Compare the benefits and harms of drugs for obesity in our large network meta-analysis (262 trials including almost 100K patients). Some surprising results, such as as the effects on quality of life at 1 year. Have a look ! 👇

The BMJ@bmj.com · 4w ago

Despite substantial weight loss, most obesity drugs such as Wegovy and Mounjaro do not meaningfully improve quality of life and few show cardiovascular benefits at one year, finds a new study in The BMJ https://bit.ly/4gmXim6 Read the linked commentary https://bit.ly/4f67A7I

Notre invitation, mardi 2 juin aux HUG, pour célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes. @hug-ge.bsky.social 👉 www.hug.ch/evenement/10... fr.linkedin.com/posts/hopita...

#partenariat #patients #hôpital #genève | HUG - Hôpitaux Universitaires de Genève

Mardi 2 juin 2026 aux HUG, venez célébrer une décennie d’initiatives et de projets réalisés à l’hôpital en partenariat avec les patients et patientes qui en font l’expérience au quotidien. Un événemen...

fr.linkedin.com

Clinician-in-the-loop: a flawed model for the safe deployment of AI in healthcare. www.bmj.com/content/393/...

Spice-GRADE: methodological breakthrough for #GRADE. New methods showing how indirect evidence from epidemiological investigations of mechanistic causal pathways can complement direct evidence. pubmed.ncbi.nlm.nih.gov/41802581/

SPICE-GRADE: simultaneous processing of indirect causal evidence in complex pathways using GRADE - an exploratory case study - PubMed

In this case study, we illustrate SPICE-GRADE as a structured way of mapping and assessing multiple causal links within the GRADE framework. Establishing SPICE-GRADE as a robust methodology for GRADE ...

pubmed.ncbi.nlm.nih.gov

Closing the gap between research and practice💥 At #REMEDY 2026, Per Olav Vandvik highlighted how MAGIC Evidence Foundation helps turn RCTs into decisions that change care. Evidence is not the endpoint. It is the starting point. Trials → guidelines → implementation → patient decisions. #MAGICevidence

💥New paper from #MAGICevidence community: #SPICEGRADE explores how to assess certainty of the evidence when causal inference relies on chains ⛓️ of indirect evidence. An important step as evidence ecosystems become more complex: www.jclinepi.com/article/S089...

This Rapid Recommendation is a summary of a WHO guideline for influenza www.bmj.com/content/392/...

"The notion that medical research is a 'geopolitical football' is much more than a hypothesis. It is a stark, complex, and miserable reality." @kamranabbasi.bsky.social in Editor's Choice https://bit.ly/3MBGY4y

From the US to China and India: the power shift in clinical trials

If you’re seeking to keep politics out of medicine, good luck with that. It isn’t possible. We’ve previously described the political determinants of health (doi:10.1136/bmj.h81),1 and next we’ll focus...

bmj.com

Celebrating 10 years of partnership between #MAGICevidence & @bmj.com BMJ Rapid Recs have grown from rapid translation of evidence into 🌏 rigorous, transparent patient-informed guidance, while also serving as a laboratory for innovation. Meeting in London was about celebration & renewed commitment

New research📢 Geertruida Bekkering and colleagues compare the effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illness. https://bit.ly/4kHE8Ye

Smoking cessation for people with severe mental illness: systematic review and network meta-analysis

Objective To evaluate the comparative effectiveness and safety of pharmacological and non-pharmacological smoking cessation interventions in people with severe mental illnessDesign Systematic review a...

bit.ly

MAGICapp was used worldwide in 2025: a shared infrastructure for evidence-based healthcare, supporting real decisions shaped by evidence, patient values, and global collaboration. Grateful to the community translating evidence into practice every day, everywhere.

A new Methods Primer by Dan Green and colleagues outlines circumstances where the mean and standard deviation alone are insufficient summary variables, and provides a simple appraisal method for reviewers without raw data Read in BMJ Medicine now: https://bit.ly/4bJz3w8

Do people register their #randomizedtrials before starting it ? We studied more than 1000 RCT in #rheumatology to answer this question, to see how it evolved in time and how it varied between RCTs⬇️ Just published in @jclinepi.bsky.social : jclinepi.com/article/S089... #Metaresearch #EpiSky

Prospective registration of trials: where we are, why, and how we could get better

Transparent trial conduct requires prospective registration of a randomized controlled clinical trial (RCT) before the enrollment of the first participant. We aimed to (1) estimate the proportion of R...

jclinepi.com

Latest asked question about Core #GRADE, essence of the GRADE approach to #evidence certainty and moving to #recommendations in #BMJ in 2025. Addresses when and how much to rate down for #imprecision. Joins GRADE for single study and a priori hypotheses explaining #heterogeneity t.co/hh6owWxn5O

Best wishes to all for 2026!

