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Nature Reviews Endocrinology

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We publish Reviews and opinion articles on all aspects of endocrinology and metabolism. https://www.nature.com/nrendo/

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Nature Reviews Endocrinology@natrevendo.nature.com · 8h ago

ICYMI: New content online: Gestational diabetes mellitus and risk of long-term cardiometabolic disease

Gestational diabetes mellitus and risk of long-term cardiometabolic disease

Nature Reviews Endocrinology, Published online: 12 November 2026; doi:10.1038/s41574-026-01327-9In this Review, the authors discuss the evidence for connections between gestational diabetes mellitus and later cardiometabolic disease in mothers and offspring. They also discuss potential biological mechanisms for increased cardiometabolic risk after gestational diabetes mellitus and ways of mitigating this risk.

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Nature Reviews Endocrinology@natrevendo.nature.com · yesterday

ICYMI: New content online: Screening for early-stage type 1 diabetes mellitus

Screening for early-stage type 1 diabetes mellitus

Nature Reviews Endocrinology, Published online: 11 November 2026; doi:10.1038/s41574-026-01323-zType 1 diabetes mellitus (T1DM) involves several presymptomatic stages in which autoantibodies can be detected, potentially allowing diagnosis before the onset of hyperglycaemia. This Review discusses possible strategies for T1DM screening and considers the benefits and challenges associated with widespread screening programmes.

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Nature Reviews Endocrinology@natrevendo.nature.com · 2d ago

New content online: Gestational diabetes mellitus and risk of long-term cardiometabolic disease

Gestational diabetes mellitus and risk of long-term cardiometabolic disease

Nature Reviews Endocrinology, Published online: 12 November 2026; doi:10.1038/s41574-026-01327-9In this Review, the authors discuss the evidence for connections between gestational diabetes mellitus and later cardiometabolic disease in mothers and offspring. They also discuss potential biological mechanisms for increased cardiometabolic risk after gestational diabetes mellitus and ways of mitigating this risk.

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Nature Reviews Endocrinology@natrevendo.nature.com · 3d ago

New content online: Screening for early-stage type 1 diabetes mellitus

Screening for early-stage type 1 diabetes mellitus

Nature Reviews Endocrinology, Published online: 11 November 2026; doi:10.1038/s41574-026-01323-zType 1 diabetes mellitus (T1DM) involves several presymptomatic stages in which autoantibodies can be detected, potentially allowing diagnosis before the onset of hyperglycaemia. This Review discusses possible strategies for T1DM screening and considers the benefits and challenges associated with widespread screening programmes.

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Nature Reviews Endocrinology@natrevendo.nature.com · 3d ago

ICYMI: New content online: Hypothalamic astrocytes fine-tune the signals governing metabolism

Hypothalamic astrocytes fine-tune the signals governing metabolism

Nature Reviews Endocrinology, Published online: 09 November 2026; doi:10.1038/s41574-026-01318-wAstrocytes are involved in the neuroendocrine control of metabolism and their known spectrum of actions continues to expand. In this Review, the authors discuss the roles of astrocytes in pathophysiological processes associated with poor nutrition and obesity, their roles in the physiological control of energy homeostasis and in circadian rhythms, and their potential as a therapeutic target in obesity treatments.

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Nature Reviews Endocrinology@natrevendo.nature.com · 5d ago

New content online: Hypothalamic astrocytes fine-tune the signals governing metabolism

Hypothalamic astrocytes fine-tune the signals governing metabolism

Nature Reviews Endocrinology, Published online: 09 November 2026; doi:10.1038/s41574-026-01318-wAstrocytes are involved in the neuroendocrine control of metabolism and their known spectrum of actions continues to expand. In this Review, the authors discuss the roles of astrocytes in pathophysiological processes associated with poor nutrition and obesity, their roles in the physiological control of energy homeostasis and in circadian rhythms, and their potential as a therapeutic target in obesity treatments.

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Nature Reviews Endocrinology@natrevendo.nature.com · last wk.

