You remember our #ALife paper from 2023? doi.org/10.1162/isal.... One of my favourites! Experimental results are in, finally. You will most definitely enjoy reading about them. Coming soon! @lewisgrozinger.bsky.social @pglekas.eurosky.social
Juan Rico
@juanricomol.bsky.social
Biologist. Working on novel synthetic biology chassis, biosensors, cell cognition, evolution and biological control. Currently at I2SysBio.
Ready for three days of exciting discussions to celebrate the anniversary of our research institute @i2sysbio.es
Definitely, a conference to follow closely and great research conducted by Crislaine at the Biocomputation lab @cnb-csic.bsky.social. Go meet her for details! #SynBYSS
Angel Goñi-Moreno@angelgm.eurosky.social · 5mo agoNext conference in the Lab's agenda: the #SynBYSS conference that starts today in Barcelona. The agenda is absolutely spectacular: www.jcvi.org/events/synbyss. If you are around, go visit Crislaine Rocha at poster 17. Her research, on coupling sensors to gates is truly brilliant. #synbio
What if living cells compute in ways that silicon never can? Rather than mimicking computers, the future of biocomputation may lie in harnessing the unique information-processing strategies of evolution. Check this paper by @angelgm.eurosky.social and co. www.sciencedirect.com/science/arti....
Paper out!! 🥳 We controlled bacterial growth by tuning native RNAP availability. Then, we studied the impact of growth and this RNAP availability over different NOT gates present in that strain. Great work with @mirobueno.bsky.social and @angelgm.eurosky.social 😀. link.springer.com/article/10.1...
Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering
The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...
link.springer.com
Volviendo a Valencia después de una productiva visita al Instituto de Investigaciones Marinas de Vigo (IIM-CSIC). Agradecido a David Henriques por recibirnos y mostrarnos sus pioreactors para la caracterización de circuitos genéticos en levaduras. Que ganas de probarlos en el @i2sysbio.es
Recientemente ha fallecido Margarita Orejas, científica titular en el @iatacsic.bsky.social. Nuestro compañero Miguel Peñalva, en cuyo grupo del @cib-csic.bsky.social realizó una productiva estancia postdoctoral en la década de los 90, ha preparado este sentido texto a modo de homenaje.
(1/5) As promised, here a short thread about this work. Why Pseudomonas protegens Pf-5? It is a key environmental host with unique interactions with soil’s biotic and abiotic compounds. Thus great for our Lab’s goal: ecosystems computing. We needed to know how this host interacts with circuits.
Angel Goñi-Moreno@angelgm.eurosky.social · 8mo agoLatest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...
I just joined the Computational Synthetic Biology group at @i2sysbio.es. Looking forward to exciting science and new challenges. Thanks to the people of the Biocomputation Lab at @cnb-csic.bsky.social for the amazing last few years.
Great to see this one out. I agree it was challenging but watching it unfold was definitely exciting. The team worked brilliantly, truly thankful!
Angel Goñi-Moreno@angelgm.eurosky.social · 8mo agoLatest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...
New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...
Kudos to @crislaineksr.bsky.social and all the team on the publication of this review doi.org/10.1016/j.mi... regarding the complexity gap between current synthetic biology designs and the natural computing power of microbes.
Redirecting
doi.org
Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!
Angel Goñi-Moreno@angelgm.eurosky.social · 11mo agoPreprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)
Angel Goñi-Moreno@angelgm.eurosky.social · 11mo agoPreprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1
Growth control as a central regulator for tuning the cellular context
The cellular context interacts with genetic circuits, decisively defining their performance. However, contextual dependencies (the interplay between the host and the circuit) are often difficult to en...
biorxiv.org
The CSIC @csic.es Doctoral Programme in #SyntheticBiology is currently offering 10 PhD positions on a number of projects. Good opportunities! syntheticcell.eu/synbio-csic-...
SynBio CSIC is recruiting 10 doctoral researchers
The doctoral programme in synthetic biology, run by the Spanish National Research Council, is recruiting 10 doctoral researchers
syntheticcell.eu
Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...
Next in the Lab's conference agenda: Synthetic Biology UK #SBUK. Always a target event for us! Look for Lewis @lewisgrozinger.bsky.social to hear about biocomputation and evolution: "Evolutionary algorithms to design biocomputing circuits beyond logic gates" - an upgrade of our #ALIFE 2023 story.
The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!
If you are attending the Designer Biology conference at Newcastle, do not miss the chance to speak to Crislaine Rocha and Paula Múgica at their posters re biosensors and quorum sensing toolkits for #Pseudomonas. www.efbiotechnology.org/designerbiol...
Designer Biology
Designer Biology Conference, 29–31 July 2025 in Newcastle, UK. This event gathers bioengineering and synthetic biology scientists to explore applications like protein engineering and materials.
efbiotechnology.org
Next in Lab's conference agenda: Designer Biology! www.efbiotechnology.org/designerbiol... Paula Múgica has a poster on her recently published quorum sensing tools, and Crislaine Rocha will talk about environmental biosensors as input to logic gates.
Designer Biology
Designer Biology Conference, 29–31 July 2025 in Newcastle, UK. This event gathers bioengineering and synthetic biology scientists to explore applications like protein engineering and materials.
efbiotechnology.org
El grupo de Angel Goñi lidera un proyecto "Proof of Concept" @erc.europa.eu para desarrollar gemelos digitales pioneros y analizar en profundidad el comportamiento de células vivas Más info: www.cnb.csic.es/proyecto-de-... @angelgm.bsky.social @csic.es @sommalliance.bsky.social
Looking forward to great science at #EESMicrobiology. If you are around Heidelberg this week, come visit me at poster 220 to discuss about host-controlled reconfigurability of genetic circuits. New approaches and concepts in microbiology www.embl.org/about/info/c...
New approaches and concepts in microbiology
embl.org
Jungle Express promoter. Large dynamic range, low leak. Keeps expression tight, especially on low copy plasmids. Induced by cationic dyes—we use crystal violet. Has allowed us to clone some pretty toxic phage genes. www.nature.com/articles/s41...
Jungle Express is a versatile repressor system for tight transcriptional control - Nature Communications
Tightly regulated promoters with strong inducibility and scalability are highly desirable for biological applications. Here the authors describe ‘Jungle Express’, a EilR repressor-based broad host sys...
nature.com
New position at the @cnb-csic.bsky.social. I re-join @angelgm.bsky.social's lab. Exciting times ahead!