Excited to share our new paper, now published in Nature Cell Biology! 🎉 We asked a fundamental question in cell biology: How do cells maintain polarity while migrating? Especially how do cancer cells navigate confined spaces? www.nature.com/articles/s41556-026-01981-1

CD44 restricts EGFR mobility to polarize cytoskeletal signalling modules driving bleb-based migration - Nature Cell Biology

Jha et al. show that the transmembrane protein CD44 restricts EGFR mobility to maintain an EGFR–PI3K–Rac gradient during bleb-based cell migration.

nature.com

It is out 😍 check it out!! Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning. @cschwayer.bsky.social @silviabarbiero.bsky.social @davidbrueckner.bsky.social @ehannezo.bsky.social www.cell.com/cell/fulltex...

Multiscale integration of tissue and chromatin context converts cell heterogeneity into stable intestinal patterning

During regeneration, tissues must translate transient cellular variability into stable spatial organization. Tissue architecture generates a density-dependent window of heterogeneity in the mechanosen...

cell.com

An initial idea from our previous work turned into 💣💥🔥🔥🔥: Pioneering activity of WNT-beta catenin - here, we said it: look at the preprint and let us know your thoughts!! Led by Tamina Weiss, @annanordin.bsky.social , @claudiocantu81.bsky.social at @liu.se

Claudio Cantù@claudiocantu81.bsky.social · 2mo ago

FASTEN YOUR SEATBELTS: Tamina Weiss, inspired by previous data from @ppagella86.bsky.social found that beta-catenin is more than an adaptor protein downstream of #WNT It is an orchestrator that scouts and opens enhancers for transcriptional activation @biorxivpreprint.bsky.social

ICYMI from @cami-autorino.bsky.social & @nicolettapetridou.bsky.social 🐟

Nature Cell Biology@natcellbio.nature.com · 3mo ago

☕ @nicolettapetridou.bsky.social & co report a feedback loop between Nodal signaling and tissue phase transitions in zebrafish #embryos. Nodal alters adhesion, triggering tissue rigidification and reduced porosity, which limits its diffusion and speeds up Lefty expression. go.nature.com/4vgBYmo

⚡ Our paper is now out in @natphys.nature.com ! This version now includes a detailed molecular characterisation of the optogenetic perturbations, new insights on the relevance of tricellular junctions for tissue morphology, and beautiful light-sheet timelapses. 🔬 www.nature.com/articles/s41...

Adhesion-driven rigidity transition decoupled from density-driven jamming triggers epithelial organization in embryonic tissues - Nature Physics

Tissue phase transitions are key to morphogenesis. Now adhesion-driven rigidification is identified as key to epithelial organization but only if uncoupled from density-driven jamming.

nature.com

Laura Rustarazo-Calvo@laura-rustarazo.bsky.social · last yr.

🎉 Excited to share our new work: “Adhesion-driven tissue rigidification triggers epithelial cell polarity”, now on @biorxivpreprint.bsky.social ! A huge thank you to @nicolettapetridou.bsky.social, Bernat, @crisp-c.bsky.social, Adrián, and everyone involved! 🙌 🧵⤵️

‘Astrocytes connect specific brain regions through plastic networks’ Really cool @nature.com study by @melcooperphd.bsky.social @liddelowsa.bsky.social and colleagues 🧪🧠 www.nature.com/articles/s41...

Astrocytes connect specific brain regions through plastic networks - Nature

Communication between distant brain regions is mediated by plastic networks of gap junction-coupled astrocytes.

nature.com

Register to The PALS Summer School in TranscriptOMICS 👉 Before April 15 And Learn how to perform: Single-cell Multiome data analysis and integration — workflow management and reproducibility from Daniel Mouzo @qmul.bsky.social @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social

Claudio Cantù@claudiocantu81.bsky.social · 4mo ago

Register to The PALS Summer School in TranscriptOMICS 👉 Before April 15 And learn to Integrate Chromatin Accessibility w 3D Genomics w hands-on session by Luminita Ruje from @mrc-lms.bsky.social @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social www.trippus.net/summerschool...

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪 To learn about ➡️ Dynamics of immunological tissue architecture in the human gut ⬅️ by ⭐ professor Simon Koplev ⭐ from KTH @scilifelab.se @kawresearch.bsky.social @remeseiro-lab.bsky.social REGISTER NOW! www.trippus.net/summerschool...

