Bruno Castro
@brunommcastro.bsky.social
Senior Editor @NatureMaterials. Views are my own.
An ultrasound-scanning in vivo light source go.nature.com/3PZlNL4
An ultrasound-scanning in vivo light source - Nature Materials
A deep-tissue light source made from mechanoluminescent transducers stimulated by focused ultrasound enables wide imaging of live animal vasculature, and modulation of neuronal activity and behaviour.
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Our April issue is live! Featuring articles about cell viscosity of tumour cells, materials failure in active nematics, and stable facets in perovskite photovoltaics. We also feature a Perspective on antiferroelectrics and more. 👇 go.nature.com/4ctUzVt
Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung go.nature.com/4sbFlZZ
Amino acid-derived ionizable lipids enable inhaled base editing for therapeutic gene correction in the lung - Nature Materials
Gene correction in the lung is achieved with inhalable mRNA lipid nanoparticles containing an amino acid-derived ionizable lipid identified from screening and structure–function optimization studies.
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Mineral-originated bioelectronics for inhibition via lithium electrochemistry go.nature.com/4bDOCF6
Mineral-originated bioelectronics for inhibition via lithium electrochemistry - Nature Materials
A bioelectronic device incorporating triphylite (LiFePO4) as electrode is used for lithium-ion-specific inhibition of peripheral and central nervous system activities in rats and in mice.
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Mechanisms of active wetting and fluidification in epithelial cell collectives go.nature.com/3Pxjq1E
Mechanisms of active wetting and fluidification in epithelial cell collectives - Nature Materials
Active wetting and fluidification of breast cancer epithelia are shown to be controlled by IRSp53 and Afadin, cell adhesion proteins that regulate multicellular viscosity and tensile state during tumo...
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Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination go.nature.com/4bALQiO
Crosslinked ionizable lipids reprogram dendritic cell metabolism for potent mRNA vaccination - Nature Materials
Lipid nanoparticles incorporating a crosslinked ionizable lipid are shown to promote efficient endosomal escape of antigen mRNA and glycolysis stimulation in dendritic cells, to elicit robust vaccinat...
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Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization go.nature.com/4uGPjFk
Stress-relaxing granular bioprinting materials enable complex and uniform organoid self-organization - Nature Materials
A tunable granular biomaterial matrix is developed to support long-term bioprinting. Stress relaxation at high strains and long timescales is shown to be important for tissue self-organization in inte...
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Our March issue is now live! Featuring a Focus on heterogeneous materials and research on DNA origami, phase-changing materials, inflatable porous organic crystals and more. 👇 go.nature.com/3PkrkLC
In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy go.nature.com/4rYJYaE
In situ-generated vaccine-like pyroptosome for personalized cancer immunotherapy - Nature Materials
An injectable pH-sensitive nanoadjuvant is shown to induce effective pyroptosis of tumours, which, combined with the in situ photoactivable release of TLR agonists, generates a strong vaccine-like res...
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Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties go.nature.com/40aN673
Restoring the tumour mechanophenotype of vocal fold cancer reverts its malignant properties - Nature Materials
Vocal fold cancer tumours lose some of their malignant traits when mechanically stimulated by physiological stretch or vibrations, mimicking the opening and closing of vocal folds and phonation.
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Radioisotope-mimetic molecular afterglow probe for downregulated cancer biomarker imaging go.nature.com/472vrC2
Radioisotope-mimetic molecular afterglow probe for downregulated cancer biomarker imaging - Nature Materials
A probe with month-long molecular afterglow luminescence targeting a downregulated cancer biomarker detects small liver tumours for image-guided resection in mice and rabbits.
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Our February issue is live! Read about spin-locking of light, additives for perovskite-silicon tandem cells, and self-healing organic crystals. We also feature a Review on AI-driven approaches on materials discovery and much more. 👇 go.nature.com/4ahJxk5
Long-range chemical signalling in vivo is regulated by mechanical signals go.nature.com/49QSbFT
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
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Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells go.nature.com/4jZ8OUu
Cell viscosity influences haematogenous dissemination and metastatic extravasation of tumour cells - Nature Materials
The viscosity of tumour cells is shown to govern their ability to disseminate through the bloodstream and extravasate, establishing a key biomechanical factor of metastasis.
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Paper alert: Our study led by @evapillai.bsky.social and @sudimukherjee.bsky.social showing that mechanical properties of the #brain actively shape the molecular landscape during development and #axonpathfinding is finally out! www.nature.com/articles/s41... @pdncambridge.bsky.social @fau.de @MPZPM
Long-range chemical signalling in vivo is regulated by mechanical signals - Nature Materials
Tissue stiffness mediated by Piezo1 is shown to regulate the expression of diffusive guidance cues in the developing Xenopus laevis brain, revealing a crosstalk between mechanical signals and long-ran...
nature.com
Happy New Year! Our first issue of 2026 is now live. Read about frustrated magnetism in semiconductors, in-memory sensing in aqueous solutions, shear jamming in soft solids, tissue-specific delivery with LNPs and more. 👇 go.nature.com/44UabgW
2D semiconductor arrays for high-fidelity monitoring of neural activities. go.nature.com/3Ko32P1
Two-dimensional semiconductor-based active array for high-fidelity spatiotemporal monitoring of neural activities - Nature Materials
Two-dimensional molybdenum disulfide (MoS2)-based active arrays made by growing wafer-scale trilayer MoS2 directly on a polyimidine substrate achieve high-fidelity spatiotemporal neuronal monitoring i...
