Back from beautiful and friendly Colombia ♥️ 🇨🇴

New study from our lab at NICHD, NIH! We identify TBC1D9 and TBC1D9B as novel ARL8 effectors that suppress exosome secretion by inactivating RAB11A and thus blocking exocyst-dependent fusion of multivesicular endosomes with the plasma membrane. www.pnas.org/doi/10.1073/...

By the way, @dshb-antibodies.bsky.social is a non-profit that sells quality antibodies to many proteins at exceptionally reasonable prices, without AI generated faux-validation images. Check them out. dshb.biology.uiowa.edu

Mark Peifer (He, him)@peiferlabunc.bsky.social · 2mo ago

Someone in the news departments of @nature.com or @science.org needs to take a look at this--its a huge scandal from the scientific supplier that has become a monopoly

In Gentle Light Kaoru Yamada

Awesome achievement! Sabastian Sawe of Kenya becomes first person to run a sub-2-hour marathon to win in London apnews.com/article/mara...

Sabastian Sawe of Kenya becomes first person to run a sub-2-hour marathon to win in London

Sabastian Sawe of Kenya has become the first person to break the fabled 2-hour barrier in the marathon in a huge moment in sports history.

apnews.com

Many thanks, @depaceraffa.bsky.social! I am deeply honored by this recognition and grateful to all who made it possible. 🙏

Raffaella De Pace@depaceraffa.bsky.social · 3mo ago

Congratulations to @juanbonifacino.bsky.social at the NIH on his election to the American Academy of Arts and Sciences — one of the nation's most prestigious honorary societies — in recognition of his distinguished contributions to cellular and developmental biology! 🎉 www.amacad.org/new-members-...

New work from Niccolo Mencacci @feinberg.northwestern.edu et al., with contribution from @depaceraffa.bsky.social in our lab at the NIH, identifies pathogenic variants in BORCS5, encoding a subunit of the BORC complex, as a cause of a severe neurodevelopmental disorder. www.jci.org/articles/vie...

#HappyMicroscopyMonday #microscopycommunity- Wayne S. Rasband Open Source Imaging Award recognizes individuals advancing open source imaging software or hardware by making tools freely accessible, modifiable, and impactful. Nominate or apply by May 1, 2026! buff.ly/5DYr7UO

One of the highlights of my recent trip to Argentine Patagonia: hiking to Emerald Lake in Tierra del Fuego. 🥾🏔️

#CapeCod #Poetry #Painting #Spring It is morning, and again I am the lucky person to be in it Mary Oliver 🎨 Kaoru Yamada

Sharing the announcement of this great conference @HHMIJanelia Cell Biology of Neurons and Circuits III www.janelia.org/you-janelia/...

Take a look at our Research Highlight: Adriana Golding et al. www.nature.com/articles/s41... We highlight the work by Ghoochani et al., who generated an atlas of brain lysosomal proteins and identified SLC45A1-associated disease as a lysosomal disorder: www.cell.com/cell/fulltex...

New from @depaceraffa.bsky.social from our lab #NICHD #NIH with Carlos Dominguez-Gonzalez, Adeline Vanderver @childrensphila.bsky.social et al.: pathogenic BLOC1S1 variants disrupt BLOC-1/BORC complexes in children with severe neurodevelopmental disorder authors.elsevier.com/c/1mqGAgeXHm-E

My picture for today's theme for #birdoftheday #powerpose is this female Kingfisher at Forest Farm NR. 24/02/26. 🪶 #birdingwales #ukbirding

Fluorescence Friday - DNA-PAINT imaging of axon initial segment TRIM46 ('cyan') and bIV spectrin ('red') by the incomparable Allison Melton in my laboratory. Just spectacular!

Two postdoc positions in way lab go live tomorrow......please pass the message along.......more details to follow.