Summer School 2026

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

trippus.net

Claudio Cantù@claudiocantu81.bsky.social · 5mo ago

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS To learn Enhancer dynamics in living Drosophila embryos by ⭐ prof Takashi Fukaya⭐ @fukayalab.bsky.social @utokyoofficial.bsky.social @kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social REGISTER www.trippus.net/summerschool...

Join 🇸🇪 🌞 The PALS Summer School in TranscriptOMICS 🧬 🧪 To learn about ➡️ Transposable elements and the human brain ⬅️ by ⭐ professor Vivien Horvath⭐ from @umeauniversitet.bsky.social @kawresearch.bsky.social @scilifelab.se @remeseiro-lab.bsky.social REGISTER NOW! www.trippus.net/summerschool...

Summer School 2026

Come to this beautiful Swedish inland scenario to learn the most advanced technologies to study transcriptional regulation.

trippus.net

Claudio Cantù@claudiocantu81.bsky.social · 6mo ago

Join The Summer School in Transcriptomics 🧬 Deadline on April 15! We cannot wait to host you in beautiful Swedish Summer 🇸🇪🌞 @remeseiro-lab.bsky.social @scilifelab.se @kawresearch.bsky.social @liu.se @umeauniversitet.bsky.social www.trippus.net/summerschool...

How do pairs of DNA loci - such as enhancers and promoters - find each other inside the nucleus? 🤔 Most models assume the random forces driving locus motion are independent in space New preprint by @janniharju.bsky.social: this assumption fails in living cells 🧵 www.biorxiv.org/content/10.6...

Our review “A competition model of multilineage priming and cell-fate decisions” is out: www.cell.com/cell-reports...

A competition model of multilineage priming and cell-fate decisions

In development, cells navigate highly complex gene-regulatory landscapes to make fate choices. Steinschaden et al. synthesize concepts of multilineage priming, microheterogeneity, and collective multi...

cell.com

Congratulations @ivaskalab.bsky.social team for this study on the role of vibration in vocal cord cancer! Was a fun collaboration 🎤🎤

Johanna Ivaska@johannaivaska.bsky.social · 6mo ago

What music should we play to our cells? This was the start of an amazing journey from @ivaskalab.bsky.social at @turkubioscience.bsky.social with Jasmin Kaivola and collaborators @sarawickstrom.bsky.social and others to explore larynx cancer mechanosensitivity! www.nature.com/articles/s41...

How do cells orchestrate themselves to achieve a directional movement as a group? Hi, I’m @sayukihirano.bsky.social. In this thread, I’ll highlight key mechanisms of how cells communicate with each other to perform directional collective migration.

Fresh pre-print: our all-human, innervated & vascularized oral cancer-on-chip, all done with fully defined extracellular matrices with controlled enrichment and degradability! 🔥 www.biorxiv.org/content/10.6...

#SpatialTranscriptomics Visium + scRNAseq Oral Squamous Cell Carcinoma vs paired Oral Leukoplakia vs normal tissues Inhibin A+ monocyte enriched in premalignant OLK lesions 1⃣Mesenchymal CAF 2⃣APOE+NRG1+ Mφ 3⃣TNFRSF4+ Treg ⬆️with tumor progression #CellDiscov 2023 www.nature.com/articles/s41...

In press: our brief review about the efforts to emulate the dental pulp using organ-on-a-chip approaches ”Dental Pulp-On-Chip” Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology - Journal of Endodontics www.jendodon.com/article/S009...

“Dental Pulp-On-Chip” Microfluidic Devices for Emulating Human Dental Pulp Tissue Physiology and Pathology

The dental pulp is a highly vascularized and innervated connective tissue located at the central part of the tooth and composed of a diverse array of cell types, including fibroblasts, multipotent mes...

jendodon.com

A majestic tour-de-force by @szczotml.bsky.social lab at @liu.se - beautiful combination of function & transcriptional identity to understand how pain is encoded across the body 👇🏼👇🏼

Marcin Szczot@szczotml.bsky.social · 8mo ago

Not all pain is created equal: stepping on a nail feels different from a stomachache. We know there are many nociceptor types, but a key question remains: how is mechanical pain encoded across the body by those sensory neurons? Our new work helps answer this. 1/8 www.biorxiv.org/content/10.6...

Mapping genome-wide binding AND protein partners of virtually any gene regulator , simultaneously, without transgenesis? YES 👇🏼👇🏼👇🏼👇🏼 Look at what @annanordin.bsky.social & @claudiocantu81.bsky.social cooked!!

