Preprint alert! 🚨 We are very excited to share our new manuscript on Bohring-Opitz syndrome, a devastating rare monogenic disorder driven by truncating variants in ASXL1. This project was led by PhD student Emma Doyle, one of the OG Conway lab members 💪. 1/6 www.biorxiv.org/content/10.6...

Divergent Pathogenic PR-DUB Complex Variants Converge Functionally Via PRC2 Displacement From Chromatin

The PR-DUB complex is responsible for erasing the repressive histone modification, H2AK119ub1. ASXL1-3 proteins are mutually exclusive catalytic partners of BAP1 in the PR-DUB complex. Somatic heteroz...

biorxiv.org

Second annual Conway/ Coughlan lab pumpkin carving competition this morning with plenty of coffee and treats to keep us going! Skills getting better every year. Can anyone spot the nucleosomes? @coughlan-lab.bsky.social @ucddublin.bsky.social @ucd-sbbs.bsky.social

Our very own Evan Matthews, from @coughlan-lab.bsky.social, will be running the Dublin Marathon this month in aid of the Irish Cancer Society! If you want to show Evan and the ICS your support you can donate through the link below! eventmaster.ie/fundraising/... @ucddublin.bsky.social 🏃💨

🚨🚨 New PhD position available in my research group @ucddublin.bsky.social ! If you are interested in enhancer biology, functional genomics and cancer get in touch! Position starts Sep 2025. More details at the link below. www.coughlan-lab.com/team Please share with anyone who may interested!

2-year computational postdoc position available to join our growing team to work on super-enhancers & transcription factors in AML @ucddublin.bsky.social. This project will use patient biopsies to identify 'epigenomic' sensitivities for this devastating cancer. conwaychromatinlab.com/team

Team — Conway Lab

conwaychromatinlab.com

Celebrating a lot of lab milestones this year and the first Conway/Coughlan lab joint Christmas party 🎄🎅 @coughlan-lab.bsky.social

How does PRC1 counteract transcription? See this preview from @adrianbracken.bsky.social and I on an exciting new study from @robklose.bsky.social lab where they show ncPRC1 blocks the early stages of transcription. www.sciencedirect.com/science/arti... @conwayer1.bsky.social for title inspo!