How does the early life microbiota protect the infant against excessive adiposity? Our new preprint describes a mechanism by which specific members of the early life small intestine microbiota regulate intestinal epithelium-immune interactions to prevent adiposity. www.biorxiv.org/content/10.6...
Small intestine microbiota development prevents early-life adiposity via IL-22-mediated intestinal PPARα suppression
Perturbation to the early-life microbiota has long-term detrimental effects on health and development, leading to increased risk for metabolic dysfunction and childhood obesity. Despite the central ro...
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