Latest paper just out! Chromosomal location reprograms genetic circuit function. 🔗 www.nature.com/articles/s41... We spent years working on this piece. Circuit function can be reprogrammed solely through spatial positioning. I hope you enjoy reading it - and let us know if any questions.

Muy ilusionado de ver cómo el proyecto NEWTON Biotwins newtonbiotwins.com, creado junto a @angelgm.eurosky.social, sigue dando importantes pasos hacia adelante.

CSIC@csic.es · 3w ago

🔬Cuatro proyectos del #CSIC reciben ayudas de la @caixaresearch.bsky.social en las convocatorias de Investigación en Salud y de Innovación en Salud 🧠Los proyectos abordarán análisis celular, cribado neonatal, diabetes y enfermedades neurodegenerativas ➡️https://f.mtr.cool/f06yoyura0

De Iniesta a Ferrán: dos estrellas y 16 años de cambio climático. Qué bueno esto de @edurobayna.bsky.social en @climatica.coop. +10% de concentración de CO₂. +36% de calentamiento. +5% de 5,5 cm de aumento de nivel del mar. +3.500 gigatoneladas de hielo perdidos en Groenlandia.

The 2026 Systems Biology Department's retreat. What a brilliant crowd! The t-shirt (artist: Marina de la Fuente) has a logo of every lab in the Dept. Our Lab is The logic Doors :-) Kudos to organizers: @angeles-hg.bsky.social, @pglekas.eurosky.social, @lewisgrozinger.bsky.social & Guillermo Gomez.

Paper out!! 🥳 We controlled bacterial growth by tuning native RNAP availability. Then, we studied the impact of growth and this RNAP availability over different NOT gates present in that strain. Great work with @mirobueno.bsky.social and @angelgm.eurosky.social 😀. link.springer.com/article/10.1...

📣 Latest paper out! I'll write a thread about it next week: growth control, cellular context, genetic circuits... A fascinating story by @angeles-hg.bsky.social & @mirobueno.bsky.social #synbio #biocomputation link.springer.com/article/10.1...

Growth control as a central regulator for tuning the cellular context - Journal of Biological Engineering

The cellular context decisively shapes genetic circuit performance, but the interplay between host and circuit remains difficult to control rationally. To address this challenge, we replaced the nativ...

link.springer.com

Este miércoles, a las 19h, estaré en el Moe’s Club (Madrid) en el @pintofscience.es de Madrid 😄. Representando al @cnb-csic.bsky.social, hablaré de si los ordenadores pueden estar vivos y cómo podemos crearlos en el laboratorio. ¡Nos vemos allí!

David Rodríguez habla de los retos y tribulaciones que tuvo que pasar hasta conseguir que Pseudomonas putida degradara 2,4 dinitrotolueno, un típico residuo de la producción de explosivos y un legado importante de conflictos bélicos cienciaes.com/entrevistas/...

Years from 1953 to 1968 were mindblowing for MolBio. Double helix, central dogma, genetic code... Since then, any related discovery has been that earthshaking. I wonder where the next mine of scientific discoveries is for understanding how life (or the world) works. I guess in physics... ideas?

Great to see this one out. I agree it was challenging but watching it unfold was definitely exciting. The team worked brilliantly, truly thankful!

Angel Goñi-Moreno@angelgm.eurosky.social · 8mo ago

Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...

Latest paper out! This piece was a challenge: logic, predictability, decidability, non-model organisms, design... Kudos to @juanricomol.bsky.social & Pablo Japón #syntheticbiology #synbio #biocomputation (I'll post more on this next week) www.sciencedirect.com/science/arti...

Dynamics of genetic circuits in Pseudomonas protegens

Genetic circuit engineering enables new cellular functions, yet most circuits are developed in the model host Escherichia coli, limiting their availab…

sciencedirect.com

New tech adventure: co-founded Newton Biotwins together with @mirobueno.bsky.social. We're building #DigitalTwins for the lab — starting with a flow cytometry twin. Turning #biology into an information science! newtonbiotwins.com/en/home_en/

Cuando escucho noticias trágicas en la tele, y veo con horror cómo les ponen banda sonora (normalmente emotiva, a veces Bob Dylan o similar...), disfrazan de cine lo que no tiene ni una pizca de belleza. La actualidad sobre la desgracia no debería plantearse con sentido estético. Porque no lo tiene.

