 tau PET signals in PSP stem from neuronal and oligodendroglial tau, not astrocytes. Signals correlate with fibrillary tau, autoradiography, and autopsy data in PSP doi.org/10.1007/s004...

Neuronal and oligodendroglial, but not astroglial, tau translates to in vivo tau PET signals in individuals with primary tauopathies - Acta Neuropathologica

Tau PET has attracted increasing interest as an imaging biomarker for 4-repeat (4R)-tauopathy progressive supranuclear palsy (PSP). However, the translation of in vitro 4R-tau binding to in vivo tau P...

doi.org