New Member Alert: @angelasteinauer.bsky.social from École Polytechnique Fédérale de Lausanne joined SBGrid in August. Welcome!!

Technical Notes: XDS licensing change XDS is now licensed through DECTRIS & will remain freely available for nonprofit users w/ the added bonus that time-bound version limitations no longer apply. The first release from DECTRIS is out (see software changes below for details). #SBGrid #Updates

SBGrid's eLife paper received a citation in August from Andrew Kruse from @harvardmed.bsky.social in @pnas.org : Activation of the angiotensin II type I receptor by a nonpeptide agonist. Read more here: buff.ly/BQo4Arj #SBGrid #StayConnected

Activation of the angiotensin II type I receptor by a nonpeptide agonist | PNAS

The angiotensin II type I receptor (AT1R) is a G protein–coupled receptor that regulates the cardiovascular system and as a result is one of the mo...

pnas.org

Technical Notes: macOS 27 expected this fall Apple is expected to release macOS 27 in the fall, & as w/ many new operating system releases, we recommend that users delay updating until the bugs are worked out. Contact us at bugs@sbgrid.org to report any problems you encounter. #SBGrid #Updates

New Member Alert: Stephen Ragsdale from @umich.edu Medical School joined SBGrid in August. Welcome!!

SBGrid's eLife paper received a citation in August from Eric Fischer from @danafarber.bsky.social in @nature.com DCAF11-dependent molecular glue degrader activated by glutathionylation. Read more here: buff.ly/q63j29D #SBGrid #ScienceMatters

SBGrid's eLife paper received a citation in August from Peter Dahlberg at Stanford University in @pubs.acs.org Nano: Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes. Read more here: buff.ly/XPuZ85a #SBGrid

Cryo-Electron Tomography Reveals Nanoscale Thick Filament Disorganization in MYH7 P710R Hypertrophic Cardiomyopathy Cardiomyocytes

Abstract. Hypertrophic cardiomyopathy (HCM) is the most common monogenic inherited heart disease and is a major cause of sudden death in individuals under

pubs.acs.org

Community Announcement: Upcoming events from our partners at @instruct-eric.bsky.social Instruct-ERIC Industry Webinar - Mass Photometry to support Structural Biology Research October 13, 2026 | Virtual Presented in collaboration with Refeyn Register here: buff.ly/HP2YvTE #SBGrid #Collab

Instruct-ERIC Industry Webinar - Mass Photometry to support Structural Biology Research - In Collaboration with Refeyn

<p> </p> <p>On Tuesday 13 October Instruct-ERIC are hosting a webinar in collaboration with Refeyn, to discuss Mass Photometry and how it can benefit your research.</p> <p> </p> <p style="text-align:…

instruct-eric.org

Fisk University student Cariuna Ellison's highlight features a @pnas.org paper from Kate Ferguson's lab at @yale.edu School of Medicine. Ferguson's group identifies the activation mechanisms of an important protein receptor, EGFR, linked to cancer. Read more here: buff.ly/iCcj7Wu #SBGrid #Protein

Brake-ing Down Protein Activation and Signaling

This publication highlight is part of the SBGrid Communities Project focused on science education and demonstrating how structural biology…

medium.com

New Title Alert: OCTOPI- is a deep-learning framework for automated 3D particle picking in cryo-electron tomography, with tools for training and running 3D U-Net models and automatically exploring model configurations. More here: buff.ly/WXgAVEN #SBGrid #Software

GitHub - Biohub/octopi: Search for Protein 3D Coordinates in CryoET Tomograms

Search for Protein 3D Coordinates in CryoET Tomograms - Biohub/octopi

github.com

Antibodies guiding cancer immunotherapy: a publication in @cp-cancercell.bsky.social w/ contributions from Priyamvada Acharya & colleagues from @dukemedschool.bsky.social. Read more here: buff.ly/CrOio1I #SBGrid #Cancer #Antibody

Antibodies guiding cancer immunotherapy

SBGrid member Priyamvada Acharya contributes to exploring how antibodies produced by tumor-infiltrating plasma cells could guide therapies.

medium.com

Community Announcement: Upcoming events from our partners at @instruct-eric.bsky.social Instruct-ERIC Webinar Series: Structure Meets Function 49 September 15, 2026 | Virtual Register here: buff.ly/F3iUBMc #SBGrid #Collab

Instruct-ERIC Webinar Series: Structure Meets Function 49

<p>The latest webinar in the Instruct-ERIC Structure Meets Function series this month includes speakers who have accessed cutting-edge structural biology services through Instruct. The webinar series…

instruct-eric.org

The not so easy job of protecting our DNA: a publication in @natsmb.nature.com from the lab of Nikola Pavletich at @mskcancercenter.bsky.social in which researchers describe the structure of ATR-ATRIP complex bound to its two activators. Read more here: buff.ly/S5IWOVw #SBGrid #DNARepair

The not so easy job of protecting our DNA

SBGrid member Nikola Pavletich reports on the structure of ATR-ATRIP complex bound to two activators, revealing key DNA-damage checkpoints.

medium.com

August's software push includes - AlphaFold3, AlphaPulldown, AmberTools, CCP4, Chromap, COOT, cryoDRGN, DIALS, Foldtree, ICM Browser, NMRFx-Anaylst, OpenFold3, Open Force Field Toolkit, OpenMM, pyCoAn, pytom-match-pick, RDKit, Scipion, Schrödinger, Warp, and XDS. More here: buff.ly/wN9LYyJ #SBGrid

SBGrid Consortium - Software Updates

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

sbgrid.org

Community Announcement: Instruct.SI CryoEM Workshop 2026, Single Particle Analysis 11/10-11/12, 2026 | National Institute of Chemistry, Ljubljana, Slovenia Register here: buff.ly/cdTUjrU

New Event Alert: The SBGrid CryoEM Cloud Tournament! Teams worldwide will analyze the same confidential, unpublished CryoEM dataset in a preconfigured AWS cloud environment, competing to deliver the most accurate, efficient, & scientifically useful results. More here: buff.ly/LvTjHbb #SBGrid #AWS

SBGrid Consortium - News and Events - Call to Participate: SBGrid CryoEM Cloud Tournament

The SBGrid Consortium is an innovative global research computing group operated out of Harvard Medical School. SBGrid provides the global structural biology community with support for research…

sbgrid.org

New Member Alert: In August, @yoonseokkim.bsky.social from École Polytechnique Fédérale de Lausanne joined SBGrid. Welcome!!

