neuromapr 0.2.1 has been accepted and published on CRAN! Very excited to get this out to users in the simplest way possible, and hope the #rstats #neuroimaging community finds it useful! lcbc-uio.github.io/neuromapr/

Spatial Null Models and Transforms for Brain Map Comparison

Implements spatial null models and coordinate-space transformations for statistical comparison of brain maps, following the framework described in Markello et al. (2022)…

lcbc-uio.github.io

New paper out! We systematically compared how ATN biomarker changes track cognitive decline in AD: Tau-PET, plasma ptau217 & cortical thickness changes track cognition, amyloid-PET does not. Ptau217 = cost-effective proxy for monitoring cognitive changes in AD doi.org/10.1002/alz....

A systematic comparison of ATN biomarkers for monitoring longitudinal cognitive changes in Alzheimer's disease

INTRODUCTION With anti-amyloid beta (Aβ) therapies approved for Alzheimer's disease (AD), surrogate biomarkers are needed to monitor clinical treatment efficacy. Therefore, we systematically compare.....

doi.org

🚨Postdoc position open at @BarcelonaBeta🚨 We're looking someone to work on a project at the intersection of cardiovascular and neurodegenerative research 🫀🧠 Fully funded position!!! More details: www.imim.cat/media/upload... Please share! #Alzheimer's #ENDALZ

I have just dropped a new version of my academicdb project, which helps prolific researchers generate a CV automatically. Now with a web interface! If you are interested, please try it out and let me know what you think - it takes a bit of setup work but then runs easily using Docker.

GitHub - poldrack/academicdb: Project to maintain a database for CV/website rendering

Project to maintain a database for CV/website rendering - poldrack/academicdb

github.com

Out now in Brain: Our new study shows that tau deposits in Alzheimer’s disease not affect gray matter but also drive degeneration of connected white matter tracts, offering mechanistic insight into how tau disrupts brain networks academic.oup.com/brain/articl...

🔥Recent advances in #neuroimaging of #Alzheimers disease 🧠✨ dx.doi.org/10.1002/alz.... ➡️ Valuable resource for both researchers & clinicians! ➡️ ATNIV biomarkers, staging, connectomics & more ➡️ Plus: how are sex & country represented in first/last authorship? @istaart.bsky.social Neuroimaging PIA

Very happy to share our 2nd paper today, led by Lukas Frontzkowski: We developed a novel data driven reference region for PI-2620 PET tailored to assess 4R tauopathies, improving i) PSP vs. control separation and ii) PET associations with clinical scores doi.org/10.1007/s002...

Happy to share our new work by Carla Palleis in Movement Disorders showing that brain networks shape neurodegeneration patterns in PSP => This suggests that grey matter atrophy expands across connected brain regions, potentially following tau accumulation in PSP doi.org/10.1002/mds....

Alzheimer's disease drug development pipeline: 2025 - Cummings - 2025 - Alzheimer's & Dementia: Translational Research & Clinical Interventions - Wiley Online Library alz-journals.onlinelibrary.wiley.com/doi/10.1002/...

Alzheimer's disease drug development pipeline: 2025

Clinical trials for Alzheimer's disease (AD) must be registered on clinicaltrials.gov. The registry presents a variety of types of information related to the planned clinical trial. We assess clinic...

alz-journals.onlinelibrary.wiley.com

“I would like to cure brain cancer. I think that's not particularly controversial.” Be that as it may, the NIH terminated that scientist's grant. Here's a huge survey of the 2,500 grants that NIH has killed or delayed...so far. Gift link: nyti.ms/43Jz1yJ

This is a well done study! congrats www.cell.com/cell-reports...

Astrocyte induction of disease-associated microglia is suppressed by acute exposure to fAD neurons in human iPSC triple cultures

Lish et al. present a co-culture system of iPSC-derived human microglia, astrocytes, and neurons to investigate intercellular communication across different environmental and genetic contexts. Transcr...

cell.com

Hiring! We're looking for a postdoc to join my lab at the @ukdri.ac.uk @ucl.ac.uk We’re investigating neuronal and circuit dysfunction in Alzheimer's, and developing innovative new treatments. Apply here👇 shorturl.at/LpCAq

UCL – University College London

UCL is consistently ranked as one of the top ten universities in the world (QS World University Rankings 2010-2022) and is No.2 in the UK for research power (Research Excellence Framework 2021).

shorturl.at

Our latest work, published in @cellpress.bsky.social, identifies a rare soluble #tau species in human #Alzheimer’s brain that suppresses CA1 complex-spike bursting, a hippocampal neuronal firing pattern that is critical for learning and memory. www.cell.com/cell/fulltex...

Alzheimer’s disease patient-derived high-molecular-weight tau impairs bursting in hippocampal neurons

In mouse models, tau impairs neuronal complex spike bursting and associated network processes in hippocampus CA1 alongside CaV2.3 downregulation. Soluble high-molecular-weight tau species drive these ...

cell.com

Super excited to announce a PhD position on polypathology in the medial temporal lobe at the Paris Brain Institute together with @nvillain-alz.bsky.social and @robindeflores.bsky.social! offres.institutducerveau-icm.org/fr/jobs/1935... Please repost!

When I was a student, I dreamed of one day publishing in Trends In Neurosciences. So I'm proud that we had the opportunity to write an invited review on BIN1, a major genetic determinant of Alzheimer's disease that we've been working on for over 10 years. www.sciencedirect.com/science/arti...

