Sensing the skeleton: sensorineural regulation in bone - Nature Reviews Neuroscience

The skeleton is innervated by neurons that convey sensory information to the CNS and release neuroregulatory peptides to influence the bone microenvironment. James and colleagues describe the mechanis...

nature.com

Nobel Prize in Physiology or Medicine 2026

The 2026 Nobel Prize in Physiology or Medicine has been awarded jointly to Karl Deisseroth, Peter Hegemann and Georg Nagel “for discoveries leading to ...

nature.com

Quantum computing for neuroscience: opportunities beyond classical limits - Nature Reviews Neuroscience

Some of the least understood phenomena in the brain emerge from interactions between local and global brain states, yet representing their joint activity is a considerable computational challenge. As ...

nature.com

Towards an integrative neuroscience of metacognition - Nature Reviews Neuroscience

The capacity to self-evaluate and control one’s own cognitive performance, known as metacognition, underpins adaptive learning, social behaviours and self-belief. Stephen Fleming outlines our current ...

nature.com

High-performance handwriting brain–computer interfaces - Nature Reviews Neuroscience

In this Journal Club, Yu Qi discusses a 2021 study that reported a brain–computer interface that used neural activity in the motor cortex to decode attempted handwriting in real time.

nature.com

The ventral hippocampus: computations, circuits and functions - Nature Reviews Neuroscience

Recent years have witnessed major advances in our understanding of the distinct functional and computational roles of the ventral hippocampus (vHPC). Mazen Kheirbek and colleagues examine the state-de...

nature.com

Defining the electrical synapse - Nature Reviews Neuroscience

The mechanisms underlying electrical transmission are often viewed as relatively simple compared with those mediating chemical transmission, yet electrical synapses exhibit dynamic changes in structur...

nature.com

Making models disagree to learn how brains compute - Nature Reviews Neuroscience

Neural network models can express computational hypotheses about brain information processing, but their high parametric capacity makes discriminating model alignment to experimental data challenging....

nature.com

Early life stress primes future stress vulnerability - Nature Reviews Neuroscience

Early-life exposure to stressors can lead to increased stress susceptibility in later life, shown here to be mediated in mice by SETD7-mediated monomethylation of H3K4 in dopaminergic neurons of the v...

nature.com

Early life experiences, the neural epigenome and affective disorder risk - Nature Reviews Neuroscience

Understanding how early life stress becomes biologically embedded remains a major challenge in neuroscience. In this Review, Maze and colleagues discuss recent advances in cell-type-specific epigeneti...

nature.com

Neural circuits for mammalian parental behaviour - Nature Reviews Neuroscience

Parental care is a conserved and robust feature of mammalian reproductive behaviour, but is highly variable, even within individuals. Jamieson and Kohl describe the neural circuits that drive parental...

nature.com

Neural circuits for mammalian parental behaviour - Nature Reviews Neuroscience

Parental care is a conserved and robust feature of mammalian reproductive behaviour, but is highly variable, even within individuals. Jamieson and Kohl describe the neural circuits that drive parental...

nature.com

Cerebellar rhythms: mechanisms, functions and translational opportunities - Nature Reviews Neuroscience

Neural oscillations across a range of frequencies contribute to the cerebellum’s roles in perception, prediction and action. Koch and colleagues describe the microcircuit dynamics through which cerebe...

nature.com

Dopaminergic mechanisms in frontal cortex for the control of top-down attention - Nature Reviews Neuroscience

In this Journal Club, Guilhem Ibos reflects on a 2011 study linking the neurophysiology of attention with the neuromodulation of cognitive functions.

nature.com

Unlocking spontaneous cognition in the age of data science - Nature Reviews Neuroscience

Spontaneous brain activity is experimentally unconstrained. Embracing this freedom unlocks rich opportunities beyond task-based and naturalistic paradigms, the traditional Herculean pillars of constra...

nature.com

What scrub jays have taught us about the neural intersection of memory and action selection - Nature Reviews Neuroscience

In this Journal Club, Laura Bradfield discusses a 1998 study showing that scrub jays exhibit episodic-like memory.

nature.com

Heading into the wild: setting the course to natural neuroscience - Nature Reviews Neuroscience

In this Journal Club, M. Jerome Beetz highlights a study published 2021 that examined hippocampal representation of large environments in flying bats.

nature.com

Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation - Nature Reviews Neuroscience

In this Tools of the Trade article, Omid Yaghmazadeh describes the proof-of-concept development of transcranial radio frequency stimulation in mice, a potentially scalable and effective therapeutic pl...

nature.com

Resolving rapid cell-surface proteome remodelling in intact neural circuits - Nature Reviews Neuroscience

In this Tools of the Trade article, Colleen McLaughlin describes endocytome profiling, a systematic and quantitative approach for monitoring of cell-surface protein remodelling in the intact brain.

nature.com

When inhibition organizes the brain - Nature Reviews Neuroscience

In this Journal Club, Renata Batista-Brito discusses a 2009 study that showed that a population of inhibitory hub neurons orchestrate network synchrony in the developing hippocampus.

nature.com

Microglial states revisited: from homeostasis to disease - Nature Reviews Neuroscience

Transcriptomic microglial states are shaped by development, ageing, genetics, environment and disease. In this Review, Eggen and Kooistra discuss how the formation of so-called hidden immune-memory st...

nature.com

Brain mitochondria as key drivers of cognition and behaviour - Nature Reviews Neuroscience

Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...

nature.com

Using human 3D organoid models to gain mechanistic insight in motor neuron diseases - Nature Reviews Neuroscience

Motor neuron disorders involve complex interactions between multiple CNS cell types, which are challenging to model in 2D in vitro conditions. Frizzi and colleagues describe recent advances in induced...

nature.com