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Marten Chaillet

@martenchaillet.bsky.social

CryoET open-source software developer 🤓 Postdoc to tackle tilt-series alignment with deep-learning. Working in Arjen Jakobi's lab at the technical university of Delft. interests outside of work: DnD, cooking, road-cyling!

52 Posts642 Follower248 Folgt
napari@napari.org · 5d ago

And it's a wrap! The hackathon was a fantastic success! 🥳 You can look forward to a longer post about all we did, and one of our biggest releases yet in 0.9.0! Huge thanks to all the participants 🤩, and we hope to see you at the next one!

Hackathon participants discussing a new feature demo.Jules Vanaret shows off slicing of volumes with non-orthogonal transforms.The naPLari hackathon crowd: Wouter-Michiel Vierdag, Grzegorz Bokota, Tim Monko, Giannis Liaskas, Draga Doncila Pop, Lorenzo Gaifas, Aroj Hada, Brian Northan, Jules Vanaret, Zuzana Čočková, Curtis Rueden, Juan Nunez-Iglesias, and Margot Chazotte.Celebratory drink after the last full day of the hackathon. 🍻
napari@napari.org · 3mo ago

🎉 Announcing the naPLari hackathon in Kraków, Poland 🇵🇱, July 24–29 2026, after EuroSciPy! Hack on napari, join deep dives, meet the team. All experience levels welcome! 📝 Register by July 1: napari.typeform.com/naplari-hack #napari #ScientificPython #OpenSource #EuroSciPy #BioImageAnalysis

Laina Hall@lainahall.bsky.social · 2w ago

With Cryo-ET/EM, the macromolecules we study (and biological questions we ask) are SNR-limited. Here, we share Nilas, a low-voltage milling method named after thin sea ice. Nilas produces thin (sub 50 nm in places!), minimally damaged lamellae. biorxiv.org/content/10.64898/2026.07.21.739890v1

Optimized cryo-FIB milling strategy to generate thin, minimally damaged biological lamellae

Focused ion beam (FIB)-milling has been adapted to thin frozen cells for visualization of macromolecular structures in situ with cryogenic electron microscopy. However, only a few large and abundant c...

biorxiv.org

Matti Pronker@mfpronker.bsky.social · 2w ago

We have a PhD position at Sanquin Research in Amsterdam involving protein engineering, de novo design and antibody development related to bleeding disorders. Please share this with anybody to whom this may be relevant! 🩸 🧬 🧪 🧫 www.sanquin.nl/en/working-a... www.linkedin.com/jobs/view/44...

Sanquin hiring PhD Candidate: Antibody Therapy for Bleeding Disorders in Amsterdam, North Holland, Netherlands | LinkedIn

Posted 10:24:43 AM. The Division of Research and Lab Services of Sanquin is home to 250 researchers, including over 60…See this and similar jobs on LinkedIn.

linkedin.com

SAHASA 🐙🪸@sculptedreef.com · last mo.

Did you know octopuses are technically colorblind? 🌈 One photoreceptor, no color vision, should only see in grayscale. So how are they perfect color matching camouflage artists? 🐙 A thread 🧵 (with sources at the end, of course 😋) 🦑🐡

Katharina Geißler@kgeissler.bsky.social · last mo.

What is the best way to distribute the electron dose across your tilt series in cryo ET? Thanks to Maarten Tuijtel, we finally know --> head over to eLife for the publication! doi.org/10.7554/eLif...

Optimising the tilt-increment for in situ cryo-electron tomography

doi.org

Max Planck Institute of Biophysics@mpibp.bsky.social · last mo.

1/3: We are excited to share a new study by Maarten Tuijtel from @becklab.bsky.social, published in eLife. 🔬 🎉 The work addresses a key question in cryo-electron tomography: how to best distribute the limited electron dose across a tilt series while balancing angular sampling and image quality. 💥

Cryo-EM images showing sample structures at tilt increments from 1 to 10 degrees, with resolution patterns and measured values in nanometers.
Edward T Eng@edwardteng.bsky.social · last mo.

What if learning structural biology felt more like playing a game? Meowtabolism aims to make the structural sciences more interactive, accessible & fun. If you have educational applications let Muyuan (or me) know. store.steampowered.com/app/4045010/... #CryoEM #ScienceOutreach #STEMEducation

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Edward T Eng@edwardteng.bsky.social · 10mo ago

Muyuan Chen has turned structural biology into an immersive experience with his new video game Meowtabolism, now available on Steam. Try the demo here: store.steampowered.com/app/4045010/... Give Muyuan feedback: steamcommunity.com/app/4045010 #ScienceGaming #StructuralBiology #CryoEM #STEMOutreach

Nikolai Slavov@slavov-n.bsky.social · last mo.

Since the 1960s, the genetic code has been used to predict protein sequences from DNA and mRNA sequences. Our @nature.com article demonstrates that these predictions miss thousands of protein sequences present in human tissues. www.nature.com/articles/s41... 1/

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Nikolai Slavov@slavov-n.bsky.social · 2y ago

We report many proteins not predicted by the genetic code. They are stable & abundant O( 10³ ) copies / cell. Generative mechanisms include codon-anticodon mismatches & RNA modifications. Their abundance depends on codon frequency & protein stability. www.biorxiv.org/content/10.1...

Marten Chaillet@martenchaillet.bsky.social · 2mo ago

"With these capabilities in place, the question has shifted from 'what do we see?' to 'what have we learned?'." Fully agree, very insightful review from @nanigrotjahn.bsky.social

Danielle Grotjahn@nanigrotjahn.bsky.social · 2mo ago

Cryo-ET is often framed as a tool for in situ protein structure. But what if the real revolution is contextualization? I explore how #teamtomo is redefining what "local" means in organelle biology, revealing membrane states rather than just protein structures. tinyurl.com/localmembrane

Jo Judernatz@jojudernatz.bsky.social · 2mo ago

Glad to see the work of my PhD on the manchette microtubule now out in @embojournal.org: doi.org/10.1038/s443...

SPACA9 and MNMIP1 bridge the seam of spermatid manchette microtubules - The EMBO Journal

The manchette is a transient microtubule (MT)-based structure that is vital for the correct shaping of sperm during spermiogenesis. Throughout spermiogenesis, the manchette retains structural integrity for several days, raising the question of how its MTs are regulated. Here, using cryo-electron tomography of manchettes isolated from rat testes, we find that manchette MT ends are structurally diverse. We show that the MT-binding protein CLASP2 is present throughout the manchette and likely regulates both MT ends. Using cryo-electron microscopy single particle analysis and super-resolution microscopy, we reveal that SPACA9 and MNMIP1 (SH3D21) bind to the seam of manchette MTs from the luminal side. SPACA9 binds to both α- and β-tubulin of protofilament 1 but does not interact directly with protofilament 13, while MNMIP1 binds directly to protofilament 13. MNMIP1 further extends and threads through the MT lattice at the seam. Our study reveals a novel seam MT inner protein complex with a unique binding mode, providing a plausible explanation for MT regulation that maintains manchette integrity over an extended period.

doi.org

Reese Richardson@reeserichardson.bsky.social · 2mo ago

The Thermo Fisher situation keeps getting worse. We've now collected 450+ problematic images presented as verification data in TF's antibody catalog. This includes: 🖌️ Dozens more images with duplications or painting 🖨️ Hundreds of blots that all share the same background (behold slideshow below)