New paper out!📢 Exploring the computing power of microbes that shapes the environment. In this short review we talk about the "complexity gap", the distance between bottom-up genetic circuits and microbial information processes. Key questions to improve #biocomputation. 🔗 doi.org/10.1016/j.mi...

Side story: NAND gates where one input deals directly with growth control, and it is the actual physical body doing the computation. This is our initial approach to morphological computing in living cells. #biocomputation #alife Our new strain KT-TTX is truly fascinating. Feedback welcome!

Angel Goñi-Moreno@angelgm.eurosky.social · 11mo ago

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

Preprint of our work tuning bacterial growth, something that changes context for genetic circuits and therefore, their behaviour. Very interesting observations from both experimental results and a model describing it in this piece of work with @mirobueno.bsky.social and @angelgm.bsky.social! :)

Angel Goñi-Moreno@angelgm.eurosky.social · 11mo ago

Preprint out! By controlling growth, via RNAP, we control the entire cellular machinery, and tune the cellular context into distinct, stable states. See how NOT gates behave! Kudos to @angeles-hg.bsky.social and @mirobueno.bsky.social 🔗https://www.biorxiv.org/content/10.64898/2025.12.19.695408v1

After 16 years listening to @patrickwolf.music-social.com, today I finally met him in a concert. His amazing music put a soundtrack to all the high and low moments of my life since then ❤️ Thanks for that company, Patrick!

Our #ALIFE2025 paper is out! 🎉 We show that even when two circuits produce the same output, their evolutionary potential can differ greatly. #Evolution at the smallest scale. “Parameter Evolvability in Gene Expression Models Drives Phenotypic Adaptation” 🔗 direct.mit.edu/isal/proceed...

If you are at the Emerging Applications of Microbes conference in Leuven, go to poster #24: Engineering growth control to modulate circuit host dependencies, by @angeles-hg.bsky.social. This is a brilliant story about growth rates vs. genetic circuit function. And, of course, noise! #synbio

The 2025 Retreat of the Biocomputation Lab (in wonderful Chinchón, Madrid) comes to an end. Three days of fantastic discussions, with new (and revisited) goals ahead. What a brilliant team!

Breaking News: Jane Goodall, one of the world’s most revered conservationists, died at 91. Her discoveries in the 1960s about how chimpanzees behaved in the wild broke new ground and represented what was called “one of the Western world’s great scientific achievements.” nyti.ms/42kpGxt

Esta tarde, @angeles-hg.bsky.social y yo estaremos en el Espacio Fundación Telefónica (Gran Vía, Madrid) representando al @cnb-csic.bsky.social en el Talento Show de la Noche Europea de los Investigadores Puedes venir a vernosgratis a las 17h o conectarte a www.youtube.com/live/z3eLvP0... :)

Noche Europea de investigadores 2025. El CSIC te llama esta noche. Talent show y concierto Biolocas

YouTube video by Espacio Fundación Telefónica Madrid

youtube.com

Llega la Noche de los Investigadores!! El viernes que viene estaremos, @redquena.bsky.social como monologuista veterano y yo como novata, junto a @cnb-csic.bsky.social y otros centros @csic.es hablando de ciencia! Podrá verse en directo en el canal de YT de #EspacioFTef #EuropeanResearchersNight

Centro Nacional de Biotecnología (CNB)@cnb-csic.bsky.social · last yr.