MAGIC Evidence Ecosystem Foundation@magicevidence.bsky.social · 7mo ago

MAGIC’s 2026 priorities: expanding digitally structured guidelines with #MAGICapp, strengthening global capability through education & Core GRADE, advancing BMJ Rapid Recs and applied AI, and connecting the evidence ecosystem to improve real-world impact. Open to collaboration in 2026 💥

MAGIC’s 2026 priorities: expanding digitally structured guidelines with #MAGICapp, strengthening global capability through education & Core GRADE, advancing BMJ Rapid Recs and applied AI, and connecting the evidence ecosystem to improve real-world impact. Open to collaboration in 2026 💥

[cont.] link to publication: bmjopen.bmj.com/content/15/1... @thomasagoritsas.bsky.social @chrischampion.bsky.social

Hot off the press from the #MAGICevidence team. New study on how guidelines translate into real-world use, focusing on BMJ Rapid Recs Key message: Methodological rigor builds credibility, but complexity can undermine usability and confidence Implementability needs to be designed, not assumed.

Old photo, guess 2010, recently recovered. The four people responsible for the MAGIC evidence ecosystem foundation – Per Vandvik, Thomas Agoritsas, Linn Brandt and me, along with former Chair of my department for a decade, Brian Haynes, and current Chair Alfonso Iorio. @thomasagoritsas.bsky.social

youtube.com/shorts/zg6AK...

The Geneva Conventions matter more than you may think

YouTube video by Samia Hurst

youtube.com

New in MAGICapp: you can now build Summary of Findings tables for Qualitative Evidence using the GRADE-CERQual framework. A big step toward transparent, structured presentation of qualitative findings in guidelines and evidence syntheses. #MAGICapp #GRADE #CERQual #QualitativeEvidence

At recent #GuidelinesInternationalNetwork (GIN) meeting with Thomas Agoritsas, Chair of the #MAGICEcosytemFoundation and international #GRADE methodology leader and our researcher Prashanti Eachempati, creator of the JUDGE instrument that will revolutionize GRADE education and practice.

Core #GRADE, 7 articles in #BMJ this spring, one-stop-shopping for those who want to get GRADE right with the essentials. Now also frequently asked question – latest post considers a priori hypotheses to explain #heterogeneity. All questions welcome, send to guyatt@mcmaster.ca t.co/hh6owWxn5O

A situation where this is no equipoise yet shared decision making can be helpful ... bmjpublichealth.bmj.com/content/3/2/...

Decision support tools in the absence of equipoise: the case for vaccination

Public health is in a bind. The goal of the discipline is to protect and improve the public’s overall health so that populations remain as healthy as possible. Public health considers decisions from a...

bmjpublichealth.bmj.com

Challenges with medical advice from social media influencers www.bmj.com/content/391/...

Responding to public health challenges of medical advice from social media influencers

Raffael Heiss and colleagues argue that influencers’ medical advice is often shaped by multiple biases and suggest how to reduce the associated risks Social media influencers have become powerful in ...

bmj.com

Ultra-processed foods – what’s the impact? In a new Lancet Series, experts warn a global rise in #UPFs presents a growing public health threat. Read the evidence & policy recommendations ⬇️ spkl.io/63327AduhR

Are #RelativeRisks overwhelmingly similar across risk groups? And if so, can we personalize care by applying relative risk to individual patients’ risk profiles? This key #EBM study demonstrates that the answer to both questions is an unquestionable YES. pubmed.ncbi.nlm.nih.gov/11914297/

Can we individualize the 'number needed to treat'? An empirical study of summary effect measures in meta-analyses - PubMed

The fixed effects OR, random effects OR and random effects RR appear to be reasonably constant across different baseline risks. Given the interpretational and arithmetic ease of RR, clinicians may wis...

pubmed.ncbi.nlm.nih.gov

Forming #EvidenceBased plans of #EBM care that respond to each patient’s situation demands #SharedDecisionMaking. JP Brito, Iris Hargraves, and Marleen Kunneman are doing leading work to advance the practice of making care fit using shared decision making. ebm.bmj.com/content/28/4...

Shared decision-making as a method of care

Care happens in interaction between the patient and the clinician, in conversation where the patient and clinician uncover or develop a shared understanding of the problematic situation of the patient...

ebm.bmj.com

🚨⚕️Enhancing clinical encounters: our new systematic review on how hospitals’ institutional programs could protect or increase the time dedicated to interactions. It included 117 unique studies comprising 298,517 patients 👇 link.springer.com/article/10.1...

L'UE examine l'Initiative citoyenne européenne (ICE) visant à interdire les "thérapies de conversion" dans toute l'Europe. Les prochains mois sont essentiels – assurons-nous qu'elle agisse. J'ai signé. Rejoignez-moi 👉 a.allout.org/s/OJyE5/

Interdisons les « thérapies de conversion » dans l’UE !

L’UE examine l’Initiative citoyenne européenne (ICE) visant à interdire les “thérapies de conversion” dans toute l’Europe. Les prochains mois seront décisifs : agiront-ils vraiment ou détourneront-ils...

a.allout.org