Preprint 🧵! I’m really excited to introduce BIGSMALL, an interleaved multi-magnification cryo-ET scheme bridging molecular and cellular scales in a single acquisition! BIGSMALL = 𝐁road 𝐈nformation 𝐆athering 𝐒trategy by 𝐌ultiscale 𝐀cquisition of lame𝐋𝐋a www.biorxiv.org/content/10.6... (1/6)

Our new paper (with @biotay.bsky.social) is out and on the cover story of @currentbiology.bsky.social !!!! Veronika, a Carinthian mountain cow flexibly uses a “multi-purpose tool” to scratch herself. A video and more information will follow in the comments. www.cell.com/current-biol...

CryoET of microbes inside an animal organ? Yes it’s possible! Check out our new preprint showing how we did it! What an amazing collaboration with amazing scientists who made this possible!

bioRxiv Microbiology@biorxiv-microbiol.bsky.social · 8mo ago

Nanoscale imaging of native symbiotic animal tissue using amultimodal large volume imaging pipeline for cryo-electrontomography https://www.biorxiv.org/content/10.1101/2025.11.30.691379v1

if you have to do MFA twice in the same "day": go to bed

Lokiarchaea are tricky to work with in the lab: they grow very slowly, exclusively in an oxygen free environment with the presence of symbiotic bacteria. But with careful nurturing, scientists hope to witness their cell division at work.

Tiny Tubes Reveal Clues to the Evolution of Complex Life | Quanta Magazine

Scientists have identified tubulin structures in primitive Asgard archea that may have been the precursor of our own cellular skeletons.

quantamagazine.org

repurposing library monitors #upthearsenal

hot (well, cold) off the press! ❄️ well done @glynnca.bsky.social & @michaelgrange.bsky.social & fabulous co-authors 👏🏼 #teamtomo #cryoET

Michael Grange@michaelgrange.bsky.social · last yr.

And here it is now in print! www.cell.com/cell-reports... With a front cover splash 😍

Delighted to see our work in press! 🙌🔬🧠 Thanks to @glynnca.bsky.social, @michaelgrange.bsky.social and the rest of the fabulous co-authors for all your contributions. Excited to see where in tissue structural cell biology goes next 👀! #liftlaughlove #teamtomo #whopper

Michael Grange@michaelgrange.bsky.social · last yr.

Proud to share our latest paper. doi.org/10.1016/j.cr... Through the dedication of @glynnca.bsky.social and @cryingem.bsky.social we report a thorough method to image molecular organisation within hippocampus tissue. Structural biology in tissue is well and truly here! @rosfrankinst.bsky.social

inspiring and relatable talk from @alisterburt.bsky.social #ccpem

note to self: don't turn out of office replies on

Exploring shaped focused ion beams for lamella preparation https://www.biorxiv.org/content/10.1101/2025.04.01.646235v1

Check out our paper on Xenon milling of HPF samples, now online @naturecomms.bsky.social rdcu.be/eczIb

Barista: How caffeinated would you like to be? Me: Yes

Isolated in just 3 years! (previously, 12 years). We obtained two strains from 'Hodarchaeales', proposed to be closest to our archaeal ancestor. Our analysis suggests the ancestor was an anaerobic, syntrophic, peptidotrophic, archaeon with a simple intracellular structure and possible aerotolerance.

Eukaryotes' closest relatives are internally simple syntrophic archaea

Eukaryotes are theorized to have originated from an archaeal phylum Promethearchaeota (formerly 'Asgard' archaea)1,2. The first cultured representatives revealed valuable insight3,4 but are distantly ...

biorxiv.org

A great opportunity! (especially to hear @glynnca.bsky.social spread the plasma gospel🙌🏻)

Simone Mattei@simonemattei.bsky.social · last yr.

Thanks to Instruct-ERIC, the @embl.org Imaging Centre is able to offer an advanced hands-on workshop on cryo-FIB-SEM methods. This is a great opportunity to exchange knowledge with our fantastic cryo-CLEM specialists! 21-25 July 2025. Apply here before May 12th: www.embl.org/about/info/i...

Congrats Charlie & co.! The use of optogenetics for in tissue CLEM here is really elegant.

cryoEM papers@cryoempapers.bsky.social · 2y ago

Memory engram synapse 3D molecular architecture visualized by cryoCLEM-guided cryoET pubmed.ncbi.nlm.nih.gov/39829918/

A long read from 2017 but well worth the time for any scientist who both loves their job and and often finds themselves questioning their life decisions. www.danielnettle.org.uk/wp-content/u...

We have quite a range of PhD projects this year, covering cryo-EM methods, bacteriology/bioenergetics, and infection/antibiotics/vaccines. Would really appreciate if people can RT and share with their teams!

Is there such thing as TEMTuesday? Maybe CryoETuesday? Myelinated axon cross section with microtubules and intermediate filaments:

it is nicer over here