The latest from @felixmendu.bsky.social lab! cool imaging, mechanobiology and Golgi:-)
Journal of Cell Biology@jcb.org · 2d agoMechanical forces stimulate #Golgi export. New study from Chandini Bhaskar Naidu, Javier Vera Lillo, Jean-Baptiste Manneville @upcite.bsky.social, Stéphanie Miserey @institutcurie.bsky.social, Felix Campelo @felixmendu.bsky.social @bist.eu and colleagues: rupress.org/jcb/article/... #Membrane
Job alert! I'm recruiting a new post-doc to work on mechanisms of co-translational quality control in the ER. Looking for expertise in ribosome biology and yeast genetics/cell biology. Please reach out to me with any questions. www.dundee.ac.uk/work-for-us/...
Postdoctoral Research Assistant - UOD2336
Closing date: Thursday 27 August 2026, 23:59
dundee.ac.uk
Mechanobiology of organelles beyond the nucleus... I LOVE where this is taking the field. By @felixmendu.bsky.social lab We saw glimpses of such exciting findings prepub in talks at the ASCB-EMBO in San Diego back in 2024. I'm bracing my brain for what's coming in the next 2,3,5 years 🌀
Felix Campelo@felixmendu.bsky.social · last wk.Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...
Very happy to see this #MechanoGolgi story out (and in full open access, thanks to @upf.edu). Thanks a lot to everyone who contributed and helped make this possible, and, hopefully, more to come! rupress.org/jcb/article/...
Mechanical forces stimulate Golgi export
Bhaskar Naidu and Vera Lillo et al. show that extracellular mechanical forces reciprocally regulate Golgi function. By linking cell adhesion and spreading,
rupress.org
Felix Campelo@felixmendu.bsky.social · 11mo ago🧵 I've been meaning to write a #Skytorial on our recently posted prepring in which we show evidence that the Golgi 🥞 is a mechanoresponsive organelle. Extracellular mechanical forces also tune Golgi export capacity! 👉 www.biorxiv.org/content/10.1...
Bhaskar Naidu, Vera Lillo, Manneville, Miserey, @felixmendu.bsky.social et al. show that extracellular mechanical forces reciprocally regulate #Golgi function. The study reveals a feedback pathway by which Golgi export supports cell spreading and mechanoadaptation. rupress.org/jcb/article/...
Sign up now for the EMBO Workshop "Organelle dynamics in health and disease: Bridging molecules to organisms" in #Edinburgh, United Kingdom, 12–14 October 2026. Deadline: 15 July 2026 https://meetings.embo.org/event/26-organelle-dynamics #EMBOOrganelleDynamics #LifeSciences #meeting #EMBOevents 🧪
1/4 Thrilled to share our new paper on the role of ER-export in multiple myeloma (MM) published in @sigtrans-sttt.bsky.social www.nature.com/articles/s41... Thanks to editors and reviewers for a constructive process. Here is a thread to summarize the major findings #ER_literature #MultipleMyeloma
Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma - Signal Transduction and Targeted Therapy
Signal Transduction and Targeted Therapy - Targeting endoplasmic reticulum export disrupts metabolic resilience in multiple myeloma
nature.com
My department @eth-dbiol.bsky.social at ETH Zurich is hiring for a tenured professor in mol cell bio and biochemistry (associate/full). The position is within the Institute of Biochemistry (www.bc.biol.ethz.ch) and it is fairly open within their scope of research. www.nature.com/naturecareer...
Professor of Molecular Cell Biology and Biochemistry - Zurich, Switzerland job with ETH Zurich | 12861386
The Department of Biology at ETH Zurich invites applications for the above-mentioned tenured professorship at the Institute of Biochemistry
nature.com
Exciting preprint from @hessofarhan.bsky.social! Mechanical stress has a new sensor! IRE1 detects ER membrane tension and drives protein synthesis independently of its canonical UPR role, reshaping cell and organelle mechanobiology. www.researchsquare.com/article/rs-1...
Mechanosensing at the endoplasmic reticulum by IRE1
Sensing and integration of mechanical forces in eukaryotic cells have largely been attributed to the plasma membrane and the nucleus. Here, we identify the endoplasmic reticulum (ER) as an autonomous ...
researchsquare.com
WORK: our Bionanoscience department at TU Delft is looking to hire an Assistant Professor in Biophysics of Living Systems. Apply! Deadline 30 July careers.tudelft.nl/job/Delft-As... RT=nice
Assistant Professor in Biophysics of Living Systems
Assistant Professor in Biophysics of Living Systems
careers.tudelft.nl
The extent of the IF obsession is evident from any and every Google search for a journal - even venues that don't warrant one. This literally makes or breaks journals - non-profits are hit particularly hard - and it stifles innovation and distorts science. 2/2
Hi #membrane folks! This is today, last talks to close this academic year's trafficking seminar season :) 👇
Ishier Raote@ishier.bsky.social · 2mo agoMembrane Trafficking Seminar series returns with two talks on how membranes organise, move, and shape cellular life. Final session until September! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of cell biology at its best. felixcampelo.wixsite.com/membranetraf...
From Segmentation to Pipelines: AI-Assisted Bioimage Analysis with Python 21-24 September 2026, Erasmus MC Rotterdam (The Netherlands) Application deadline: 25 July 2026 More information & signing up: courses.microscopie.nl?event_id=527
NL-BioImaging Advanced Image Analysis for Biologists 2026
courses.microscopie.nl
Membrane Trafficking Seminar series returns with two talks on how membranes organise, move, and shape cellular life. Final session until September! Join @felixmendu.bsky.social @franbottanelli.bsky.social and me for an afternoon of cell biology at its best. felixcampelo.wixsite.com/membranetraf...
