Dopaminergic mechanisms in frontal cortex for the control of top-down attention - Nature Reviews Neuroscience

In this Journal Club, Guilhem Ibos reflects on a 2011 study linking the neurophysiology of attention with the neuromodulation of cognitive functions.

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Unlocking spontaneous cognition in the age of data science - Nature Reviews Neuroscience

Spontaneous brain activity is experimentally unconstrained. Embracing this freedom unlocks rich opportunities beyond task-based and naturalistic paradigms, the traditional Herculean pillars of constra...

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What scrub jays have taught us about the neural intersection of memory and action selection - Nature Reviews Neuroscience

In this Journal Club, Laura Bradfield discusses a 1998 study showing that scrub jays exhibit episodic-like memory.

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Heading into the wild: setting the course to natural neuroscience - Nature Reviews Neuroscience

In this Journal Club, M. Jerome Beetz highlights a study published 2021 that examined hippocampal representation of large environments in flying bats.

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Non-invasive deep-brain neuromodulation by transcranial radio frequency stimulation - Nature Reviews Neuroscience

In this Tools of the Trade article, Omid Yaghmazadeh describes the proof-of-concept development of transcranial radio frequency stimulation in mice, a potentially scalable and effective therapeutic pl...

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Resolving rapid cell-surface proteome remodelling in intact neural circuits - Nature Reviews Neuroscience

In this Tools of the Trade article, Colleen McLaughlin describes endocytome profiling, a systematic and quantitative approach for monitoring of cell-surface protein remodelling in the intact brain.

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When inhibition organizes the brain - Nature Reviews Neuroscience

In this Journal Club, Renata Batista-Brito discusses a 2009 study that showed that a population of inhibitory hub neurons orchestrate network synchrony in the developing hippocampus.

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Microglial states revisited: from homeostasis to disease - Nature Reviews Neuroscience

Transcriptomic microglial states are shaped by development, ageing, genetics, environment and disease. In this Review, Eggen and Kooistra discuss how the formation of so-called hidden immune-memory st...

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Brain mitochondria as key drivers of cognition and behaviour - Nature Reviews Neuroscience

Neuronal and glial mitochondria support neuronal circuit function and plasticity through the supply of energetic substrates and the regulation of cellular physiology. Sandi and colleagues describe how...

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Using human 3D organoid models to gain mechanistic insight in motor neuron diseases - Nature Reviews Neuroscience

Motor neuron disorders involve complex interactions between multiple CNS cell types, which are challenging to model in 2D in vitro conditions. Frizzi and colleagues describe recent advances in induced...

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Acetylcholine: a candidate substrate for hippocampal predictive learning? - Nature Reviews Neuroscience

Predictive models have emerged as a normative lens for understanding neural function. In this Perspective, de Cothi, Shipley and Barry plausibly unify the diverse roles of hippocampal acetylcholine in...

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Astrocytes viewed through the lens of their proteomes and subproteomes - Nature Reviews Neuroscience

Recent technological advances have provided novel understanding of the spatiotemporal relationship between gene expression and protein levels. In this Review, Khakh and colleagues summarize recent wor...

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m6A in RNA: a key regulator of brain development, function and disease - Nature Reviews Neuroscience

N6-Methyladenosine (m6A) is installed on many mRNAs and non-coding RNAs and regulates gene expression by affecting RNA–protein interactions. In this Review, Enakshi Sivasudhan and Kate Meyer discuss h...

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The AMPA receptor life cycle: assembly, regulation and synaptic diversity - Nature Reviews Neuroscience

AMPA receptors (AMPARs) mediate fast excitatory neurotransmission in the brain. Derek Bowie and colleagues describe recent advances in our understanding of the regulatory layers that operate across th...

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Neural basis of social hierarchy across species

Nature Reviews Neuroscience - Structured social hierarchies, in which individuals differ in their access to resources and influence over other group members, are a characteristic of many social...

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Linking the exposome to the brain–behaviour phenotype - Nature Reviews Neuroscience

Many physical, social, lifestyle and systemic body factors — collectively termed the ‘exposome’ — can influence brain and behavioural phenotypes across the lifespan. In this Perspective, Sarah Genon a...

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Neural basis of social hierarchy across species - Nature Reviews Neuroscience

Structured social hierarchies, in which individuals differ in their access to resources and influence over other group members, are a characteristic of many social species. Rongzhen Yan and Dayu Lin d...

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Opportunities and pitfalls of data contextualization in neuroimaging - Nature Reviews Neuroscience

Despite rapid exploitation of the opportunities that contextualization of brain maps affords, potential limitations have received little attention. In this Roadmap, Royer et al. provide practical guid...

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Rethinking hierarchy: the auditory system as an integrated cortical–subcortical network - Nature Reviews Neuroscience

The auditory system differs from other senses in the complexity of its subcortical pathways. King and colleagues examine how subcortical structures transform sound representations and integrate sensor...

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Large-scale electrophysiology at single-spike resolution - Nature Reviews Neuroscience

Recent advances in large-scale electrophysiology now enable researchers to record from thousands of neurons distributed across the brain. Siegle and Steinmetz describe the principles underlying this t...

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Wired for immunity: neuroimmune control of the lung by sensory neurons - Nature Reviews Neuroscience

Lung diseases drive substantial hospitalization, but available therapies remain limited. In this Review, Talbot and colleagues highlight pulmonary neuroimmunology — the bidirectional crosstalk between...

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Categorization is ‘baked’ into the brain - Nature Reviews Neuroscience

Categorization, the grouping of objects, living organisms, actions or events into equivalence clusters, is fundamental to adaptive behaviour. In this Perspective, Barrett and Miller discuss evidence t...

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Role of dysregulated calcium homeostasis in astrocytes in neurodegenerative disorders - Nature Reviews Neuroscience

Astrocytic Ca2+ signalling is a fundamental and highly spatiotemporally nuanced mechanism for maintaining brain homeostasis. In this Review, Bacskai and colleagues discuss how astrocytic Ca2+ homeosta...

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Clarifying the conceptual dimensions of representation in neuroscience - Nature Reviews Neuroscience

Appeals to representation are widespread, despite neuroscientists’ uncertainty about what kind of findings count as evidence for such claims. In this Perspective, Pohl and colleagues develop a unified...

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