Selma Masri
@masrilab.bsky.social
Associate Professor @UC Irvine studying how circadian clocks impact immunity, metabolism, stemness, and cancer. Obsessed with wine and my plants. https://masrilaboratory.com
We are recruiting! Tenure track faculty position open in the Department of Biological Chemistry @ucirvine.bsky.social! This is a broad search for an Assistant Professor in biomedical sciences in a vibrant department in sunny Southern California! Many perks, please apply! recruit.ap.uci.edu/JPF10441
Assistant Professor of Biomedical Sciences (tenure track)
University of California, Irvine is hiring. Apply now!
recruit.ap.uci.edu
Excited to share work published in @cp-cancercell.bsky.social by @yijuan.bsky.social showing that macropinocytosis inhibition drives myCAF-to-iCAF conversion, enhancing therapeutic responses in pancreatic cancer. Thank you to our collaborators that contributed! www.sciencedirect.com/science/arti...
Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer
Pancreatic ductal adenocarcinoma (PDAC) tumors are glutamine deficient, and both tumor cells and cancer-associated fibroblasts (CAFs) rely on this ami…
sciencedirect.com
"Nature has learnt that … some staff members are screening candidates’ social-media presences to check whether they have expressed negative views about the Trump administration or been involved in diversity, equity and inclusion (DEI) efforts … at their institutions." www.nature.com/articles/d41...
Exclusive: NIH to dismiss dozens of grant reviewers to align with Trump priorities
The move would undo years of work, leaving advisory councils understaffed, and without the full expertise needed for reviews.
nature.com
A number of firsts this year including my first time participating in commencement @ucirvine.bsky.social and hooding my first 2 graduate students that have earned their PhDs!! Congratulations Valeria and Melissa! You are both amazing and this is only the beginning! 💪🧬🧪🦸♀️🦸♀️
The findings at the recent trial and today's Columbia chaos is pushing me to the edge. I just sent the following email...
Here is a link you can blast out to all of your networks to ask them to consider signing on in support of our NIH heroes. actionnetwork.org/forms/add-na... We are at 5000 folks who have signed on. But we can do better Only for people who have ever been sick or knows someone who has been.
ADD YOUR NAME: Sign the Open Letter in Support of NIH Staff
Join the courageous and committed National Institutes of Health (NIH) public servants by adding your name now.
actionnetwork.org
Looking forward to sharing our recent work at #SLEEP2025! Circadian Medicine session starting in about an hour and I’ll be discussing approaches to timing cancer immunotherapy. See you there!
Thanks to @npr.org and the Shortwave podcast for covering circadian research! It was very cool to be on the podcast and on All Things Considered. And Kudos to Chris Hall for the exciting work. www.npr.org/2025/05/29/n... www.npr.org/2025/05/30/1...
This week in science: hawks hunting, infrared contacts and immunity through the day
Berly McCoy and Regina Barber of Short Wave talk about a hawk's clever hunting strategy, contacts that allow wearers to see infrared light, and how immunity varies during the day.
npr.org
Check out our latest story @natcancer.nature.com co-led with @masrilab.bsky.social that reviews how the circadian clock intersects several aspects of cancer biology. Excited to be part of this collaborative team effort to understand impacts on DNA repair, early onset cancer, and cancer treatment 💪🧬🕔
Selma Masri@masrilab.bsky.social · last yr.Super happy to share our latest in @natcancer.nature.com co-led by @pannunziolab.bsky.social! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out! www.nature.com/articles/s43...
Super happy to share our latest in @natcancer.nature.com co-led by @pannunziolab.bsky.social! We review the complex role of the circadian clock in genome integrity, DNA repair, immunity, metabolism, and cancer with a specific focus on early-onset cancer. Check it out! www.nature.com/articles/s43...
The diverse roles of the circadian clock in cancer - Nature Cancer
Masri and colleagues review the latest studies on the influence of circadian rhythms in cancer biology, discussing possible connections between chronobiology and cancer prevention and treatment.
nature.com
Celebrating UCI school of medicine graduate students 🧪🧠 . You are the future of #science @ucirvine.bsky.social @cnlm.bsky.social @neurohoke.bsky.social
I just emailed my state representatives to support Newsom's new budget for UC. If you agree that this economic and social engine for California needs robust state support, please join me. universityofcalifornia.quorum.us/campaign/sta...
Time for Action!
Urge legislators to fund UC!
universityofcalifornia.quorum.us
We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....
The developmental factor TBX3 engages with the Wnt/β-catenin transcriptional complex in colorectal cancer to regulate metastasis genes
pnas.org
Fresh out of press: our new chapter on the TBX3/WNT liaison, and how it drives metastasis-related genes expression in colorectal cancer, out on @pnas.org Enjoy the “bluetorial” by @claudiocantu81.bsky.social below! 👇🏼 #WNT #CRC @liu.se www.pnas.org/doi/10.1073/...
PNAS
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans...
pnas.org
Claudio Cantù@claudiocantu81.bsky.social · last yr.We had previously shown that TBX3 and #WNT cooperate in limb #DevBio We now have a shocking finding, just published in @pnas.org TBX3 physically engages with β-catenin to drive metastasis genes in #ColorectalCancer (CRC) www.pnas.org/doi/epub/10....
