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LIFE Profillinie

@lifeprofile.bsky.social

The LIFE profile @UniJena supports and promotes excellent, interdisciplinary, innovative research within the life sciences and medicine.

45 Posts63 Follower27 Folgt
Universität Jena@uni-jena.de · 4w ago

Mit der Förderung will die #UniJena Spitzenforschung stärken, Wissenschaftler*innen gewinnen und fördern, neue Freiräume für inter- und transdisziplinäre Zusammenarbeit schaffen, Forschung und Lehre enger verbinden sowie Transfer und gesellschaftliche Wirkung stärken.

Universität Jena@uni-jena.de · 4w ago

Die #UniJena erhält den Status einer Exzellenzuniversität! Die Exzellenzkommission hat den Antrag „Light. Life. Liberty. – Connecting People and Ideas“ am heutigen 2.Oktober positiv entschieden. 🥳

Das Hauptgebäude der Friedrich-Schiller-Universität Jena mit den Flaggen "LIGHT. LIFE. LIBERTY. Connecting people and ideas." Foto: Nicole Nerger / Uni Jena
Universität Jena@uni-jena.de · 2mo ago

Which ideas have what it takes to bring down walls? At the FALLING WALLS LAB Jena on Thursday 10 September, students, early-career researchers and innovators at #UniJena will present their ideas in just three minutes. Admission is free, but registration is requested. ➡️ www.uni-jena.de/fallingwalls

A young man presents his idea on stage as part of a Falling Walls lab.
NFDI4Chem@nfdi4chem.de · 7mo ago

Next STAMMTISCH: ⠀ Our Speaker Christoph Steinbeck will be presenting: Deep Learning and Open Data in Molecular Informatics Join our 50th talk and celebrate with us while listening to an entertaining and fascinating talk. 📆24 April 2026, 2 p.m. CET⠀ https://t1p.de/nx11o ⠀ #chemistry

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Ute Hellmich@hellmichgroup.bsky.social · 7mo ago

New paper out with our friends the Nina Morgner Lab on how to quantify homodimer affinities by native MS 💕 pubs.acs.org/doi/10.1021/... Never thought it possible, but this concludes our JACS triple - 3 papers in 3 months 😋🥳🧪 @crc1507.bsky.social @microverse.bsky.social @lifeprofile.bsky.social

Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry

Biological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (KD), plays a crucial role in basic research and must be monitored throughout the development of drugs and agrochemicals. An ideal method for KD determination is applicable to various analytes with a large range of affinities, tolerates complex matrix compositions, does not require labeling, and simultaneously provides information on the structural integrity of the binding partners. Native mass spectrometry meets these criteria but typically struggles with homooligomeric complexes due to overlapping mass signals. To overcome this, we resolve monomer/dimer contributions to overlapping MS-peaks by separately analyzing the charge state distribution of each oligomeric species via sample dilution and covalent cross-linking. Following this approach, we show that quantitative laser-induced liquid bead ion desorption mass spectrometry (qLILBID-MS) accurately captures the affinities of Bovine Serum Albumin (BSA) and chemically induced dimers of Tryparedoxin (Tpx), an oxidoreductase from human pathogenic Trypanosoma brucei parasites, with various molecular glues and homodimer affinities. Conveniently, qLILBID-MS requires a fraction of sample used by other methods such as isothermal titration calorimetry (ITC) and yields previously inaccessible protein homodimer KDs in the high micromolar range, which allowed us to monitor the gradual decrease in homodimer affinity via mutation of crucial dimer interface contacts. Overall, qLILBID-MS is a sensitive, robust, fast, scalable, and cost-effective alternative to quantify protein/protein interactions, that can accelerate contemporary drug discovery workflows, e.g. the efficient screening for proximity inducing molecules like proteolysis targeting chimera (PROTACs) and molecular glues.