Claudio Cantù@claudiocantu81.bsky.social · 8mo ago

Can one map the genome-wide binding (1) and its protein partners (2) simultaneously from the same sample? Yes, one can. with CUT&ID ✂️🪪 Spearheaded — singlehandedly — by @annanordin.bsky.social No need of transgenesis, cloning and overexpression. Check it out, it's fast and its works.

Please please read this.

Artologica aka Michele Banks @artologica.net · 8mo ago

"people have gotten so used to getting content for free or for almost nothing that they now feel entitled to everything" Please, Do Feed the Artists, by @johnpavlovitz.bsky.social

Vinculin is a simple adapter protein right? Wrong! That’s been the prevailing view for the 46 years since it was discovered. Here we provide a new paradigm and show that vinculin is a complex mechanosensor itself, containing 6 binary switch domains. www.science.org/doi/10.1126/...

The mechanical response of vinculin

Vinculin buffers force via dynamic domain unfolding/refolding under physiological load and lacks a stable head-tail lock.

science.org

Funders must recognise that great discoveries often come from studies that seeks to advance knowledge for its own sake go.nature.com/47zrzYZ

From MRI to Ozempic: breakthroughs that show why fundamental research must be protected

In these financially straitened times, funders must recognize that great discoveries often arise from work that was looking for something completely different.

go.nature.com

Tomorrow Wednesday 29th at 11am, lesson #3 of @neilshubin.bsky.social guest Professor @college-de-france.fr on ‘The evolutionary origin of bones and teeth’. The second lesson is available @ www.youtube.com/watch?v=0B6y... . No registration, Free access, dentures accepted.

"Jane Goodall showed us what a life in science could look like: rigorous discovery paired with fierce advocacy for what you study. She gave the world six decades of groundbreaking research on chimpanzees and their habitats, then turned that knowledge into a global movement for conservation." (1/2)

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence www.nature.com/articles/s43...

SMAD4 induces opposite effects on metastatic growth from pancreatic tumors depending on the organ of residence - Nature Cancer

Using mouse pancreatic cancer models, Tsanov et al. show that reactivation of SMAD4 at metastatic sites promotes tumor growth in the lung through RUNX1 but restrains metastatic growth through KLF4 in the liver, influenced by organ-specific epigenetic states.

nature.com

Thrilled to share our new paper @cp-cell.bsky.social: “Microglia–astrocyte crosstalk regulates synapse remodeling via Wnt signaling.” This work demonstrates the necessity of glia–glia communication and coordination during synapse remodeling. 🔗 www.cell.com/cell/fulltex... Faust et al., Cell 2025

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...

Open positions in bioengineering

Learn more about open scholarship positions in bioengineering at IFM.

liu.se

SOX2 and NR2F1 cooperate to make #neurons in the #Thalamus for visual input from the #retina #DevBio journals.biologists.com/bio/article/... ‪ @biologyopen.bsky.social In collab w Sara Mercurio and Silvia Nicolis @btbsunimib.bsky.social Driven by Linda Serra and @annanordin.bsky.social

SOX2 and NR2F1 coordinate the gene expression program of the early postnatal visual thalamus

Summary: The transcriptional regulators SOX2 and NR2F1 drive the development of the visual thalamus. Mutations in these genes cause visual impairment in humans.

journals.biologists.com

We are hiring! 2 years postdoctoral fellowship, to work on the generation of all-human, vascularized and innervated organ-on-chip systems & model infection & inflammation - in Sweden 🇸🇪 @liu.se Details in the link - please help me spreading the announcement! liu.se/en/organisat...

Open positions in bioengineering

Learn more about open scholarship positions in bioengineering at IFM.

liu.se

Glad to share the latest effort to emulate dental tissues on-chip: an organ-on-chip design including human dental pulp stem cells & HUVECs, odontoblasts, and a dentin powder-containing compartment, all innervated by mouse trigeminal ganglia! 👇🏼 advanced.onlinelibrary.wiley.com/doi/10.1002/...

An Innovative “Tooth‐On‐Chip” Microfluidic Device Emulating the Structure and Physiology of the Dental Pulp Tissue

This work presents a “tooth-on-chip” device that mimics dental pulp tissue. By co-culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and tr...

advanced.onlinelibrary.wiley.com

If we lose our inner ear hair cells, we lose our hearing.. but reptiles can repair their sensory organs 🐊🤩 Tune in to Vetenskapspodden on Swedish radio P1, Sun 07:03, Mon 18:33, or bit.ly/4oCDHzP from Sunday, to hear me & Helge Rask-Andersen discuss crocodiles & regeneration with Lena Nordlund!