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@hp746.bsky.social

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@hp746.bsky.social · 14h ago

For CDI, fidaxomicin is preferred as first-line therapy for nonfulminant disease (oral vancomycin as acceptable alternative) www.cghjournal.org/article/S154... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

AGA Clinical Practice Update on Management of Clostridioides difficile Infection in Adults: Expert Review

Clostridioides difficile infection is a common cause of clinically significant diarrhea, often becomes recurrent, and can be fatal when severe or fulminant. The purpose of this America Gastroenterological Association (AGA) Clinical Practice Update Expert Review is to provide best practice advice for C difficile infection management.

cghjournal.org

@hp746.bsky.social · 2d ago

Purulent SSTIs produce pus because Staphylococcus aureus triggers an intense neutrophilic inflammatory response, leading to tissue destruction and abscess formation. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

A Structured Approach to Skin and Soft Tissue Infections (SSTIs) in an Ambulatory Setting

The skin is the largest, and arguably, the most vulnerable organ in the human body. Scratches and scrapes, bites and puncture wounds, impetigo and erysipelas—all these disruptions can lead to pain, sw...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · 3d ago

COSMOS study found that 12 weeks of simeprevir + sofosbuvir achieved high cure rates in patients with genotype 1 HCV pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Examining the clinical course of genotype 1 chronic hepatitis C patients treated with the cosmos regimen: including patients with advanced liver disease and East Asian ancestry

The COSMOS study was a phase 2a clinical trial that showed high cure rates of genotype 1 chronic hepatitis C (CHC) and a favorable side effect profile using a 12-week regimen of simeprevir + sofosbuvi...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · 7d ago

AGEP is most commonly drug-induced, particularly by systemic antibiotics such as beta-lactams, with a medianly rapid onset and frequent fever. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Drug Triggers and Clinic of Acute Generalized Exanthematous Pustulosis (AGEP): A Literature Case Series of 297 Patients

Acute generalized exanthematous pustulosis (AGEP) is a rare skin reaction, commonly caused by drugs. Available evidence mostly relies on small studies or case reports. We collected published AGEP case...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · last wk.

BLING III trial- continuous infusion of pip-tazo or meropenem did not significantly reduce 90-day mortality but improved clinical cure rates in critically ill patients with sepsis jamanetwork.com/journals/jam... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Continuous vs Intermittent β-Lactam Antibiotic Infusions in Critically Ill Patients With Sepsis

This clinical trial compares the efficacy of continuous vs intermittent infusion of a β-lactam antibiotic (piperacillin-tazobactam or meropenem) in decreasing all-cause mortality at 90 days in critica...

jamanetwork.com

@hp746.bsky.social · last wk.

PAT (such as liposomal ampho B, voriconazole, or caspofungin) reduced antifungal use and costs without increasing IFI-related mortality compared to empiric in AL patients. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Pre-emptive versus empirical antifungal therapy in patients with febrile neutropenia with acute leukaemia: a GIMEMA study

To compare the efficacy of pre-emptive antifungal therapy (PAT) and empirical antifungal therapy (EAT) in patients with febrile neutropenic acute leukaemia (AL) with/without anti-mold prophylaxis. We ...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · 2w ago

Serratia marcescens can acquire multiple resistance mechanisms, making accurate identification and infection-control measures particularly important in hospitalized patients journals.asm.org/doi/10.1128/... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Serratia Infections: from Military Experiments to Current Practice | Clinical Microbiology Reviews

SUMMARY Serratia species, in particular Serratia marcescens, are significant human pathogens. S. marcescens has a long and interesting taxonomic, medical experimentation, military experimentation, an...

journals.asm.org

@hp746.bsky.social · 2w ago

In a 20-patient case series, oral vancomycin 125 mg once daily for ≥8 weeks effectively prevented recurrent C. difficile in elderly patients with multiple relapses. link.springer.com/article/10.1... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Prolonged oral vancomycin for secondary prophylaxis of relapsing Clostridium difficile infection - BMC Infectious Diseases

Background Clostridium difficile infection (CDI) is an important cause of diarrhea and continues to be a major burden within healthcare institutions and in the community. For a small subset of patient...

link.springer.com

@hp746.bsky.social · 2w ago

The STROBE guidelines provide a 22-item checklist to improve the clarity, completeness, and critical appraisal of observational research. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

The STROBE guidelines

An observational study is a type of epidemiological study design, which can take the form of a cohort, a case–control, or a cross-sectional study. When presenting observational studies in manuscripts,...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · 2w ago

MAT2203 is an investigational oral amphotericin B formulation to reduce the nephrotoxicity and IV burden of conventional amphotericin B. This shows 5 compassionate-use patients cases. academic.oup.com/ofid/article... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Oral Lipid Nanocrystal Amphotericin B (MAT2203) for the Treatment of Invasive Fungal Infections