Este viernes te esperamos con talleres y actividades 🧬🌱 junto a los demás centros @csic.es Cantoblanco 📅 26 septiembre ⏰16:00h 📍Espacio Fundación Telefónica Madrid ℹ️ https://f.mtr.cool/bmeugfyigt #EuropeanResearchersNight

Today I submited my first science communication project. Independently of the result, I feel as if I completed something important!! #Fecyt Let’s go! 🥳🥳

a woman in a purple dress is doing a split

ALT: a woman in a purple dress is doing a split

media.tenor.com

"Rebajar impuestos a los ricos conduce a una mayor desigualdad tanto en el corto como en el medio plazo, sin ningún efecto en el crecimiento económico o el desempleo"

Very happy to see the final version published of our collaboration with Pavel Dvorak's lab! 🦠🧬 doi.org/10.1093/synb...

Construction of a syntrophic Pseudomonas putida consortium with reciprocal substrate processing

Abstract. Synthetic microbial consortia can leverage their expanded enzymatic reach to tackle biotechnological challenges too complex for single strains, s

doi.org

El grupo de Angel Goñi lidera un proyecto "Proof of Concept" @erc.europa.eu para desarrollar gemelos digitales pioneros y analizar en profundidad el comportamiento de células vivas Más info: www.cnb.csic.es/proyecto-de-... @angelgm.bsky.social @csic.es @sommalliance.bsky.social

Cuando presentamos el libro "Ciencia o Pseudociencia" hace ya 2 años, me dieron 10 minutos y carta blanca para hablar de lo que considerara oportuno. Preparé esta charlita divulgativa con mucha ilusión, y la comparto ahora por aquí, porque más vale tarde que nunca 🙂 youtu.be/4yChJadojhQ

La belleza del método lógico-deductivo. Fragmento presentación libro CIENCIA O PSEUDOCIENCIA [...]

YouTube video by Angeles Hueso-Gil

youtu.be

Just out! Want to use quorum sensing (QS) for cell–cell communication? Check this out — you might find it useful! Kudos to Paula Múgica 👏 Standardized Quorum Sensing Tools for Gram-Negative Bacteria | @pubs.acs.org @acs.org #SyntheticBiology @sevaplasmids.bsky.social pubs.acs.org/doi/10.1021/...

Standardized Quorum Sensing Tools for Gram-Negative Bacteria

Engineering synthetic consortia to perform distributed functions requires robust quorum sensing (QS) systems to facilitate communication between cells. However, the current QS toolbox lacks standardized implementations, which are particularly valuable for use in bacteria beyond the model species Escherichia coli. We developed a set of three QS systems encompassing both sender and receiver modules, constructed using backbones from the SEVA (Standard European Vector Architecture) plasmid collection. This increases versatility, allowing plasmid features like the origin of replication or antibiotic marker to be easily swapped. The systems were characterized using the synthetic biology chassis Pseudomonas putida. We first tested individual modules, then combined sender and receiver modules in the same host, and finally assessed the performance across separate cells to evaluate consortia dynamics. Alongside the QS set, we provide mathematical models and rate parameters to support the design efforts. Together, these tools advance the engineering of robust and predictable multicellular functions.

pubs.acs.org

Just published! Paula Mugica has standardized a set of #quorumsensing tools for its use in gramnegative bacteria. Their utility range from the development of #synbio #circuits inside a cell to what is even cooler: for cell to cell communication :) pubs.acs.org/doi/10.1021/...

Standardized Quorum Sensing Tools for Gram-Negative Bacteria

Engineering synthetic consortia to perform distributed functions requires robust quorum sensing (QS) systems to facilitate communication between cells. However, the current QS toolbox lacks standardized implementations, which are particularly valuable for use in bacteria beyond the model species Escherichia coli. We developed a set of three QS systems encompassing both sender and receiver modules, constructed using backbones from the SEVA (Standard European Vector Architecture) plasmid collection. This increases versatility, allowing plasmid features like the origin of replication or antibiotic marker to be easily swapped. The systems were characterized using the synthetic biology chassis Pseudomonas putida. We first tested individual modules, then combined sender and receiver modules in the same host, and finally assessed the performance across separate cells to evaluate consortia dynamics. Alongside the QS set, we provide mathematical models and rate parameters to support the design efforts. Together, these tools advance the engineering of robust and predictable multicellular functions.

pubs.acs.org