Excited to share our paper looking at the downstream benefits of amyloid clearance in a patient treated with Amyloid Targeting Therapy is now available! @jama.com @patch-lab-upenn.bsky.social

JAMA Neurology@jamaneurology.com · last mo.

Presented at #AAIC26 from @JAMA.com: #Amyloid clearance was most efficient in gyral crests, not sulcal depths, and correlated locally with reduced #tau #pathology and #neurodegeneration after aducanumab therapy in #AlzheimerDisease. ja.ma/3SYsxtZ

Here are the AAIC26 poster presentations scheduled for the PATCH Lab, stop by to hear about all the cool work we’ve been up to! #AAIC26 @cb-neuro.bsky.social @xueyinglyu.bsky.social @amandadenning.bsky.social @kjobson.bsky.social @khodakarami.bsky.social

Looking forward to AAIC26 in London! Stop by these PATCH Lab talks catch up on exciting new work in the lab. #AAIC26 @cb-neuro.bsky.social @pulks-kh.bsky.social @alzassociation.bsky.social

Congratulations to Dr. Xueying Lyu on her successful PhD Thesis Defense in the Department of Bioengineering! Thank you to Drs. Sandhitsu Das and David Wolk for their support. So proud of you, Dr. Lyu! @xueyinglyu.bsky.social

Our new paper showing agreement between PET and plasma-based temporal models of Amyloid and Tau in Alzheimer's is up online: onlinelibrary.wiley.com/doi/10.1002/.... Thanks to all those in @patch-lab-upenn.bsky.social and Penn ADRC who made this work happen!

Temporal Modeling of Amyloid and Tau Trajectories in Alzheimer's Disease Using PET and Plasma Biomarkers

Objective This study aimed to compare positron emission tomography (PET) and plasma-based temporal modeling of amyloid and tau biomarkers in Alzheimer's disease. Methods Longitudinal amyloid PET (...

onlinelibrary.wiley.com

Excited to share our new publication! Thanks to all those from @patch-lab-upenn.bsky.social, Penn ADRC, and others that made this work happen!

JAMA Neurology@jamaneurology.com · 8mo ago

Individuals with #AlzheimerDisease showing greater clinical impairment than predicted by tau burden are more likely to have copathology, including #TDP43 and #AlphaSynuclein, and experience faster decline. ja.ma/3KLq5Du

Thank you to everyone from the PATCH Lab who came out to support Penn's 5K for the IOA!

Congratulations to Dr. Lasya Sreepada on her successful PhD Thesis Defense! Thank you to her mentors, Drs. McMillan and Wolk, for their support. Looking forward to seeing where science takes you, @lasyasreepada.github.io! Check out Dr. Sreepada's dissertation: repository.upenn.edu/entities/pub...

Really happy that the final paper of my PhD is out now! It was great to work on this project with Dave Wolk (@picslupenn.bsky.social) & @lemwisse.bsky.social and all others involved! See below for more information! 👇

@biofinder.bsky.social · last yr.

🚨This study led by @anikawuestefeld.bsky.social aims to provide a more granular understanding of how tau pathology leads to specific cognitive decline in Alzheimer's disease. 🧠 Out now in Alzheimer’s & Dementia! Read it here: doi.org/10.1002/alz.... 🧵👇

Here are the poster presentations we have lined up for AAIC this week; please stop by! #AAIC25 #PennatAAIC25 @pennmemorycenter.bsky.social @alzassociation.bsky.social

Looking forward to AAIC25 in Toronto! We have some very exciting talks and posters to present; here's the of list of talks to check out: #AAIC25 #PennatAAIC25 @pennmemorycenter.bsky.social @alzassociation.bsky.social

Hello Bluesky! Welcome to the official Penn ADRD Trajectories, Copathology, and Heterogeneity (PATCH) Lab account for the labs of Drs. Paul Yushkevich, Sandhitsu Das, and David Wolk at the University of Pennsylvania. Stay tuned for updates about our presentations at AAIC25!