So many people waking up today wishing they had prompted Fable a bit longer last night 😱 The government's reaction is completely overblown, of course. But it is a bit better than Opus 4.8 on average – enough that I wouldn't go back voluntarily if cost wasn't a factor

CryoARC: Atomic-resolution conformational landscapes of protein assemblies from cryo-EM single particles with evolutionary priors www.biorxiv.org/content/10.64898/2026.05.25.727696v1 #cryoEM

Genuinely is the new delve

MissAlignment is out!!! Our new software that improves reference-free tilt series alignment by mimicking human intuition. Check out Dimitry's beautiful thread for a quick summary! And the preprint for more details: www.biorxiv.org/content/10.6... The program: github.com/warpem/miss-...

Dimitry Tegunov@dtegunov.bsky.social · 3mo ago

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

We're super excited to share MissAlignment: a new ML-based approach to reference-free tilt series alignment, spearheaded by @martenchaillet.bsky.social. We think it's going to make your cryo-ET life a lot better. Preprint: www.biorxiv.org/content/10.6... Code: github.com/warpem/miss-... 🧶 Thread:

Now my mailing list reply bot is getting spam targeted specifically at agents: containing an API key for the advertised service, and instructions to try it out and to copy part of the message as a skill .md to Claude's config. I wonder how often Claws running without any human oversight bite on that

Looks like electron cryo-microscopy/tomography has finally lost the battle

cryoEM papers@cryoempapers.bsky.social · 4mo ago

Hello everyone! If you want to make sure your paper is posted here, the bot scrapes for the following keywords in the title and abstract from bioRxiv and PubMed: -cryoem -cryo-em -cryogenic electron microscopy -cryoet -cryo-et -cryogenic electron tomography -structural biology

Somewhat related: I was looking for a JS library to read MRC files a while ago, but couldn't find one (sorry if I missed it). So you can now “npm install @warpem/mrc-parser” github.com/warpem/mrc-p...

Dimitry Tegunov@dtegunov.bsky.social · 6mo ago

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

I had Claude make this as a mini-game for Relay's disconnect screen (like Chrome's dinosaur), but then pivoted to stand-alone. In this game, you have to find Euler angles matching the target projection, i.e. cosplay RELION. It can be pretty hard. Works on mobile too! warpem.github.io/euler-hunt/

Euler Hunt

Can you find the Euler angles of a cryo-EM projection?

warpem.github.io

Once you install peonping.com, don't forget to mute the volume if you decide to claude something during a meeting

peon-ping — Stop babysitting your terminal

Game character voice lines as notifications for Claude Code, Codex, Cursor, Antigravity & more. Never miss when your AI agent needs you.

peonping.com

A cats lock key that lets you quickly disable the keyboard when a cat approaches it would be a lot more useful than the antiquated caps lock

What is the current resolution record for in situ nucleosomes? The best unofficial result I remember seeing was around 7 Å, but I feel like I've heard a better figure mentioned somewhere already

California is famous for its sunsets, but sunny early mornings are the real magic here

Do we have “I am a robot” CAPTCHAs for Moltbook yet?

Super happy to finally see native vertical tabs in Chrome, but why why why is the + button all the way at the bottom? #uxsky

If someone's age is a prime number, are they in their prime?

This exciting new method has a bright future!

Great CV advice in this thread! I'll also add that for computational scientists, a GitHub/GitLab link is a must. Sure, there are people whose work I know well enough to not care about their repos, but don't bet on that.

Alexis Rohou@alexisrohou.bsky.social · 7mo ago

I've reviewed about 150 CVs in the past few days. A few observations: (1) I am sooo impressed by the talent pool out there; (2) do not try to make your CV fit onto one page if it makes things difficult to read - just go multipage, keeping the key messages upfront;

2026 will bring great tilt series alignments for the ribosome-deficient among us 🎆

Here is why friends don't let friends calculate FSC on denoised half-maps. I took EMD-17961, denoised the maps using Warp's Noise2Map, and calculated the FSC between various things. With noise gone from the half-maps, their consistency is no longer related to SSNR. Denoised map vs. model still works

Lars-Anders Carlson@lacarlson.bsky.social · 8mo ago

The icecream manuscript calculated FSCs between "half-tomograms" and compared to other methods (Fig. 3). Does that also qualify as a good comparison in your view? Just curious.

Don't get me wrong: the original IsoNet was the coolest thing to happen in cryoET in at least a decade. But after the initial “wow” moment it's time to make this topic more sciency

Dimitry Tegunov@dtegunov.bsky.social · 8mo ago

It would be a great start if the individual methods papers could quantify the quality of their own results instead of relying on visual vibes

I'm not superstitious but I never set my TV's volume to 13

I'm used to seeing driverless Waymos at this point, but seeing a Waymo with no driver *and* no passengers roll down a hill still gave me a moment of “OMG THE PARKING BRAKE FAILED” panic

Cool, definitely a visual improvement! But do I understand correctly the FSC was calculated between 2 *denoised* half-maps? You can't quantify resolution like that, only consistency.

AI x Bio Discovery@aixbiobot.bsky.social · 10mo ago

Icecream: High-Fidelity Equivariant Cryo-Electron Tomography [new] Equivariant imaging for cryo-ET denoising/recovery via self-supervision & dose-split data.

😂

TJ McCorvie@allostericstate.bsky.social · 10mo ago

Zoom-ins to show the remaining parts of these erased curves in the upper left of the plot and the gridlines:

OMG they will go so well with my Bliss ugly Christmas sweater

The Verge@theverge.com · 10mo ago

You can now buy Microsoft’s Windows XP Crocs for $79.95

It took me several weeks to notice how perfect this arrangement was

The things Apple will do to procrastinate improving Siri

Alexis Verger 🧬🧫🧪@alexis-verger.cpesr.fr · 11mo ago

iFold, sorry, SimpleFold, by Apple arxiv.org/html/2509.18...

Ugh, I'm starting to get spam texts with em dashes

Happy to announce "Technical Innovations Using #SerialEM: A Community Meeting", a new format of hybrid meeting David Mastronarde and I are organizing in April 2026. For more info, a preliminary list of speakers, pre-registration etc. visit www.nexperion.net/semcm2026