New preprint! 🧓⚡️ Aging drives immune exclusion & metastasis in PDAC by rewiring the tumor stroma. Young CAFs ♻️ rejuvenate the aged microenvironment & restore immune infiltration. Read: www.biorxiv.org/content/10.1... #PDAC #Aging #TumorMicroenvironment #Preprint
The Aging Microenvironment as a Determinant of Immune Exclusion and Metastatic Fate in Pancreatic Cancer
Aging is a critical yet understudied determinant in pancreatic ductal adenocarcinoma (PDAC). Despite a strong epidemiological association with age, conventional PDAC preclinical models fail to capture...
biorxiv.org
Just watched this episode. John Oliver did an outstanding job breaking everything down, even what indirects costs are! It’s our job to get all this information out, especially to inform the general public. This needs to stop. Now.
Jeremy Berg@jeremymberg.bsky.social · last yr.Here is the link to the Last Week Tonight with John Oliver about RFK, Jr, public health, and HHS (including NIH) www.youtube.com/watch?v=8H34...
Sunday TV viewing...More to come later Lead story about NIH... www.paramountpressexpress.com/cbs-news-and...
Paramount Press Express | “60 MINUTES” LISTINGS FOR SUNDAY, APRIL 27
Airs 7:00-8:00 PM, ET/ PT on the CBS Television Network NIH – In its ongoing mission to shrink the federal government, the Trump administration has cut
paramountpressexpress.com
President Donald Trump’s administration appears to be killing much, if not all, of a historic initiative that was the first, and is still the largest, National Institutes of Health effort centered on the health needs of women. scim.ag/4jLeLTJ
NIH cancels its first and largest study centered on women
The Women’s Health Initiative has produced numerous influential findings
scim.ag
This breaks my heart in ways I can’t quite describe.
Mary Brandt, MD, MDiv@drmlb.bsky.social · last yr."We are close to 300 [worshipers] but nowadays we are only less than 150. People are sick at home," says Chondwe — or Pastor Billy as everyone calls him... People are falling ill because the U.S.-funded clinics where they got their HIV medications and care have suddenly been shuttered.
New STAT story about the possible new NIH grants terms and conditions www.statnews.com/2025/04/21/t...
NIH moving to ban all future grants to universities with DEI programs or Israel boycotts, document suggests
NIH appears to be preparing to prohibit the awarding of new grants to institutions that have DEI programs or boycott Israeli companies
statnews.com
www.ucdavis.edu/research/lab... @ucdavis.bsky.social @ucdavishealth.bsky.social @ucdavisplants.bsky.social @ucdaviscns.bsky.social @ucdavispsych.bsky.social
From Labs to Lives
UC Davis researchers describe the impact of their work and the life-altering consequences if federal funding for medical research were reduced or eliminated.
ucdavis.edu
STAT story about freezing all payments to Columbia, Harvard, Brown, Northwestern, Cornell, and Cornell-Weill Medicine. www.statnews.com/2025/04/18/n...
NIH said to have halted awarding of new grants to top universities
Universities whose NIH funding has been frozen may face further strain as the agency holds off awarding new grants to at least a half dozen of them, according to an internal email.
statnews.com
A presidential effort to revoke Harvard University's tax-exempt status could run up against a number of challenges, including violating federal law.
History shows revoking Harvard's tax status won't be easy — or fast
A presidential effort to revoke Harvard University's tax-exempt status could run up against a number of challenges, including violating federal law.
npr.org
The cast and crew of Pannunzio Lab season 6! Despite everything going on we continue to grow and be productive. Their excitement about science is contagious. These are the people that keep me coming in every day 💪🫀🧬
My story about @kevinh-phd.bsky.social, nutrition and metabolism scientist at N.I.H., who felt compelled to take early retirement after experiencing censorship of his work under the new administration. www.nytimes.com/2025/04/16/w...
Leading Nutrition Scientist Departs N.I.H., Citing Censorship (Gift Article)
Kevin Hall said his work on ultraprocessed foods has been “hobbled” under the Trump administration. Scientists have been raising such concerns for months.
nytimes.com
Today, we report that APOBEC3B targets unprotected single-stranded DNA at replication forks upon ATR inhibition, triggering a reaction cascade involving UNG2 and APE1 that leads to fork collapse and hyperactivation of PARP1, causing replication catastrophe. www.science.org/doi/10.1126/...
Mechanism of DNA replication fork breakage and PARP1 hyperactivation during replication catastrophe
Upon ATR inhibition, APOBEC3B targets unprotected single-stranded DNA at replication forks, leading to fork breakage.
science.org
"After nearly five hours, he and his wife were released. They are now pursuing legal action. "It's not about the immigrants," his sister, told NBC10 Boston. "It's coming to us Americans, and it's going to go after all of us." www.nbcboston.com/news/politic...
‘Treated like a criminal': US citizen says he was detained returning from Canada
Bachir Atallah, a real estate attorney from New Hampshire, says he and his wife, Jessica Fakhri, were stopped crossing from Canada into Vermont
nbcboston.com
If a student you know received an honorable mention for the NSF GRFP, encourage them to contact their Congressional representatives! 🧪
Cek@ckean02.bsky.social · 2y agoHonorable mention here — they said this in the email: “Although the agency is unable to offer fellowship support at this time, a subsequent announcement of additional awardees is possible subject to finalization of the agency's fiscal year 2025 spend plan”