We report on 5 patients treated with MAT2203, an oral amphotericin-B formulation. MAT2203 was well tolerated and effectively treated deep tissue infections

academic.oup.com

@hp746.bsky.social · 3w ago

CROI 2024 phase I trial showed ultra-long-acting cabotegravir showed a longer half-life, better tolerability, and potential for every-4-month dosing compared with current cabotegravir. www.aidsmap.com/news/mar-202... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Ultra-long-acting cabotegravir could be taken three times a year for HIV PrEP and treatment

A longer-acting formulation of cabotegravir may offer an HIV pre-exposure prophylaxis (PrEP) and treatment option that could be administered once every four months, according to early study resul...

aidsmap.com

@hp746.bsky.social · 3w ago

NCC can mimic tumors on imaging. The patient was initially misdiagnosed with meningioma but had NCC. Treatment with albendazole, prednisolone, and phenytoin led to full recovery. www.cureus.com/articles/461... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Neurocysticercosis: An Easy to Miss Diagnosis in Non-Endemic Regions

A 29-year-old male presented with swollen gums and stomatitis for the past two months. History revealed that he had moved to the United States from India six years ago and had a first episode of gener...

cureus.com

@hp746.bsky.social · 3w ago

Daptomycin-induced DRESS syndrome and eosinophilic pneumonia can mimic conditions such as viral pneumonitis. Promptly d/c daptomycin and give high-dose corticosteroids when indicated. www.cureus.com/articles/335... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19

Adverse drug reactions are critical considerations in managing complex medical conditions. Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but potentially life-threate...

cureus.com

@hp746.bsky.social · 3w ago

16S rRNA sequencing identifies bacterial DNA. Its long turnaround time limits clinical use. May be useful for culture-negative infections or pathogens that are difficult to culture. journals.asm.org/doi/10.1128/... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Diagnostic Yield and Impact on Antimicrobial Management of 16S rRNA Testing of Clinical Specimens | Microbiology Spectrum

16S rRNA gene sequencing has been increasingly used in clinical practice. Using the final diagnosis as a gold standard, the sensitivity of 16S rRNA gene sequencing was fair. In the setting with no 16S...

journals.asm.org

@hp746.bsky.social · 3w ago

CAP overdiagnosis was common among older adults and those presenting with dementia or AMS. Unnecessary full-course antibiotics expose these patients to more ADE (risk >>> benefits) jamanetwork.com/journals/jam... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Inappropriate Diagnosis of Pneumonia Among Hospitalized Adults

This cohort study characterizes inappropriate diagnosis of community-acquired pneumonia among hospitalized patients in 48 Michigan hospitals.

jamanetwork.com

@hp746.bsky.social · 4w ago

bNAbs target conserved HIV regions but are limited by resistance and delivery challenges. Gene-based and combination therapies may improve their potential. link.springer.com/article/10.1... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Future of bNAbs in HIV Treatment - Current HIV/AIDS Reports

Purpose of Review Broadly neutralizing antibodies (bNAbs) represent a novel approach to HIV treatment, prevention, and cure strategies. As research advances, the clinical application of bNAbs continue...

link.springer.com

@hp746.bsky.social · 4w ago

ESR has decent accuracy for diagnosing DFO and may be useful as an initial screening tool, but it should not be used alone to confirm or rule out osteomyelitis. www.frontiersin.org/journals/end... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Frontiers | Diagnostic value and integrated threshold of ESR for diabetic foot osteomyelitis: a systemic review and meta-analysis

BackgroundDiabetic foot osteomyelitis (DFO) is a severe complication of diabetic foot infections (DFI). Early and accurate diagnosis is crucial for improving...

frontiersin.org

@hp746.bsky.social · last mo.

Pivmecillinam has been used in EU for 40+ years but was only recently FDA-approved in 2024. Reanalyzed 14 EU trial data using current FDA criteria, supporting its efficacy. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Pivmecillinam for Treatment of Uncomplicated Urinary Tract Infection: New Efficacy Analysis

In April 2024—over 40 years after its first approval in Europe—pivmecillinam received approval from the United States Food and Drug Administration (FDA) for the treatment of uncomplicated urinary trac...

pmc.ncbi.nlm.nih.gov

@hp746.bsky.social · last mo.

Weak inducer/good substrate drugs seem promising, but the hidden AmpD mutants survive and expand, masking the true clinical picture until resistance emerges. pmc.ncbi.nlm.nih.gov/articles/PMC... #OTILT @bwdionne.bsky.social @jeffpears0n.bsky.social @dannawang.bsky.social

Beyond Susceptible and Resistant, Part I: Treatment of Infections Due to Gram-Negative Organisms With Inducible β-Lactamases

Inactivation of β-lactams by the action of β-lactamase enzymes is the most common mode of resistance to these drugs among Gram-negative organisms. The genomes of some key clinical pathogens such as En...

pmc.ncbi.nlm.nih.gov