Heidi Ledford

@heidiledford.bsky.social

Reporter for Nature, mostly covering biology and medicine. hledford.01 (Signal) and heidiledford (@proton.me)

The bispecific antibodies, T-cell activators, attempt to bring the two cell types closer together, thereby stimulating the T-cell to attack the cancer cell. At least 12 such T-cell activators have been approved for the treatment of cancer, including leukemia & myeloma. @heidiledford.bsky.social

Cancer-fighting antibodies with a one-two punch take aim at tumours

Bispecific antibodies, which bind to two targets, are sweeping into the clinic and are prompting even more elaborate versions.

go.nature.com

🔴 We have a fun thing for you today in @nature.com - a game! We took the latest research into Mars terraforming and transformed it into an interactive adventure. 🌿 How would you make the red planet green? Try your hand and see if you can win. 🧪 www.nature.com/immersive/d4...

Can you terraform Mars? Try Nature’s game

Once the realm of science fiction, the idea of making Mars habitable is gaining traction. Nature consulted with key scientists to develop this experimental adventure.

nature.com

Not just an issue for AI: "Scientists and engineers who build powerful AI systems often understand the tools’ capabilities in extraordinary detail. What they resist — and sometimes cannot see — is that their technical choices are also political choices." www.nature.com/articles/d41...

I advise the Vatican and the UN on AI — don’t dismiss the Pope’s message as theology

The papal letter goes beyond a religious document and diagnoses a failure in AI governance that the scientific community should heed.

nature.com

"The results... do not mean that 6-8 hours is the optimum amount of sleep for every person, nor do they prove that achieving that ‘Goldilocks’ range of sleep each day directly improves health or slows ageing." @heidiledford.bsky.social on sleep study & impt caveats www.nature.com/articles/d41...

Sleep linked to slower ageing: huge study pinpoints the right amount

Health outcomes were better in people who slept between about six and eight hours a day.

nature.com

Characteristicaly good piece by @lizziegibney.bsky.social about how seriously (or not) to take AI doomsayers. The point is made here that AI researchers are not necessarily the best people to ask about social implications of the technology. To which I'd add that... www.nature.com/articles/d41...

AI doom warnings are getting louder. Are they realistic?

Researchers are increasingly sounding the alarm that artificial intelligence could end humanity. But such doomsday warnings carry their own risks.

nature.com

I'm on Capitol Hill watching NIH director Jayanta Bhattacharya testify to the Senate HELP committee. Thankfully I haven't been escorted out of this event (yet). Here's what I'm following. You can also watch live here: www.help.senate.gov/hearings/mod...

Modernizing the National Institutes of Health: Faster Discoveries, More Cures | The U.S. Senate Committee on Health, Education, Labor & Pensions

Full Committee Hearing on February 3, 2026 at 5:00 AM

help.senate.gov

Inspired by Fred Rogers, @nature.com asked readers to help us 'find the helpers' amid the crisis in American science. What emerged were inspiring stories of researchers, legal experts, data hounds and government scientists who are fighting the dismantling of the US research enterprise. 🧪🧵1/6

NIH director Jay Bhattacharya posted on X: "No clinical trial has been delayed, nor has any participant been dropped from clinical trial. These are the facts." Malaria, tuberculosis, cancer trials abroad have all been on the chopping block, leaving participants stranded, I reported in this story.

NIH grant cuts will axe clinical trials abroad — and could leave thousands without care

US agency’s new policy could abruptly end studies of infectious diseases and cancer, leaving researchers scrambling for funds.

nature.com

After ruling the NIH grant cuts were illegal yesterday, Judge Young, a Reagan appointee on the bench since 1985, ended the hearing with a blistering 15-minute speech. I've cleaned up my notes — here are his remarks in full. 🧵

Judge rules against NIH grant cuts — and calls them discriminatory

The decision means that the US biomedical agency has to restore funding to hundreds of research projects, but the government will likely appeal.

nature.com