ICYMI: New content online: Targeting MMP9: an antibody strategy for diabetic peripheral neuropathy

Targeting MMP9: an antibody strategy for diabetic peripheral neuropathy

Nature Reviews Endocrinology, Published online: 03 November 2026; doi:10.1038/s41574-026-01322-0Disease-modifying therapies for painful diabetic peripheral neuropathy are urgently needed. A recent study published in Science Translational Medicine demonstrates that monoclonal antibodies that selectively inhibit the activity of matrix metalloproteinase MMP9 alleviate pain, reduce epidermal nerve fibre loss and enhance wound healing in preclinical models of painful neuropathy, highlighting MMP9 as a promising therapeutic target.

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Nature Reviews Endocrinology@natrevendo.nature.com · 2w ago

New content online: Targeting MMP9: an antibody strategy for diabetic peripheral neuropathy

Targeting MMP9: an antibody strategy for diabetic peripheral neuropathy

Nature Reviews Endocrinology, Published online: 03 November 2026; doi:10.1038/s41574-026-01322-0Disease-modifying therapies for painful diabetic peripheral neuropathy are urgently needed. A recent study published in Science Translational Medicine demonstrates that monoclonal antibodies that selectively inhibit the activity of matrix metalloproteinase MMP9 alleviate pain, reduce epidermal nerve fibre loss and enhance wound healing in preclinical models of painful neuropathy, highlighting MMP9 as a promising therapeutic target.

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Nature Reviews Endocrinology@natrevendo.nature.com · 2w ago

New content online: Cardiovascular disease in diabetes mellitus: beyond atherosclerosis and heart failure

Cardiovascular disease in diabetes mellitus: beyond atherosclerosis and heart failure

Nature Reviews Endocrinology, Published online: 03 November 2026; doi:10.1038/s41574-026-01315-zThis Review examines the associations between diabetes mellitus and some common cardiovascular diseases that are often overlooked in research and clinical care.

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Nature Reviews Endocrinology@natrevendo.nature.com · 3w ago

ICYMI: New content online: Food insecurity in the development of metabolic diseases

Food insecurity in the development of metabolic diseases

Nature Reviews Endocrinology, Published online: 20 October 2026; doi:10.1038/s41574-026-01314-0Food insecurity affects billions of people worldwide and is strongly linked to increased risk of non-communicable diseases. This Review explores the link between food insecurity and metabolic disease, and discusses potential social and healthcare interventions to mitigate the effects of food insecurity on metabolic health.

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Nature Reviews Endocrinology@natrevendo.nature.com · 4w ago

ICYMI: New content online: The genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

The genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

Nature Reviews Endocrinology, Published online: 19 October 2026; doi:10.1038/s41574-026-01316-yThe genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

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Nature Reviews Endocrinology@natrevendo.nature.com · 4w ago

New content online: Food insecurity in the development of metabolic diseases

Food insecurity in the development of metabolic diseases

Nature Reviews Endocrinology, Published online: 20 October 2026; doi:10.1038/s41574-026-01314-0Food insecurity affects billions of people worldwide and is strongly linked to increased risk of non-communicable diseases. This Review explores the link between food insecurity and metabolic disease, and discusses potential social and healthcare interventions to mitigate the effects of food insecurity on metabolic health.

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Nature Reviews Endocrinology@natrevendo.nature.com · 4w ago

New content online: The genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

The genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

Nature Reviews Endocrinology, Published online: 19 October 2026; doi:10.1038/s41574-026-01316-yThe genome-wide puzzle: utilizing GWAS to unveil the genetic architecture of polyendocrine metabolic ovarian syndrome

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Nature Reviews Endocrinology@natrevendo.nature.com · 4w ago

ICYMI: New content online: The β-cells in type 1 diabetes mellitus: findings from human pancreas studies

The β-cells in type 1 diabetes mellitus: findings from human pancreas studies

Nature Reviews Endocrinology, Published online: 16 October 2026; doi:10.1038/s41574-026-01312-2This Perspective discusses the latest findings from studies on the fate of pancreatic β-cells in type 1 diabetes mellitus and what these findings mean for our understanding of the development of the disease.

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