Michael Way

@drmichaelway.bsky.social

Cell Biologist working at Crick Institute @crick.ac.uk - Cytoskeleton, Arp2/3 iso-complexes, Signalling and Vaccinia Virus. Editor-in chief Journal Cell Science - @jcellsci.bsky.social - comments are my own opinion

How do poxviruses initiate infection after getting into the cytoplasm? With Tom Calcraft, @miguel-virus-cells.bsky.social & Peter Rosenthal, @crick.ac.uk we solved the structure of the vaccinia virus portal that mediates viral assembly and early mRNA and subsequent genome release. rdcu.be/fwGTn

In situ structure of the poxvirus portal complex

Nature - Cryo-electron tomography uncovers the structure of a conserved hexameric ‘portal complex’ that spans the core wall in vaccinia virus, and shows how it is associated with viral...

rdcu.be

Scientists at the Crick have identified three crucial proteins that make up the ‘portal complex’ in the vaccinia poxvirus. The finding could lead to new ways of treating other poxviruses like mpox which have similar portal complexes. https://bit.ly/45vMhbi

Tuning into the channel helping poxviruses replicate

Uncovering the structure of the poxvirus ‘portal complex’, a channel used by the virus to release its genetic material into infected cells, could help develop new antiviral treatments.

bit.ly

🔬 Your tax dollars once paid a physicist whose own colleagues told him he was wasting the university's money. In 1951, Charles Townes sat on a D.C. park bench and worked out, on the back of an envelope, how to force molecules to release coherent radiation. 🧵 1/5

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