Researchers found that Qβ bacteriophage nanoparticles functioned as an adjuvant capable of eliciting long-term memory. These data support the use of bacteriophage-derived nanoparticles for conjugate vaccines against antibiotic-resistant bacteria. 🔗 https://ow.ly/gGxF51035Jp

Data identifies circNav1 as a conserved circRNA of murine macrophages that fine-tunes inflammatory gene expression by coupling HuR-dependent Cebpb mRNA stabilization to selective IL-6 transcription. Learn more: https://ow.ly/ayQw51035CE.

New data show that IFN-α subtypes can stimulate unique responses and distinctly modulate both CD4 and CD8 T cells contributing to the growing body of evidence that IFN-α subtypes are not functionally redundant. Learn more: https://ow.ly/vfqK51035z2.

November is #NationalDiabetesAwarenessMonth! The Journal of Immunology invites submissions for our collection: Immunology of Diabetes, guest-edited by Barbara Nikolajczyk & Mary Markiwicz. Submit original research on immune mechanisms in diabetes by Dec 31, 2027. 🔗 https://ow.ly/nyWC51033m3

Eager to get published fast? Don't fall for flashy email bait! Early-career researchers can easily slip into predatory publishing traps. AAI shares key tips to protect your hard-earned research: https://ow.ly/jaie51032qp. #PhDLife #PostdocLife #AcademicTwitter

Data show the importance of macrophage high mobility group (HMG) nucleosome-binding proteins in maintaining tissue-specific gene expression and supporting inflammatory responses, providing clues to the phenotype of macrophages following alarmin secretion. https://ow.ly/AQXy5101t6y.

Early prostaglandin D2 (PGD2) production is associated with resistance to F. tularensis and B. pertussis in obese mice, suggesting PGD2 signaling may contribute to obesity-associated protection, helping identify novel host-directed therapeutic strategies https://ow.ly/pxgB5101t5Z.

Many peptide antigens are prone to form oxidation products. Researchers found oxidation resistant (OXR) antigens provide a strategy for eliminating sulfur oxidation products and improving the manufacturability and shelf-life of peptide-based vaccines. https://ow.ly/KhHF5101t32.

Data show that T cell receptor-directed nanobodies with Vβ-restricted specificity enable cellular detection, inhibition of antigen-driven T cell activation, and immuno-PET/CT imaging of defined T cell populations in vivo. Learn how in The JI: https://ow.ly/He4u5101t06.

Researchers develop a simple and effective gavage-fomite based method to generating “mice with natural microbiota.” Data supports broader use of these models in basic and translational immunological research across the field. Learn more: https://ow.ly/ejss5101sWL.

Data establish the first allele-specific peptide-binding motif framework for canine MHC class II, providing a foundation for DLA-allele–informed CD4+ T-cell epitope discovery studies and antigen specific immune response characterization in dogs. https://ow.ly/7NS15101sQV.

Researchers investigated the impact of TET2-driven clonal hematopoiesis of indeterminate potential on inflammatory bone loss and identified inflammatory bone loss associated with increased tissue infiltration of neutrophils, monocytes, and Th17cells. https://ow.ly/4Ppe5101sKu.

Data reveal a previously unrecognized pathway in which the IL-33/ST2/SOCS1 axis suppresses NLRP3 expression to facilitate parasitic persistence during visceral leishmaniasis. Targeting this pathway is an opportunity for new therapeutics: https://ow.ly/HhCa5101sAJ.

Researchers identify Arid2 as a key regulator of peripheral B cell maturation and show that losing it produces stage-specific molecular and functional consequences that become more pronounced during hematopoietic reconstitution. Read more in The JI: https://ow.ly/rEUe50ZZ2GH.

A pilot clinical trial demonstrated that intravenous scopolamine, a muscarinic receptor antagonist, significantly improved #psoriasis by antagonizing elevated acetylcholine and blocking M1 receptor-mediated IL-23 release in dendritic cells. Learn more: https://ow.ly/SyHM50ZZ2AA.

