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Pooja Gupta

@poojag96.bsky.social

Postdoc @STRUBI (Oxford) - anti-influenza drug discovery, dabbles in cryo-ET PhD @YSBL (York) - the bioenergetics of bacterial spore germination I do microbiology, biochemistry, structural biology, biophysics whilst listening to a lot of radio/cricket

16 Posts87 Follower132 Folgt
Matt Johnson@profmattjohnson.bsky.social · 4d ago

Great to share our new preprint on Chlamy’s chloroplast ATP synthase at 2.2 Å we see 13 c subunits, a modified redox regulation and a complete Grotthuss proton wire 🦠☀️ www.biorxiv.org/content/10.6...

A 13-subunit c-ring in the Chlamydomonas chloroplast ATP synthase lowers the H⁺/ATP cost of carbon fixation

The chloroplast F1Fo ATP synthase is a rotary motor that converts the light-driven proton-motive force into the chemical energy of ATP. The number of c-subunits in its rotor fixes the number of proton...

biorxiv.org

Astronomer Royal for Scotland | Catherine Heymans@astroroyalscot.bsky.social · 4mo ago

Yesterday, 56 of our fab colleagues at the Physics & Astronomy dept in Nottingham, received “at risk of redundancy” letters. The Uni is planning to reduce the size of the Physics dept by almost a third.🧪⚛️🔭 Sign this petition to show them your support ✍️: nottinghamphysics.github.io/Open_Letter/

Petition statement We, the undersigned, call on the University of Nottingham to reverse its plans to impose compulsory redundancies on its staff in the School of Physics and Astronomy. The University threatens to cut twenty members of staff out of the seventy one currently in the School. On 12 May, fifty six of those members of staff received letters notifying them that they were at risk of redundancy. This affects academic and technical staff at all levels, from Research Fellows to Professors.
Astronomer Royal for Scotland | Catherine Heymans@astroroyalscot.bsky.social · 4mo ago

STFC cuts will accelerate the closure of UK physics departments, even though everyone recognises the importance & value of physics to UK PLC. Physics is explicitly listed as an area affected by planned compulsory redundancies at Nottingham. So sad to see this. www.theguardian.com/education/20...

Adrià Sogues@adriasogues.bsky.social · 5mo ago

This one deserves it🤩! We used cryo‑EM to identify a new “sporesilk” in Bacillus thuringiensis. The fiber, called A‑ENA, forms an incredibly stable covalent network that increases virulence by keeping the toxic payload and spores in a biofilm-like structure. www.nature.com/articles/s41...

Auto-crosslinking sporesilk fibers promote endospore and Cry toxin clustering - Nature Communications

Authors reveal that protein nanofibrils govern assembly of bacterial spores and extrasporal toxins into insecticidal aggregates. Spores and parasporal bodies are incased in a “sporesilk” matrix that d...

nature.com

Chris H. Hill@chillzaa.bsky.social · last yr.

New cryo-EM/ET story - a brilliant collaboration with Sergey Melnikov's lab in Newcastle @sergeymelnikov.bsky.social and Stefan Pfeffer's lab in Heidelberg @pfeffercryolab.bsky.social. Great work in particular by Karla Helena-Bueno and @sophiekopetschke.bsky.social www.nature.com/articles/s41...

Structurally heterogeneous ribosomes cooperate in protein synthesis in bacterial cells - Nature Communications

Cells can simultaneously produce structurally dissimilar ribosomes, suggesting functional specialization of distinct ribosome populations. Here, the authors show that distinct ribosomes cooperate rath...

nature.com

Pooja Gupta@poojag96.bsky.social · last yr.

The preprint is out now - we describe how Bacillus spores restart energy metabolism as they exit dormancy! Dormant spores are dehydrated, very robust for long periods, but when they sense nutrient availability, they can germinate rapidly to make the most of the favourable environmental conditions 1/

bioRxiv Biophysics@biorxiv-biophys.bsky.social · last yr.

Bioenergetic metabolism restarts alongside germinant sensing and hydration in bacterial spore germination https://www.biorxiv.org/content/10.1101/2025.03.13.642030v1