”Overall, the group’s trajectory is considered very good with respect to its scientific contributions, even he should diversify more the journals where he publishes his studies and not focus in @elife.bsky.social, a journal with a peculiar evaluation process in which he is senior editor.” 😭🙈
Man's expressive 'Ok Okay' reaction
ALT: Man's expressive 'Ok Okay' reaction
static.klipy.com
The endolysosomal system in conventional and unconventional protein #secretion. A Perspective by Eloïse Néel, Marioara Chiritoiu-Butnaru, Julien Villeneuve and colleagues: rupress.org/jcb/article/... 📕 Part of #Lysosomes 2026: rupress.org/jcb/collecti...
If you like podcasts about math and science, I hope you'll check out The Joy of Why, which I cohost with my pal @jannalevinastro.bsky.social. Our first guest is the wonderful Jennifer Doudna, who discusses RNA, the CRISPR gene-editing mechanism, and her rebellious streak. youtu.be/T1SzNRElup0?...
What Is the Future of Gene Editing? | PODCAST: The Joy of Why
YouTube video by Quanta Magazine
youtu.be
Procollagen 1 assembles into phase-separated condensates in the endoplasmic reticulum rupress.org/jcb/article/...
Procollagen 1 assembles into phase-separated condensates in the endoplasmic reticulum
In contrast to prevailing dogma, we report that procollagen 1 assembles into a liquid condensate within cells, resolving the long-standing problem of how c
rupress.org
Thermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...
thermofisher.com
Reese Richardson@reeserichardson.bsky.social · 2mo agoThe Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)
Holy smoke--Thermo Fiasher stonewalling after being caught re-handed. How does copying and pasting bands fit into optimized for presentation and clarity???
Reese Richardson@reeserichardson.bsky.social · 2mo agoThermo Fisher now has a page up in response to our observations. They flatly deny that images were manipulated or fabricated while repeating that images were "optimized for presentation and clarity on the website", no lie, six times. www.thermofisher.com/us/en/home/l...
How do cells control formation of Golgi stacks upon demand? Roman Polishchuk, Franck Perez and collaborators identify a ‘Golgi regulon’ under control of the CREB3L1 transcription factor link.springer.com/article/10.1...
A coordinated transcriptional program controls de novo Golgi biogenesis - The EMBO Journal
The Golgi apparatus expands during differentiation and increased secretory demand, yet the transcriptional mechanisms governing its biogenesis remain poorly defined. To investigate this process, we de...
link.springer.com
ICYMI: New Online! Caveolae mechanics in cellular functions and disease
Caveolae mechanics in cellular functions and disease
Nature Reviews Molecular Cell Biology, Published online: 02 June 2026; doi:10.1038/s41580-026-00964-2Caveolae are membrane invaginations that facilitate cell signalling and act as membrane reservoirs. This Review discusses recent insights into caveolae assembly and disassembly, their roles in mechanotransduction and how impaired caveolae mechanics contribute to human disease.
dlvr.it
We are so ready! Remember, this afternoon and tomorrow morning we will be at the @prbb.org Auditorium. Come and enjoy bioscience!
Apply here! meetings.embo.org/event/26-pro...
Advances and new frontiers in protein translocation across membranes
The organization of cells into membrane-bound compartments is fundamental to life, requiring proteins to cross these barriers through highly specialized translocation systems. Understanding these pro…
meetings.embo.org
Ian Collinson@ianofbristol.bsky.social · 2mo agoProtein Traffickers Deadline for @embo.org workshop abstract submission now extended-19th June. Spaces for short talks available Grants available for childcare and accessibility needs @biologists.bsky.social travel bursaries for students and early career scientists. Apply now and repost
Wu and Hegde annotate and analyze the topology of 4,863 human endoplasmic reticulum–inserted membrane proteins and their 20,546 transmembrane domains, showing that transmembrane domains inserted by different pathways can tolerate different biophysical properties. rupress.org/jcb/article/...
How to determine the proteome of cellular compartments? We established a method to do just that, published n @eLife.bsky.social: SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection doi.org/10.7554/eLif...
SPEx: Compartment-Resolved Proteomics via Expansion Microscopy–Guided Microdissection
doi.org
If you are want to know how pioneer axons reach new born hair cells, check this new preprint from the lab identifying the chemokine Cxcl14 as a new guidance cue. A wonderful work led by Mireia Rumbo, @mireiarumbo.bluesky.social doi.org/10.64898/202... doi.org/10.64898/202...
doi.org
Happy to announce that the 2027 EMBO Cell Polarity and Membrane Dynamics workshop will be a reality! Big thanks to @embo.org for funding it and of course to Alex @alexludwig.bsky.social and Diana @dianapinheiro.bsky.social, it'll be fun :) Stay tuned and save the dates! coming-soon.embo.org/w27-32
Cell polarity and membrane dynamics
16–21 May 2027 | Sant Feliu de Guíxols (Girona), Spain
coming-soon.embo.org
@sholtodavid.bsky.social Have you seen this WB from ThermoFisher? Still anti-p53 antibody, but another clone (MA-12648 instead MA5-12557). It also looks like that the band in lane 3 was rotated and reused in lane 4. Moreover, it seems that same band was used for the 2 different clones.
After so many #notthecover one of @probablycarmen.bsky.social of a CAR T cell engaging with a cancer cell made it to the front of @embojournal.org! Want to know more about the function of protrusions in early #Tcell activation? Check out how we became accidental immunologists!
The EMBO Journal@embojournal.org · 3mo agoIn issue 10: Convergent evolution of aerobic fermentation CIN promotes migration & invasion via EFEMP1 secretion SenSet resource defines cell-type specific senescence signatures ... Cover: @franbottanelli.bsky.social and colleagues link.springer.com/journal/4431...