Data suggest that papaverine, an alkaloid, improves symptoms of #psoriasis through inhibition of proinflammatory cytokines and suppression of aberrant plasma cell differentiation, demonstrating its therapeutic potential. Learn more in The JI: https://ow.ly/KqX750ZZ2zm.

Data indicate that selenium is a promising immunomodulator adjunct that augments CD8+ T cell function and improves the response to anti-PD-1 therapy, suggesting it could be combined with immune checkpoint inhibitors for cancer treatment. Learn more: https://ow.ly/gtmE50ZZ296.

Sublethal whole body irradiation impairs the kinetics, subset composition, and function of memory CD4 T cells, compromising their ability to mount effective recall responses to clear the infection, affecting patients with a history of radiation exposure. https://ow.ly/rHA250ZZ1VW.

Data show that small extracellular vesicles produced after hepatic liver-ischemia-reperfusion reach the spleen and are acquired by immune cells, providing a mechanism by which localized hepatic injury can affect immune signals beyond the liver. Read more: https://ow.ly/C6a750ZZ08o.

Researchers identified a previously unrecognized neutrophil-dependent skin-kidney axis in which acute UV injury to the skin elicits renal vascular and tissue remodeling programs, which could inform our understanding of #lupus nephritis. Read more: https://ow.ly/vHFm50ZZ06v.

Data reveal an unknown mechanism by which PD-L1 suppresses T-cell immunity in Nile tilapia through modulation of lipid metabolism, highlighting the essential role of metabolism regulation in immune checkpoint signaling and new evolutionary insights: https://ow.ly/mMMP50ZUWUs.

Data identify CD55 as a marker of a distinct CD4+ T cell subset with altered functional and molecular characteristics and support its potential utility in the early diagnosis and differential diagnosis of rheumatoid arthritis. Read more: https://ow.ly/TRwG50ZUWRx.

Researchers provide proof-of-concept data that microbeads with a anti-CD28 monoclonal antibody may induce a combination of direct toxicity and enhanced anticancer immunity, leading to efficient treatment of metastatic disease. Find out more in The JI: https://ow.ly/Pih950ZUWNQ.

Unique transcriptional and epigenetic programs of IgM, IgG, and IgA antibody-secreting cells (ASC) suggest that each ASC is a distinct lineage that dictates specific functional characteristics important for humoral immunity. Learn more: https://ow.ly/MHoZ50ZUWK2.

Researchers developed an MHC-II tetramer to identify TcdB-specific CD4+ T cells via flow cytometry when studying Clostridioides difficile generating a new tool for future studies of toxin-specific CD4+ T cell responses. Read more in The JI: https://ow.ly/nN2z50ZUWr7.

When trying to study the impact of sex differences on immune responses, data showed that FCG male mice (XXM and XYM) do not mount appropriate immune responses to a respiratory virus infection due to the translocation of Sry to chromosome 3. Read more: https://ow.ly/v8hA50ZUWkN.

New data indicate that micro-RNA-221-5p exacerbates septic cardiomyopathy by negatively regulating neuropilin-1 (NRP1), suggesting that this pathway could represent a novel therapeutic strategy for sepsis-related heart complications. Learn more in The JI: https://ow.ly/xqVz50ZUW5B.

Data provide new insights into a subpopulation of invariant natural killer T (iNKT) cells and demonstrates that the Fgd5 reporter mouse model can be used as a powerful tool to study iNKT cell biology. Find more in The JI: https://ow.ly/ZsgJ50ZUUMp.

Data show that antibodies and bispecific killer engagers (BiKEs) that are neutralizing and target FcγRs decrease viremia and weight loss in the SARS-CoV-2–infected K18-hACE2 mouse model, helping inform new therapeutics. Read more: https://ow.ly/8PhG50ZUUIr.

Researchers inactivated the Ii genes in two well-characterized human B cell lines and assessed the effect on MHCII antigen presentation and other Ii- and MHCII-dependent B cell properties. Read what they found in The JI: https://ow.ly/ZNfG50ZUUgY.