pubs.acs.org

Ute Hellmich@hellmichgroup.bsky.social · 8mo ago

We were featured in C&EN! 🤯🥳🧪 Amazing experience with @pstallforth.bsky.social & @mlakemeyer.bsky.social! 😍 More on bacterial cooperation, D,L-peptidases, natural product structure determination & backstory: cen.acs.org/biological-c... @microverse.bsky.social @lifeprofile.bsky.social @uni-jena.de

Bacterial enzymes help reveal natural product stereochemistry

The peptidases can break bonds between specific <small>D</small>- and <small>L</small>-amino acids, filling a gap in the toolbox for natural products characterization

cen.acs.org

Ute Hellmich@hellmichgroup.bsky.social · 9mo ago

🧪Bacterial DL-peptidases are key in coordindated predetor defenses AND powerful tools for natural product structure elucidation! 🦠✂️ New JACS paper with @pstallforth.bsky.social @mlakemeyer.bsky.social @en-hxnu-enment.bsky.social & Hertweck labs @microverse.bsky.social pubs.acs.org/doi/10.1021/...

Balance of the Microverse@microverse.bsky.social · 9mo ago

Microbial Tag-Team! 🦠🤝 Researchers at our #ClusterOfExcellence found that bacteria cooperate to survive: One makes the compound, the other uses "molecular scissors" to turn it into a weapon against predators. A breakthrough for #DrugDiscovery! 💊 ➡️ www.microverse-cluster.de/en/news/micr...

Microbial Tag-Team: Researchers Decode Joint Defense Strate…

A team at the Cluster of Excellence "Balance of the Microverse" reveals how two bacterial species cooperat…

microverse-cluster.de

Balance of the Microverse@microverse.bsky.social · 9mo ago

TV feature alert! 📺 Great to see our PIs @hellmichgroup.bsky.social & Michael Bauer on MDR. They explain why understanding microbial balance is crucial for our future. 🦠 Catch the full clip here: www.mdr.de/video/mdr-vi... 🤝 @lifeprofile.bsky.social & @uni-jena.de

Forschung zu resistenten Keimen macht Fortschritte | MDR.DE

Seit 100 Jahren können Bakterien mit Antibiotika gut behandelt werden. Doch inzwischen sind auch multiresistente Keime im Umlauf, die immun gegen die Medikamente sind. An der Uni Jena forscht man an e...

mdr.de

LIFE Profillinie@lifeprofile.bsky.social · 10mo ago

Erster interdisziplinärer Austausch im botanischen Garten Light, Life & Liberty mit unserem Gast Prof. Sebastian Seiffert aus Mainz ist gestartet! Wir freuen uns auf seinen Vortrag heute Abend 17:15 Uhr.

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Balance of the Microverse@microverse.bsky.social · 10mo ago

𝗦𝘁𝘂𝗱𝗲𝗻𝘁 𝗦𝗹𝗼𝘁: 𝗔𝗰𝘁𝗶𝗻𝗴 𝗜𝗻𝘀𝘁𝗲𝗮𝗱 𝗼𝗳 𝗛𝗼𝗽𝗶𝗻𝗴 Join the Student Slot linked to the lecture “Chemistry Professor and Climate-Acceptist: Acting Instead of Hoping” on 15 Jan 2026. Students discuss climate action, science, and society. 🔗 More & registration: www.uni-jena.de/380666/lll-c...

Chemieprofessor und Klima-Akzeptist: Handeln statt Hoffen

Öffentlicher Vortrag der LIGHT. LIFE. LIBERTY. Reihe

uni-jena.de

Balance of the Microverse@microverse.bsky.social · 11mo ago

Congratulations to our PI @hellmichgroup.bsky.social! 🎉 🤝 @lifeprofile.bsky.social & @uni-jena.de

Ute Hellmich@hellmichgroup.bsky.social · 11mo ago

Super nice to wake up to the news that our paper on bidirectional communication in an ABC transporter has been selected as a Nature Communications Editors’ Highlight in “Structural biology, biochemistry and biophysics"! 🥳 🥳 🥳 www.nature.com/articles/s41... @microverse.bsky.social