Ruth Napier & Lab 🤘

@ruthjeannapier.bsky.social

🧪Born to science ♾️ 🧫Microbiologist turned immunologist 🦠Environment+🧬genetics=autoimmunity #NOD2 #CARD9 #blausyndrome #axSpA #fungi #IL17A #IL17F #Mtb

I'm so excited to share our new paper in Cell where we provided T cells two genes that allow metabolism of a safe form of glucose (derived from cellulose). This fuel allows human CAR-T cells to fight tumors better! Congrats go to Matt Miller, now a postdoc at Salk. www.cell.com/cell/fulltex...

Fungal-derived cellobiose metabolic pathway fuels T cells to bypass intratumoral glucose competition

Equipping T cells with fungal enzymes to utilize cellobiose (a safe and natural disaccharide of glucose obtained from the wood polymer cellulose) enhances their viability and effector function in tumo...

cell.com