Tessera

Brooke M. Emerling

@bemerling.bsky.social

Cosimo Commisso @cosimocommisso.bsky.social · last yr.

Thrilled to share our first collaboration with @bemerling.bsky.social 🎉 Fantastic work by first author Dr. Gurpreet Arora showing how PI5P4Kα fuels pancreatic cancer cell fitness and reveals a new therapeutic vulnerability. www.cell.com/cell-reports...

PI5P4Kα promotes glucose and iron acquisition to support metabolic fitness in pancreatic cancer

PI5P4Kα is a critical metabolic gatekeeper in PDAC, promoting glucose and iron acquisition to support tumor survival. Arora et al. demonstrate that PI5P4Kα suppression disrupts the metabolic flexibili...

cell.com

Cosimo Commisso @cosimocommisso.bsky.social · last yr.

New preprint with @bemerling.bsky.social + first author Dr. Preeti Arora: PI5P4Kα supports pancreatic cancer cell survival by maintaining iron. Knockdown disrupts iron homeostasis, triggers apoptosis, and blocks tumor growth. A potential new target. www.biorxiv.org/content/10.1...

PI5P4Kα Regulates Iron Balance to Promote Metabolic Fitness in Pancreatic Cancer

Phosphoinositide kinases generate distinct phosphoinositides that regulate processes that maintain cellular fitness. Phosphatidylinositol 5-phosphate 4-kinases (PI5P4Ks) have garnered interest for the...

biorxiv.org

Nature Reviews Cancer @natrevcancer.nature.com · last yr.

#REVIEW 🚨 Brooke Emerling & Co @sbpdiscovery.bsky.social @bemerling.bsky.social summarize the roles of phosphatidylinositol 4-kinases #PI4Ks and phosphatidylinositol phosphate kinases #PIPKs in cancer. 📖 ⬇️

Phosphoinositide kinases in cancer: from molecular mechanisms to therapeutic opportunities - Nature Reviews Cancer

In this Review, Emerling and colleagues summarize the roles of phosphatidylinositol 4-kinases (PI4Ks) and phosphatidylinositol phosphate kinases (PIPKs) in cancer. They highlight the altered expression of these kinases in tumours and discuss ongoing efforts in developing therapies targeting these lesser-studied phosphoinositide kinase families.

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