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Quinn Sievers

@quinnsievers.bsky.social

Instructor in Lymphoma at Memorial Sloan Kettering and postdoc in the Abdel-Wahab and Vinogradova labs | Big problems, small molecules 🏳️‍🌈

341 Posts216 Follower164 Folgt
Kimberly Beatty@beattylab.bsky.social · 3d ago

Please share: OHSU is hiring an Assistant Prof. in the Dept. of Chemical Physiology & Biochemistry. We are looking for a chemical biologist who will apply novel chemical tools in physiological systems. Apply online: www.ohsu.edu/human-resour... (Job # 2026-41667).

OHSU Faculty, Physician and Academic Jobs in Oregon

Find higher education faculty, physician and research jobs and build your academic health career at OHSU in Portland, Oregon.

ohsu.edu

Physics Today@physicstoday.aip.org · 3w ago

With less than one month to go in the federal fiscal year, NSF has awarded 31% fewer grants in its math and physical sciences directorate than the average for 2000–24. https://physicstoday.aip.org/news/the-shrinking-nsf-support-for-the-physical-sciences?utm_campaign=PT_social

The shrinking NSF support for the physical sciences

The agency has awarded fewer grants in the physical sciences this year than most years in its history.

physicstoday.aip.org

Caroline Bartman@cbartman.bsky.social · 3w ago

Excited to share the first published paper from my lab! Postdoc Helen Jordan led this study on 1) how metabolites change differently in inflammation in tissues versus in cells in a dish and 2) the role of one of the most-increased metabolites, soluble sialic acid www.jbc.org/article/S002...

Metabolomics of in vivo inflammation identifies soluble sialic acid as a conserved myeloid-cell metabolite

During an immune response, metabolism changes dramatically. Metabolites are oxidized to power immune cell functions, serve as building blocks for proliferation, and act as effectors to regulate pathog...

jbc.org

UW–Madison School of Pharmacy@uwmadpharmacy.bsky.social · last mo.

🚨 New "McR-TACs" by Associate Professor Quanyin Hu & collabs recycle. The degrader pulls its target protein into the cell, then releases it & exits via ER–Golgi transcytosis for another round. Durable PD-L1 & MIF degradation slowed tumors in triple-negative breast #cancer model.

Nature Biotechnology@natbiotech.nature.com · last mo.

Macropinocytosis-mediated recyclable LYTACs (McR-TACs) for receptor-independent protein degradation - @uwmadpharmacy.bsky.social www.nature.com/articles/s41...

Inigo Martincorena@imartincorena.bsky.social · 4w ago

Big paper alert! This project has been years in the making. A comprehensive description of somatic mutation rates and signatures across 53 tissues or cell types using NanoSeq. A large collective effort led by Mimy Pham, Mike Stratton and @r-rahbari.bsky.social. www.biorxiv.org/content/10.6...

A comprehensive atlas of somatic mutation rates and mutational signatures in normal human cells

Over the course of a lifetime, somatic mutations accrue in normal human cells, causing variation in cell phenotype and engendering somatic evolution with outcomes ranging from the adaptive immune syst...

biorxiv.org

Steven Banik@stevenbanik.bsky.social · 4w ago

Excited our ratiometric transcriptional activation (RTA) work led by postdoc Dr. Melissa Gray is out online today in Cell @cp-cell.bsky.social! Measurements determine what we can discover in biology; we use RTA to turn protein abundance changes into amplified signals in live cells.

Ratiometric transcriptional activation by protein degradation

By tethering a protein of interest to anti-CRISPR, protein degradation is transformed into amplified and programmable transcriptional outputs via Cas-based transcription factors, with sensitivity to p...

cell.com

Ardem Patapoutian@ardemp.bskyverified.social · last mo.

NIH's Aug 2026 proposal would scrap exact scores and percentiles for three broad bins (top = top 25%). With funding rates at 5% or lower, too much then rides on administrative discretion. It devalues peer review and is a deterrent to engage. Tell NIH before Oct 13. grants.nih.gov/grants/guide...

NOT-OD-26-088: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Request for Information (RFI) on Proposed Changes to Reporting Outcomes from NIH Peer Review NOT-OD-26-088. NIH

grants.nih.gov

anil oza@aniloza.bsky.social · last mo.

OMB's proposal to remake federal grantmaking was flooded with comments Now, they are withdrawing some from the public record — including some that point out Russell Vought's connection to the federally funded research that led to Trikafta www.statnews.com/2026/08/25/r...

Comments on OMB research rule mysteriously removed from federal website

Some comments on a proposed OMB research rule have been mysteriously removed from a public-facing government webpage.

statnews.com

Stephan Hacker@stephanhacker2.bsky.social · last mo.

What are the hot topics in Chemical Biology? If you want to learn about the exciting perspective of students of Johannes Morstein's (@morstein.bsky.social) Ch/Bi145 course at @caltech.edu, you can now do so in their ChemBioChem review. doi.org/10.1002/cbic... (1/13) @chemistryeurope.bsky.social

Chemical Biology 2025: Highlights From the Ch/Bi145 Course at Caltech

This student-authored review highlights notable advances in synthetically enabled chemical biology from 2025, spanning bioconjugation and bioorthogonal chemistry, visualization and sensing, precision...

doi.org