After several years of work, I'm happy to share that the main project from my PhD is now published in Nature Microbiology. We show that the skin commensal Malassezia produces tryptophan-derived indoles that activate AhR promoting skin barrier function and tissue homeostasis. doi.org/10.1038/s415...

Commensal yeast Malassezia produces tryptophan metabolites to promote tissue homeostasis via the aryl hydrocarbon receptor in mice - Nature Microbiology

A ubiquitous skin fungus, frequently associated with skin pathology, is important for maintenance of the skin barrier function through tryptophan derivatives that act as aryl hydrocarbon receptor agon...

doi.org

We’re excited to announce our next seminar on June 18 at 11:30! Join us at UZH Irchel or online for talks by @seppedeschepper.bsky.social on the gut–brain axis in Parkinson’s disease and @laura-moberbichler.bsky.social on the IRF5–PPARγ axis in neuroinflammation. See the flyer for more details.

The rules of immunity are different in early life! Lead author Dr. Yue Xing finds that early life DCs sense allergens and trigger inflammation directly in skin. This in-situ activation state emerges from a developing HPA and low glucocorticoids. #Naiklab @nature.com www.nature.com/articles/s41...

Peripheral immune-inducer dendritic cells drive early-life allergic inflammation - Nature

Early-life exposure to allergens triggers a distinct local mode of dendritic cell activation in neonatal skin without requiring migration to lymph nodes, which shapes responses to allergens in later l...

nature.com

Excited to share our lab’s latest preprint: In vivo single-cell CRISPR screening for microproteins identifies a critical ribosomal component. Check out how we systematically explore #microprotein functions and how they expand the cellular proteome!

Sendoel Lab@sendoellab.bsky.social · last yr.

Our genome encodes > 7000 microproteins that have been previously ignored in genome annotations. How do these microproteins impact tissue function? Here, we use an in vivo single-cell CRISPR screen to systematically explore microprotein function in the mouse epidermis. 1/9

Our new preprint is out on @biorxivpreprint! 🔗 www.biorxiv.org/content/10.1... This work done as part of my PhD at @lableibundgut.bsky.social We show that the commensal fungus Malassezia promotes skin barrier function via AhR signaling, through secreted tryptophan-derived indoles.

The skin commensal yeast Malassezia promotes tissue homeostasis via the aryl hydrocarbon receptor

As an abundant fungal colonizer of human skin, Malassezia has long been associated with pathological skin conditions, yet its role in skin homeostasis remain poorly understood. Here, we demonstrate th...

biorxiv.org

"Ultimately, these changes lead to insufficient activation of a pathway controlled by the aryl hydrocarbon receptor (AHR)" not to be that smug guy on the Internet but this is why I keep yelling about AhR and Regulatory T cells and immune conditions liminalnest.wordpress.com/2024/05/28/b...

Brain fog friendly version: why you should care about Regulatory T Cells (T regs)

I wanted to share some info about the immune system, dysbiosis, and food intolerances that I think might be relevant to a lot of folks. Please note that there's still a lot of scientific debate about ...

liminalnest.wordpress.com

Our first 🦋 post! Very happy to share our latest paper just out in Cell Reports, exploring the crosstalk between immune and epithelial cells in the gut. Check it out! @vivianlilab.bsky.social @kingscollegelondon.bsky.social www.cell.com/cell-reports...

IFN-γ-dependent regulation of intestinal epithelial homeostasis by NKT cells

The crosstalk between immune and epithelial cells is vital to maintain intestinal homeostasis. Lebrusant-Fernandez et al. identify NKT cells in the small intestine as key regulators of epithelial biol...

cell.com

Check out our latest work on cutaneous immunity against Malassezia. Just out in Mucosal Immunology. Congrats to Meret Tuor and colleagues. Thanks to Mark Stappers, Neil Gow and Selinda Orr for your contributions. www.sciencedirect.com/science/arti...

Card9 and MyD88 differentially regulate Th17 immunity to the commensal yeast Malassezia in the murine skin

The fungal community of the skin microbiome is dominated by a single genus, Malassezia. Besides its symbiotic lifestyle at the host interface, this co…

sciencedirect.com