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LIFE Profillinie

@lifeprofile.bsky.social

The LIFE profile @UniJena supports and promotes excellent, interdisciplinary, innovative research within the life sciences and medicine.

44 Posts63 Follower27 Folgt
NFDI4Chem@nfdi4chem.de · 4mo ago

Next STAMMTISCH: ⠀ Our Speaker Christoph Steinbeck will be presenting: Deep Learning and Open Data in Molecular Informatics Join our 50th talk and celebrate with us while listening to an entertaining and fascinating talk. 📆24 April 2026, 2 p.m. CET⠀ https://t1p.de/nx11o ⠀ #chemistry

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Ute Hellmich@hellmichgroup.bsky.social · 4mo ago

New paper out with our friends the Nina Morgner Lab on how to quantify homodimer affinities by native MS 💕 pubs.acs.org/doi/10.1021/... Never thought it possible, but this concludes our JACS triple - 3 papers in 3 months 😋🥳🧪 @crc1507.bsky.social @microverse.bsky.social @lifeprofile.bsky.social

Quantifying Protein Homodimer Affinities and the Effect of Molecular Glues and Interface Residues Using Native Mass Spectrometry

Biological processes rely on finely tuned homo- and heteromeric interactions between (biomacro)molecules. The strength of an interaction, typically given by the dissociation constant (KD), plays a crucial role in basic research and must be monitored throughout the development of drugs and agrochemicals. An ideal method for KD determination is applicable to various analytes with a large range of affinities, tolerates complex matrix compositions, does not require labeling, and simultaneously provides information on the structural integrity of the binding partners. Native mass spectrometry meets these criteria but typically struggles with homooligomeric complexes due to overlapping mass signals. To overcome this, we resolve monomer/dimer contributions to overlapping MS-peaks by separately analyzing the charge state distribution of each oligomeric species via sample dilution and covalent cross-linking. Following this approach, we show that quantitative laser-induced liquid bead ion desorption mass spectrometry (qLILBID-MS) accurately captures the affinities of Bovine Serum Albumin (BSA) and chemically induced dimers of Tryparedoxin (Tpx), an oxidoreductase from human pathogenic Trypanosoma brucei parasites, with various molecular glues and homodimer affinities. Conveniently, qLILBID-MS requires a fraction of sample used by other methods such as isothermal titration calorimetry (ITC) and yields previously inaccessible protein homodimer KDs in the high micromolar range, which allowed us to monitor the gradual decrease in homodimer affinity via mutation of crucial dimer interface contacts. Overall, qLILBID-MS is a sensitive, robust, fast, scalable, and cost-effective alternative to quantify protein/protein interactions, that can accelerate contemporary drug discovery workflows, e.g. the efficient screening for proximity inducing molecules like proteolysis targeting chimera (PROTACs) and molecular glues.

pubs.acs.org

Ute Hellmich@hellmichgroup.bsky.social · 5mo ago

We were featured in C&EN! 🤯🥳🧪 Amazing experience with @pstallforth.bsky.social & @mlakemeyer.bsky.social! 😍 More on bacterial cooperation, D,L-peptidases, natural product structure determination & backstory: cen.acs.org/biological-c... @microverse.bsky.social @lifeprofile.bsky.social @uni-jena.de

Bacterial enzymes help reveal natural product stereochemistry

The peptidases can break bonds between specific <small>D</small>- and <small>L</small>-amino acids, filling a gap in the toolbox for natural products characterization

cen.acs.org

Ute Hellmich@hellmichgroup.bsky.social · 6mo ago

🧪Bacterial DL-peptidases are key in coordindated predetor defenses AND powerful tools for natural product structure elucidation! 🦠✂️ New JACS paper with @pstallforth.bsky.social @mlakemeyer.bsky.social @en-hxnu-enment.bsky.social & Hertweck labs @microverse.bsky.social pubs.acs.org/doi/10.1021/...

Balance of the Microverse@microverse.bsky.social · 6mo ago

Microbial Tag-Team! 🦠🤝 Researchers at our #ClusterOfExcellence found that bacteria cooperate to survive: One makes the compound, the other uses "molecular scissors" to turn it into a weapon against predators. A breakthrough for #DrugDiscovery! 💊 ➡️ www.microverse-cluster.de/en/news/micr...

Microbial Tag-Team: Researchers Decode Joint Defense Strate…

A team at the Cluster of Excellence "Balance of the Microverse" reveals how two bacterial species cooperat…

microverse-cluster.de

Balance of the Microverse@microverse.bsky.social · 6mo ago

TV feature alert! 📺 Great to see our PIs @hellmichgroup.bsky.social & Michael Bauer on MDR. They explain why understanding microbial balance is crucial for our future. 🦠 Catch the full clip here: www.mdr.de/video/mdr-vi... 🤝 @lifeprofile.bsky.social & @uni-jena.de

Forschung zu resistenten Keimen macht Fortschritte | MDR.DE

Seit 100 Jahren können Bakterien mit Antibiotika gut behandelt werden. Doch inzwischen sind auch multiresistente Keime im Umlauf, die immun gegen die Medikamente sind. An der Uni Jena forscht man an e...

mdr.de

LIFE Profillinie@lifeprofile.bsky.social · 7mo ago

Erster interdisziplinärer Austausch im botanischen Garten Light, Life & Liberty mit unserem Gast Prof. Sebastian Seiffert aus Mainz ist gestartet! Wir freuen uns auf seinen Vortrag heute Abend 17:15 Uhr.

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Balance of the Microverse@microverse.bsky.social · 7mo ago

𝗦𝘁𝘂𝗱𝗲𝗻𝘁 𝗦𝗹𝗼𝘁: 𝗔𝗰𝘁𝗶𝗻𝗴 𝗜𝗻𝘀𝘁𝗲𝗮𝗱 𝗼𝗳 𝗛𝗼𝗽𝗶𝗻𝗴 Join the Student Slot linked to the lecture “Chemistry Professor and Climate-Acceptist: Acting Instead of Hoping” on 15 Jan 2026. Students discuss climate action, science, and society. 🔗 More & registration: www.uni-jena.de/380666/lll-c...

Chemieprofessor und Klima-Akzeptist: Handeln statt Hoffen

Öffentlicher Vortrag der LIGHT. LIFE. LIBERTY. Reihe

uni-jena.de

Balance of the Microverse@microverse.bsky.social · 8mo ago

Congratulations to our PI @hellmichgroup.bsky.social! 🎉 🤝 @lifeprofile.bsky.social & @uni-jena.de

Ute Hellmich@hellmichgroup.bsky.social · 8mo ago

Super nice to wake up to the news that our paper on bidirectional communication in an ABC transporter has been selected as a Nature Communications Editors’ Highlight in “Structural biology, biochemistry and biophysics"! 🥳 🥳 🥳 www.nature.com/articles/s41... @microverse.bsky.social

LIFE Profillinie@lifeprofile.bsky.social · 8mo ago

The 4th LIFE Symposium with its Satellite Event connecting LIFE, LIBERTY and society, ends today, but we will see which bonds will be formed after the event. The energy of this day was incredible! Thank you all for shaping these LIFE events!

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LIFE Profillinie@lifeprofile.bsky.social · 8mo ago

The 4th LIFE Symposium 2025 is ready to start: soon researchers, innovators, and industry leaders will fill the tables to exchange ideas, knowledge, and collaborations. Under the motto ‘Connecting ideas, people, and innovations,’ an inspiring day of insights and networking awaits.✨

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