Our software webinar series will resume in October with Beata Turoňová, Group Leader at the @mpibp.bsky.social, introducing cryoCAT. Until then, you can catch up on webinars you missed from our last series on the SBGrid YouTube channel. More here: buff.ly/p1w3J7S #SBGrid #Webinars

SBGrid Consortium

For structural biologists, by structural biologists! The SBGrid TV channel was developed with participation from many members of the structural biology community. We welcome suggestions for topics to…

youtube.com

Our August Tale features Prof. Mihnea Bostina, who reflects on his scientific transit across the globe & finally making his home in New Zealand. From his laboratory at the @universityofotago.bsky.social. Read more here: buff.ly/Af3qVLc #SBGridTales #StayConnected

Viruses for Good

Mihnea Bostina works from his New Zealand lab at University of Otago to harness the therapeutic potential lurking in viruses.

medium.com

New Member Alert: Taha Shahid from the @unibirmingham.bsky.social joined SBGrid in July. Welcome!!

SBGrid's eLife paper received a citation in July from frank sicheri from @utoronto.ca in @natcomms.nature.com: Structure and mechanism of inhibition of lysine demethylase 2A (KDM2A) by compound 183c. Read more here: buff.ly/7caT1d5 #SBGrid #StayConnected

SBGrid's eLife paper received a citation in July from karin reinisch from of @yaleschoolofmed.bsky.social in @cp-molcell.bsky.social: Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin. Read more here: buff.ly/T0eFlS3 #SBGrid #ScienceMatters

Cryo-EM structure of soluble VPS13C suggests its regulation by a conformational switch and by calmodulin

VPS13C, whose dysfunction causes Parkinson’s disease, adopts a lipid-transfer-inactive conformation in the cytoplasm and relies on calmodulin for proper folding and localization to membrane surfaces.

cell.com

New Title Alert: Hax- is a package that includes several tools to study conformational heterogeneity from CryoEM data. More here: buff.ly/u9NPogU #SBGrid #Software #StructuralBiology

SBGrid's eLife paper received a citation in July from Pedro Pereira from Universidade do Porto in Protein Science: A cryptic aromatic binding pocket in the highly thermostable GpgS from Mycobacterium hassiacum hints at MGLP pathway crosstalk. Read more here: buff.ly/oJ6bpFN #SBGrid #StayConnected

A cryptic aromatic binding pocket in the highly thermostable <fc>GpgS</fc> from <fi>Mycobacterium hassiacum</fi> hints at <fc>MGLP</fc> pathway crosstalk

Mycobacteria have long posed a threat to human health, being responsible for a range of hard-to-treat infections such as tuberculosis, leprosy, and other chronic diseases caused by nontuberculous…

onlinelibrary.wiley.com

New Member Alert: In July, Lisa Olshansky from University of Illinois at Urbana-Champaign joined SBGrid. Welcome!!

SBGrid's eLife paper received a citation in July from @palencialab.bsky.social from @ugrenoblealpes.bsky.social in @jacs.acspublications.org. Read more here: buff.ly/HgcuBEZ #SBGrid #StayConnected

Alternative Splicing of a Structured Partner Alters the Folding-Upon-Binding Trajectory of an Intrinsically Disordered Protein

Abstract. Folding-upon-binding of intrinsically disordered proteins (IDPs) is governed by a complex interplay of kinetic and thermodynamic factors shaped b

pubs.acs.org

Community Announcement: Mass Photometry to support Structural Biology Research 10/13/26 | Virtual Join to learn about how to access Mass Photometry technologies through Instruct-ERIC and hear from scientists who have used Mass Photometry in their research. Register here: buff.ly/0c3VcSn

Instruct-ERIC Industry Webinar - Mass Photometry to support Structural Biology Research - In Collaboration with Refeyn

<p> </p> <p>On Tuesday 13 October Instruct-ERIC are hosting a webinar in collaboration with Refeyn, to discuss Mass Photometry and how it can benefit your research.</p> <p> </p> <p style="text-align:…

instruct-eric.org

New Title Alert: DisVis- is a Python package and command line tool to visualize and quantify the accessible interaction space of distance restrained binary biomolecular complexes. More here: buff.ly/3AlzIzu hashtag#SBGrid hashtag#Software hashtag#StructuralBiology

New Member Alert: Arthur Neuberger from @lmu.de joined SBGrid in July. Welcome!!

SBGrid's eLife paper received a citation in July from Aravindan Ilangovan from @qmul.bsky.social in @narjournal.bsky.social: Bacillus subtilis DnaB forms multiple protein–protein interactions essential for DNA replication initiation. Read more here: buff.ly/MhY7yFn #SBGrid

Bacillus subtilis DnaB forms multiple protein–protein interactions essential for DNA replication initiation

Abstract. DNA replication is initiated at specific chromosomal loci termed origins. In bacteria, the master replication initiation protein DnaA unwinds the

academic.oup.com