🎯 Can gastroenterologists predict who will die in-hospital based on day-of-admission values? Yes, using the CLEARED Liver consortium w internal/external validation, VA research, and a #randomforest ML model. Read more at https://ow.ly/KjzX50XS38P 🖊️ Jasmohan Bajaj

It's finally here! Consensus #ACLF & #cirrhosis organ failure definitions. ⤵️ pubmed.ncbi.nlm.nih.gov/40499736/ Why? We need to speak the same language re #ACLF How? Multi-country consensus panels Result? Harmonized definitions &  research agenda @aasldnews.bsky.social @easlnews.bsky.social

Amazing panel discussions at the end of the EASL-ESCMID session at #EASLCongress 2025 #AMR, #liver, #cirrhosis @easlnews.bsky.social @escmid.bsky.social @esgvh.bsky.social @oana-sandulescu.bsky.social @jasmohanbajaj.bsky.social

Recent study:⬆️ #daptomycin resist w #rifaximin. But does this impact outcomes in #cirrhosis? In VA & TriNetX we found no impact of rifaximin on dapt users on 🔑30-day mortality 🔑LT 🔑sepsis dev 🔑linezolid use ✅ @amergastroassn.bsky.social ➡️ pubmed.ncbi.nlm.nih.gov/40122471/ @absteward.bsky.social

After five decades, steroid dosing in AAH is revisited: Tapered prednisolone proves superior in reducing infections. #STASH trial @jasmohanbajaj.bsky.social @juanpabloarab.bsky.social @ebtapper.bsky.social @tonybreu.bsky.social @blaneymd.medsky.social journals.lww.com/ajg/abstract... #liversky

Infections in Standard or Tapered Dose of Prednisolone for... : Official journal of the American College of Gastroenterology | ACG

mary objective was to assess the incidence of infection by day 90. The key secondary objectives were the incidence of mortality, acute kidney injury (AKI), readmissions rate and adverse events. Metho...

journals.lww.com

Unnecessary #antibiotics: #SBP prophylaxis in #cirrhosis ⬆️ #SBP & other infections! Esp #UTIs w similar🦠 latest from VA & Trinetx ⤵️ pubmed.ncbi.nlm.nih.gov/40062879/ 50% of US ❌use SBPProph..should we all follow & ⬇️ #AMR? @absteward.bsky.social @amcollegegastro.bsky.social @ebtapper.bsky.social

Thanks #CDDW #CLM Chris Rose & Premsyl Bercik for the invite to speak in a beautiful but freezing Quebec city on #HE #microbes & #gutbrainaxis. Excellent joint session with #microbiology & #gi expertise. 🇨🇦 warmth shone thru despite the polar vortex!! @vculiver.bsky.social

ASCI member @jasmohanbajaj.bsky.social et al. show that fecal transplant ameliorates a source of cirrhosis progression.

JCI Insight - Intestinal mucosal mitochondrial oxidative phosphorylation worsens with cirrhosis progression and is ameliorated with FMT

Research LetterIn-Press PreviewHepatologyMicrobiology Open Access | 10.1172/jci.insight.186649

buff.ly

Please check out this powerful statement re: #NIH by @kerialthoff.bsky.social : 🎥: www.instagram.com/reel/DF3kmec... Then go here to check out the impact for *your* state: 💰: www.unitedformedicalresearch.org/nih-in-your-... & Contact your US Sen.s/Rep.!: ☎️ : www.usa.gov/elected-offi...

NIH In Your State - United For Medical Research

Select a state on the map to see the impact of NIH funding across America.

unitedformedicalresearch.org

Metabolic risk factors are increasingly important drivers of primary liver cancer but.... it's complicated Joseph Ahn lays out the power and perils of Global Burden of Disease data in this editorial in @amcollegegastro.bsky.social #AJG editorial journals.lww.com/ajg/fulltext... #GISky #LiverSky

A Global Perspective on Metabolically Driven Primary Liver... : Official journal of the American College of Gastroenterology | ACG

An abstract is unavailable.

journals.lww.com

🙏 @paulsaxmd.bsky.social for the invitation to write this from a #liversky and #IDsky perspective @cidjournal.bsky.social Totally agree the approach needs to shift! @vculiver.bsky.social @idsainfo.bsky.social @easlnews.bsky.social @varesearch.bsky.social

Paul Sax@paulsaxmd.bsky.social · 2y ago

Before reading this excellent perspective, I had no idea that the data supporting the use of antibiotic prophylaxis for SBP were so weak. Really time to re-think this "standard-of-care" practice! Highly recommended. #IDSky doi.org/10.1093/cid/...

Wait. ONE lousy trial is the major reason for spontaneous bacterial peritonitis prophylaxis?! Thanks to @paulsaxmd.bsky.social for this! #IDSky #Medsky academic.oup.com/cid/advance-...

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis: First, Do No Harm

Abstract. Antibiotic prophylaxis for spontaneous bacterial peritonitis (SBPPr) in patients with cirrhosis has been considered standard of care since the 19

academic.oup.com

🙏 for highlighting our commentary @cidjournal.bsky.social Need to re-evaluate these practices due to ⬆️ - #amr burden - C difficile & #antibiotic adverse events - costs #liversky #gisky @varesearch.bsky.social @idsainfo.bsky.social @amcollegegastro.bsky.social @easlnews.bsky.social

Timothy Li@drtimothyli.bsky.social · 2y ago

Rethinking Antibiotic Prophylaxis for Spontaneous Bacterial Peritonitis in Patients with Cirrhosis ➡️Standard of care since the 1990s and is currently recommended by several major GI societies ➡️Weak supporting evidence ➡️No clear mortality benefit doi.org/10.1093/cid/... #IDSky

Pts w #Hepaticencephalopathy get a raw deal for #Livertransplant. Does MELD3.0 help? 🔑 we need to do more! In @varesearch.bsky.social #cirrhosis pts @amcollegegastro.bsky.social 🔑inpt HE adds >4-5 MELD3.0 points for 90D & 6-7 for 1Y mortality 🔑HE needs priority!⤵️ pubmed.ncbi.nlm.nih.gov/39836914/

Check out @nytimes.com interview of experts re: #wellness my tip? Coffee for the win!! Liver brain and microbes all benefit from this Check it out below www.nytimes.com/interactive/... @vculiver.bsky.social @amcollegegastro.bsky.social @ebtapper.bsky.social @easlnews.bsky.social

Delighted to share our recent review in @AmJGastro Clinical Implications of Inflammation in Patients With Cirrhosis journals.lww.com/ajg/fulltext... @jasmohanbajaj.bsky.social

Clinical Implications of Inflammation in Patients With... : Official journal of the American College of Gastroenterology | ACG

state with coexistent severe immune paralysis that defines acute decompensation and acute-on-chronic liver failure. Systemic inflammation plays a crucial role in the disease course of cirrhosis and is...

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