New work from the Simons Collaboration on the Global Brain points to a potential therapeutic target for Huntington’s disease: https://bit.ly/3SPEJxu #science #neuroscience

Neuron Stimulation Improves Symptoms in Mouse Model of Huntington’s Disease

Using targeted light stimulation, scientists successfully recalibrated damaged brain circuits to restore movement and motor learning in mice.

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What if part of Huntington's disease wasn't just damage, but a circuit stuck in the wrong pattern? Our new paper, out today in Nature, tests that idea.

Motor deficits in Huntington's disease mice were rescued by targeted activation of cortical inhibitory neurons. As a winner of the Emerging Neuroscientist Seminar Series, Dr Sonja Blumenstock, UCSD, explains her findings: www.sainsburywellcome.org/qa/targeting... #BrainAwarenessWeek

So excited to present my research at ENSS 2025/2026!

Sainsbury Wellcome Centre@sainsburywellcome.bsky.social · last yr.

Congratulations to the SWC Emerging Neuroscientists Seminar Series winners! - Dimokratis Karamanlis, University of Geneva - @rafsarnataro.bsky.social‬ & Peter S. Hasenhuetl, @ox.ac.uk - Saurabh Vyas, @columbiauniversity.bsky.social - @sblumenstock.bsky.social‬, University of California San Diego

Hi Bluesky, past time for an introduction! I’m Sonja, a Neuroscientist at UCSD. I track + tweak cortical circuits in Huntington’s disease using 2P imaging & optogenetics — to see how specific neurons fail, and how to fix them. Always up for talking circuits, neurodegeneration & smart analysis ideas.

Linear regression is all you need