Structure of the adaptor protein 4 (AP-4) complex revealed! AP-4 exists in a dynamic equilibrium between closed and open conformations in solution. ARF1 does not shift this equilibrium but is required—together with cargo—for membrane recruitment. rdcu.be/e1ozM

Highly recommend! Great mentor and environment.

Jeff Farrell@jeffreyafarrell.bsky.social · 6mo ago

I’m recruiting new members to the Farrell Lab this summer. We will have space for 1 postdoc (since Abhinav is leaving to start his own lab at U Arizona!!) and 2 postbacs, since my current two will leave for PhD programs at the end of the summer. More details in thread:

Our wonderful technician Xiaolin (Lin) Zhu is retiring after 27 years of dedicated service in our lab. We will miss her greatly, but we are happy for her as she begins this well-deserved new chapter in her life.

"It's my turn to use the microscope"

This year I had the chance to see Edvard Munch’s The Sick Child painting in Oslo. It’s a powerful reminder of what our Institute, NICHD, NIH, works to prevent and cure.

My lab in the NIH Intramural Program (Bethesda, MD) will be recruiting postdoctoral fellows over the next year with flexible start dates. We work on nanoscale cellular imaging of the plasma membrane and related organelles. Please reach out if you’re interested. www.training.nih.gov/jobs/pdp-053...

Latest preprint from our lab reports that the distinct pH of anterograde (less acidic) and retrograde (more acidic) lysosomal vesicles in the axon depends on assembly of the V1 and V0 domains of the vacuolar H+ ATPase, mediated by the metazoan RAVE complex www.biorxiv.org/content/10.6...

Interesting findings linking RAB14 to the EARP complex and the lipid transfer proteins SHIP164 and UHRF1BP1 on endosomes!

Jean lab@jeanlab-uds.bsky.social · 8mo ago

It is a nice way to end the week: our improved RAB GTPase BioID map now online! www.nature.com/articles/s42... We hope it will be useful to the community, and we're happy to share any reagents!

Painted tonight, but it’s nowhere near done, so instead here’s a piece I did in 2024 called Frosty Twilight (16”x20” mixed media). I went through a whole birches phase and this was part of that series. Anyhoooo….who’s ready for Monday?! I’m not! Lol #art #painting #mixedmedia #sundayscaries

This paper was a tour de force and would not be possible without he help of so many collaborators like @juanbonifacino.bsky.social and many more. Thank you!!!

Excited to announce the YAK lab's first paper and the discovery of the FIRST human cellular PRF signal to give access to two overlapping open reading frames (science.org/doi/10.1126/...)! Before we dive in, the story actually begins in a Nature from 11 years ago

Excited to share our latest manuscript by @saikat2025.bsky.social and an international team, reporting variants in the EARP- and GARP-interacting protein EIPR1 associated with a neurodevelopmental disorder. Will send you the PDF if you can’t access the article: academic.oup.com/brain/articl...

EIPR1 variants cause a neurodevelopmental disorder with endolysosomal and dense core vesicle defects

Abstract. EIPR1 (EARP-interacting protein 1, formerly known as TSSC1) is a WD40-domain protein that interacts with the EARP (endosome-associated recycling

academic.oup.com

Big thanks to Amelia Glazier and @jcellsci.bsky.social for including me in ‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science journals.biologists.com/jcs/article/... Happy to be in such great company!

‘First Persons’ through the decades – 100 years of notable scientists in Journal of Cell Science

Summary: JCS highlights the lives and careers of 10 notable scientists from around the world who published first author papers in our journal over the last 100 years.

journals.biologists.com

Thank you, @mishtudey.bsky.social and @cp-cellchembiol.bsky.social‬ for featuring this interview with @depaceraffa.bsky.social and Chad Williamson in connection to our article on BLOC-1 and BORC dlvr.it/TN9mpn

Cell Chemical Biology@cp-cellchembiol.bsky.social · 11mo ago

Meet the authors: Raffaella De Pace, Chad Williamson, and Juan Bonifacino http://dlvr.it/TN9cVw