BIN1 and Alzheimer’s disease: the tau connection

Bridging integrator 1 (BIN1) is a ubiquitously expressed protein that plays a critical role in endocytosis, trafficking and cytoskeletal dynamics. In …

sciencedirect.com

Just out in JAMA Neurol blood biomarkers are powerful—but without cognitive phenotyping, we risk more noise than signal. Plasma p-tau217 needs clinical context or we’ll end up in a false-positive factory! Clinico-biological AD is a reality! 👉🏻 jamanetwork.com/journals/jam... bsky.app/profile/vinc...

Cognitive Phenotyping and Interpretation of Alzheimer Blood Biomarkers

This cohort study investigates if the clinical phenotype of patients without dementia is associated with blood phosphorylated tau 217 interpretation.

jamanetwork.com

Vincent Planche@vincentplanche.bsky.social · 2y ago

Happy to share the work of Vincent Bouteloup, which has just been published in JAMA Neurology and presented this morning at the AD/PD Conference! jamanetwork.com/journals/jam...

We are HIRING!! Postdoc for multimodal imaging lab at Yale. If you get excited about preclinical and prodromal states, atypical Alzheimer’s, graph theory, predictive modeling, and/or baked goods at lab meetings, come join us: postdocs.yale.edu/postdoctoral... Please share with your circles!

Also out today in EJNMMI, led by @matthiasbrendel.bsky.social and Johannes Gnörich: Ever wondered about the strong PI-2620 tau-PET signal in the vermis and superior cerebellum? We found that this signal is driven by leptomeningeal melanozytes rather than tau deposits. doi.org/10.1007/s002...

Exploring the origins of frequent tau-PET signal in vermal and adjacent regions - European Journal of Nuclear Medicine and Molecular Imaging

Purpose Off-target binding remains a significant challenge in tau-PET neuroimaging. While off-targets including monoamine oxidase enzymes and neuromelanin-containing cells have been identified, recent...

doi.org

Excited to share our new work in Molecular Neurodegeneration, showing that α-synuclein co-pathology is common in Alzheimer’s and accelerates amyloid-related tau accumulation, supporting its role as a tau co-aggregation factor. doi.org/10.1186/s130...

Alpha synuclein co-pathology is associated with accelerated amyloid-driven tau accumulation in Alzheimer’s disease - Molecular Neurodegeneration

Background Aggregated alpha-Synuclein (αSyn) is a hallmark pathology in Parkinson’s disease but also one of the most common co-pathologies in Alzheimer’s disease (AD). Preclinical studies suggest that...

doi.org

Great working with Sujala Ghatamaneni, Val Lowe, and colleagues on this high resolution autoradiography study of MK-6240 and flortaucipir🧠🖥️ link.springer.com/article/10.1... @drchristinamoloney.bsky.social @davidjonesbrain.bsky.social

High resolution autoradiography of [18F]MK-6240 and [18F]Flortaucipir shows similar neurofibrillary tangle binding patterns preferentially recognizing middling neurofibrillary tangle maturity - Acta N...

Recent developments in tau positron emission tomography (PET) radiotracers have enhanced the visualization of tau aggregates in Alzheimer’s disease (AD). The maturity level of neurofibrillary tangles ...

link.springer.com

Open #Postdoc position @isd-research.bsky.social @lmumuenchen.bsky.social to develop an #iPSC-derived #BBB model. Fully funded and embedded in our international Foundation Leducq Network of Excellence www.brenda-leducq.de Experience in vascular biology or related field required. Please RP and apply

Why academia is sleepwalking into self-destruction. My editorial @brain1878.bsky.social If you agree with the sentiments please repost. It's important for all our sakes to stop the madness academic.oup.com/brain/articl...

www2.daad.de/deutschland/...

Harmit Singh Malik@harmitmalik.bsky.social · 2y ago

Many US students don’t know how to seek opportunities outside the US. With some help from our colleagues in EU and Canada, we could put together a consolidated website of PhD opportunities and scholarships outside the US, organized by field. There might still be time for this year in some places.

Zelensky is a wartime leader watching his people suffer and die under Russian attacks every day. To be lectured and lied to by Trump and Vance, as they defend the war criminal dictator committing these atrocities, is unimaginable agony. An everlasting shame for America.

Jim Sciutto@jimsciutto.bsky.social · 2y ago

Trump has not uttered a critical word about Putin but he and his VP publicly belittled the leader of the nation Putin invaded.

We did it and now it is published: A highly Lewy-fold selective and quantitative Synuclein Aggregate Amplification Assay (SAA). Huge thanks to the amazing teams at MODAG GmbH, LMU Munich, and Bologna University! rdcu.be/eaISM

Overview of all our locus coeruleus studies presented at HAI2025 - by Alzforum 💙 . Proud of our team!! Thank you @leatgrinberg.bsky.social and @drneurochic.bsky.social ! ow.ly/mGaZ50V0LBu

WOMEN and FEMALE are red flag words. (Men, male are not on the list). Let that sink in.

Darby Saxbe@darbysaxbe.bsky.social · 2y ago

🚨BREAKING. From a program officer at the National Science Foundation, a list of keywords that can cause a grant to be pulled. I will be sharing screenshots of these keywords along with a decision tree. Please share widely. This is a crisis for academic freedom & science.

Huge thanks to alzforum for covering our most recent work! Great summary! www.alzforum.org/news/researc...

Incredibly happy and proud to share our newest work in Science Transl Med showing that Aβ promotes neuronal hyperconnectivity, thereby driving tau spread across connected brain regions. Many thanks to first authors @sebroemer.bsky.social and Fabian Wagner! science.org/doi/10.1126/... Thread below

Amyloid-associated hyperconnectivity drives tau spread across connected brain regions in Alzheimer’s disease

Aβ induces neuronal hyperconnectivity, which promotes tau spreading from temporal lobe epicenters to connected brain regions in Alzheimer’s disease.

science.org