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Our last issue of 2025 issue is online! Featuring a Focus on scalable quantum photonics and articles on qubit quantum sensors, 2D polyamide for anode-free batteries, plasmonic printing of metal electronics, hermetic stretchable seals and more. See it below!👇 go.nature.com/48mFlP0
Nature Materials - Quantum photonics on a chip
Photonic technologies enable on-chip, scalable solutions for applications in quantum communications, quantum sensing and quantum computing.See Wang et al.
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We have observed a beautifully strange phenomenon of phase separation by human monocytes placed on soft matrix, which do it for survival. We model it by incorporating the Cahn–Hilliard equation with a Turing mechanism of local activation/global inhibition More here: www.nature.com/articles/s41...
Mechano-induced patterned domain formation by monocytes - Nature Materials
Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...
nature.com
Mechano-induced patterns of monocytes. go.nature.com/4hKDwPY
Mechano-induced patterned domain formation by monocytes - Nature Materials
Human primary monocytes reversibly phase separate into regular, multicellular, multilayered domains on soft matrices with physiological stiffness due to local activation and global inhibition processe...
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IL-12-releasing nanoparticles for ovarian cancer immunotherapy. go.nature.com/4oOPNVR
IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer - Nature Materials
Polymer-coated liposomes specifically target and deliver interleukin-12 to metastatic ovarian cancer, strongly sensitizing the tumours to combination therapy with immune checkpoint inhibitors.
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Ultrasound mechanogenetics for CAR T therapy. go.nature.com/43Tvpeb
Tumour priming by ultrasound mechanogenetics for CAR T therapy - Nature Materials
A focused-ultrasound-mediated mechanogenetics approach enables the genetic modification of cancer cells near solid tumours to activate chimeric antigen receptor T cell response and achieve tumour supp...
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Our November 2025 issue is online! Featuring a Focus on PEG alternatives for RNA therapeutics and pieces on halide electrolytes for all-solid-state batteries, reprogrammable morphogenesis in free-standing 3D structures and more. Read it below.👇 go.nature.com/3WE9ALM
IL-12-releasing nanoparticles for effective immunotherapy of metastatic ovarian cancer @natmater.nature.com www.nature.com/articles/s41...
Amazing to have our work finally out!!! 😍🤩😍
Sara Wickstrom@sarawickstrom.bsky.social · 12mo agoHow do #stemcells integrate information to coordinate fate decisions? Delighted to finally see our work showing how growth factors regulate the mechano-osmotic state of the #nucleus and #chromatin to control #pluripotency exit out! www.nature.com/articles/s41... see 🧵 👇
Join us for the first @embo.org meeting on Intracellular mechanics and organelle mechanobiology! Registrations are open, submit your abstract by November 14: we have plenty of slots for short talks! #EMBOMechanobio
Felix Campelo@felixmendu.bsky.social · last yr.Announcing a new @embo.org Workshop on "Intracellular mechanics and organelle mechanobiology" that we are organizing with Michael Krieg and Verena Ruprecht at @icfo.eu (Barcelona) on 16-20 February, 2026. Please, repost and spread the word! 🙏 #EMBOmechanobio meetings.embo.org/event/26-org...
Join the team! We’re seeking for an Associate or Senior Editor with a research background in the fields of energy materials or catalysis. Deadline: October the 13th. Apply here 👇 springernature.wd3.myworkdayjobs.com/en-US/Spring... @natureportfolio.nature.com
Associate or Senior Editor, Nature Materials
Title: Associate or Senior Editor, Nature Materials Organization: Nature Portfolio Locations: New York, Jersey City, Shanghai or Beijing Application Deadline: October 13th, 2025 About Springer Nature ...
springernature.wd3.myworkdayjobs.com
🚨Join us! We're soon opening 3 postdoctoral positions in #AIDrivenBiology. Seeking biologists (especially microbiology and infection biology), computer scientists, and microscopy developers. Ideal candidates are those eager to use or develop next-gen tech for cell biology. Get in touch (DM/email)
The phase II clinical trial in China tested CAR T cells in people with advanced gastric cancer or gastro-oesophageal junction cancer - one of the first times this therapy has worked against solid tumours 🧪 #MedSky www.nature.com/articles/d41...
Cancer-fighting CAR T cells show promising results for hard-to-treat tumours
Trial in China is one of the first times the immune therapy has worked against solid tumours.
nature.com
A single dose of commercial CAR-T therapy costs around $500,000. So a great deal of work is going into in vivo treatments - engineering T cells inside the body- that might cost an order of magnitude less. Fascinating! 🧪 @nature.com www.nature.com/articles/d41...
Cancer-fighting immune cells could soon be engineered inside our bodies
Manufacturing CAR T cells in the laboratory is expensive and time-consuming. An in vivo approach could get the powerful therapy to more people.
nature.com
