“Under the new model, investigators will submit a brief 40-page application each Friday explaining what they accomplished that week, what they propose to accomplish the following week, and why they still deserve to have a lab. Decisions will be emailed Sunday at 11:45 PM.”

In Preparation@inprep.bsky.social · last wk.

Frontier AI companies as biotech acquirers www.nature.com/articles/s41...

Now online in Cancer Discovery @aacrjournals.bsky.social: Molecular and Structural Basis of Pan-Resistance to BTK Degraders and Inhibitors doi.org/10.1158/2159...

My postdoctoral work! If you are interested in degraders/PROTACs, check it out!

Abdel-Wahab Lab, MSKCC@oawlab.bsky.social · 2w ago

Excited to announce a new paper out today in Cancer Discovery @aacrjournals.bsky.social on clinical mechanisms of resistance to BTK degraders. Led by @quinnsievers.bsky.social and part of our ongoing collaboration with Meghan Thompson, Nurix Therapeutics & Justin Taylor (U. Miami):

In case you missed this Cancer Discovery paper in the news last week: First-in-Human Testing of a Mutant KRAS Vaccine for Pancreatic Cancer Interception in High-Risk Cohorts - by Daniel Haldar, Amanda Huff, Michael Goggins, Elizabeth Jaffee, Neeha Zaidi, and colleagues @aacrjournals.bsky.social

American Association for Cancer Research (AACR)@theaacr.bsky.social · 3w ago

A vaccine to intercept pancreatic cancer in high-risk individuals was safe and elicited specific and durable immune responses, according to research published in the AACR journal Cancer Discovery. Learn more: www.aacr.org/about-the-aa...

Yesterday the US Administration supercharged its explicit effort to bar international students from staying in the US after graduation. All Americans should know: 1/3 of *all* STEM PhDs working in the US are immigrants who graduated from US universities, then stayed. www.piie.com/index%2Ephp/...

Left: Venus, 1 March 1982 Centre: Titan, 14 January 2005 Right: Boston, 15 July 2026

This radiating honeycomb is the glass skeleton of a diatom, captured via confocal microscopy from marine sediment off Namibia's coast. Invisible to the naked eye, diatoms & other phytoplankton produce 20%–50% of Earth's oxygen every year. 📷: Igor Siwanowicz, Janelia Research Campus.

Oooooo www.nature.com/articles/s41...

Metabolite glues as a means of purine sensing and chemotherapeutic response - Nature

Purines can act as endogenous molecular glues in human cells by anchoring a rate-limiting enzyme in purine biosynthesis to its inhibitor, and modifying this mechanism could provide a way to improve th...

nature.com

Day in the Lab: Dino Edition

We are all this scientist.

In Preparation@inprep.bsky.social · 3w ago

Holy COW. Text analysis of comments on the OMB rule: overwhelming opposition, overwhelmingly not form letters. (But 9 in 10 comments supporting the rule ARE form responses, LOL) Whatever happens next, folks have stepped up.

Karen R. Lips@karenrlips.bsky.social · 3w ago

techpolicy.press/the-public-r...

(1/2) Scientists from MSK and @weillcornell.bsky.social found that a small subset of T cells, called stem T cells, are responsible for making new T cells and continuously replenishing them in chronic disease.

Bone grows from the inside out, and this fluorescence micrograph of a developing mouse femur reveals the choreography underneath: osteoclasts (red) clear cartilage (purple) to make room for blood vessels (yellow), marrow, and new bone. 📸 Paul R. Odgren, @umasschan.bsky.social

Important statement from the New York Times

If Other Jobs Were Like US Senator www.theatlantic.com/newsletters/...

1/ This is a thread about America’s crumbling employer-based health insurance system. The percentage of working-age adults who get their health coverage from a job has declined from 67% in 1998 to about 60%. www.statnews.com/2026/07/07/s...

Tired of AI-generated figures? I asked our talented scientific illustrator Manon Zuurmond to draw some of the instruments and lab equipment we missed in NIH's otherwise fantastic BioArt resource. First batch now available as CC BY. Free for everyone to use in publications: github.com/Center-for-P...

New research from MSK investigates how a natural antifungal compound produced by helpful gut bacteria might help protect vulnerable patients; finds that a protein “fingerprint” in blood could predict dangerous clots in cancer patients; and more: https://bit.ly/4vzMuFj

Amy Bielawski is one of the 30 million people who run their own businesses. She's gone most of her life without health insurance. www.statnews.com/2026/07/07/a...

For a Georgia entrepreneur, health coverage has never been affordable

Amy Bielawski is one of the 30 million people who run their own businesses. She's gone most of her life without health insurance.

statnews.com

New preprint from the group, comparing CRISPRko and CRISPRi via a Perturb-seq readout: www.biorxiv.org/content/10.6...

Direct comparison of CRISPR knockout and interference with Perturb-seq

CRISPR knockout (CRISPRko) and CRISPR interference (CRISPRi) are two workhorse technologies for loss-of-function studies, yet direct comparisons between the two are scant relative to their widespread ...

biorxiv.org

“move from preprint to peer-reviewed publication leaves the central claims of most abstracts intact, indicating preprints are a reliable source…papers that were never posted as preprints were retracted at roughly twice the rate of those that were…” www.biorxiv.org/content/10.6...

Tracking claim changes from preprint to publication across 72,644 biomedical studies using large language models

Preprints now disseminate a large share of biomedical research before peer review. Because they have not yet passed peer review, some scientists regard preprint claims as unverified or potentially unr...

biorxiv.org

Our kind of fireworks: fruit fly neurons stacked in a rapid succession of rainbow colors. This video shows a small sampling of the more than 135,000 neurons in a typical fruit fly's brain, imaged by researchers at our Janelia Research Campus using multicolor flipout technique 🎆

Why do animals age in such similar ways, yet live for wildly different spans - from days to a century? Our new paper in @NatureAging fits a damage accumulation model across 9 species and finds the knob that best predicts lifespan doi.org/10.1038/s435...

A damage accumulation model identifies distinct aging regimes across species - Nature Aging

Raz and colleagues fit survival data across species to a stochastic model of damage accumulation and removal. They report that damage production rate best predicts lifespan and reveal two distinct agi...

doi.org